--- title: "Cardarine (GW501516): Dosing & Vendor Prices" description: "Cardarine (GW501516): dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Cardarine (GW501516)" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Cardarine (GW501516)", "description": "Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome. It is not a SARM and has nothing to do with androgen receptors, despite being sold alongside them. Company trials reached phase 2 and the program ended there. GW501516 has never been approved by any regulator. PPAR-delta is a transcription factor found in muscle, fat and liver that controls the genes for burning fat. Turning it on shifts cells toward using fatty acids for fuel instead of carbohydrate. In human skeletal muscle cells, GW501516 increased fat oxidation and raised expression of CPT1, CD36 and ABCA1 (PMID: 17110604). The endurance reputation is built on rodent work. In mice, a PPAR-delta agonist combined with exercise training increased oxidative muscle fibers and running endurance beyond training alone, and the same paper coined the phrase exercise mimetic (PMID: 18674809). Mice treated with GW501516 also showed improved muscle function in a muscular dystrophy model (PMID: 22908954). No human trial has ever measured endurance, VO2max or time to exhaustion on this drug. What the human trials did measure was blood lipids. In healthy volunteers dosed for two weeks, HDL cholesterol rose in both treatment groups while it fell on placebo, and clearance of fat after a meal improved (PMID: 17110604). In 268 people with low HDL, twelve weeks of treatment raised HDL by up to 16.9 percent and lowered triglycerides by 16.9 percent, apolipoprotein B by 14.9 percent and LDL cholesterol by 7.3 percent (PMID: 22814748). Two weeks in moderately overweight men lowered triglycerides by 30 percent and liver fat by 20 percent (PMID: 18024853), and a crossover study in dyslipidemic men with central obesity mapped the lipoprotein kinetics behind those changes (PMID: 21816786). The cancer question is the reason this compound is not on pharmacy shelves. In Apc(min) mice, which are prone to intestinal polyps, GW501516 significantly increased both the number and the size of polyps, with a fivefold rise in polyps larger than 2 mm (PMID: 14758356). A later mouse study found that the same agonist accelerated colorectal tumorigenesis while a PPAR-delta antagonist suppressed it (PMID: 30679176). Reviewing that work, researchers warned in print that PPAR-delta agonists then in development for dyslipidemia and obesity might raise tumor risk in humans (PMID: 15539957). GW1516 was added to the WADA prohibited list in January 2009 and its urinary metabolites were characterized for routine doping control (PMID: 19946680). When 44 internet products sold as SARMs were analyzed, GW501516 was among the unapproved drugs found in products that did not declare it (PMID: 29183075).", "url": "https://www.bodyhackguide.co/compound/cardarine", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "84.99", "highPrice": "84.99", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "84.99", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://disguisedalpha.com/product/cardarine/?coupon=reddit", "seller": { "@type": "Organization", "name": "Disguised Alpha", "url": "https://disguisedalpha.com/?coupon=reddit" }, "name": "Cardarine (GW501516) 500mg liquid" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Cardarine (GW501516)", "description": "Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome. It is not a SARM and has nothing to do with androgen receptors, despite being sold alongside them. Company trials reached phase 2 and the program ended there. GW501516 has never been approved by any regulator. PPAR-delta is a transcription factor found in muscle, fat and liver that controls the genes for burning fat. Turning it on shifts cells toward using fatty acids for fuel instead of carbohydrate. In human skeletal muscle cells, GW501516 increased fat oxidation and raised expression of CPT1, CD36 and ABCA1 (PMID: 17110604). The endurance reputation is built on rodent work. In mice, a PPAR-delta agonist combined with exercise training increased oxidative muscle fibers and running endurance beyond training alone, and the same paper coined the phrase exercise mimetic (PMID: 18674809). Mice treated with GW501516 also showed improved muscle function in a muscular dystrophy model (PMID: 22908954). No human trial has ever measured endurance, VO2max or time to exhaustion on this drug. What the human trials did measure was blood lipids. In healthy volunteers dosed for two weeks, HDL cholesterol rose in both treatment groups while it fell on placebo, and clearance of fat after a meal improved (PMID: 17110604). In 268 people with low HDL, twelve weeks of treatment raised HDL by up to 16.9 percent and lowered triglycerides by 16.9 percent, apolipoprotein B by 14.9 percent and LDL cholesterol by 7.3 percent (PMID: 22814748). Two weeks in moderately overweight men lowered triglycerides by 30 percent and liver fat by 20 percent (PMID: 18024853), and a crossover study in dyslipidemic men with central obesity mapped the lipoprotein kinetics behind those changes (PMID: 21816786). The cancer question is the reason this compound is not on pharmacy shelves. In Apc(min) mice, which are prone to intestinal polyps, GW501516 significantly increased both the number and the size of polyps, with a fivefold rise in polyps larger than 2 mm (PMID: 14758356). A later mouse study found that the same agonist accelerated colorectal tumorigenesis while a PPAR-delta antagonist suppressed it (PMID: 30679176). Reviewing that work, researchers warned in print that PPAR-delta agonists then in development for dyslipidemia and obesity might raise tumor risk in humans (PMID: 15539957). GW1516 was added to the WADA prohibited list in January 2009 and its urinary metabolites were characterized for routine doping control (PMID: 19946680). When 44 internet products sold as SARMs were analyzed, GW501516 was among the unapproved drugs found in products that did not declare it (PMID: 29183075).", "lastReviewed": "2026-09-07T04:48:28.402Z", "url": "https://www.bodyhackguide.co/compound/cardarine", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Cardarine (GW501516)", "alternateName": [ "GW501516", "GW-501516", "GW1516", "GSK-516", "Endurobol", "Cardarin" ], "description": "Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome. It is not a SARM and has nothing to do with androgen receptors, despite being sold alongside them. Company trials reached phase 2 and the program ended there. GW501516 has never been approved by any regulator. PPAR-delta is a transcription factor found in muscle, fat and liver that controls the genes for burning fat. Turning it on shifts cells toward using fatty acids for fuel instead of carbohydrate. In human skeletal muscle cells, GW501516 increased fat oxidation and raised expression of CPT1, CD36 and ABCA1 (PMID: 17110604). The endurance reputation is built on rodent work. In mice, a PPAR-delta agonist combined with exercise training increased oxidative muscle fibers and running endurance beyond training alone, and the same paper coined the phrase exercise mimetic (PMID: 18674809). Mice treated with GW501516 also showed improved muscle function in a muscular dystrophy model (PMID: 22908954). No human trial has ever measured endurance, VO2max or time to exhaustion on this drug. What the human trials did measure was blood lipids. In healthy volunteers dosed for two weeks, HDL cholesterol rose in both treatment groups while it fell on placebo, and clearance of fat after a meal improved (PMID: 17110604). In 268 people with low HDL, twelve weeks of treatment raised HDL by up to 16.9 percent and lowered triglycerides by 16.9 percent, apolipoprotein B by 14.9 percent and LDL cholesterol by 7.3 percent (PMID: 22814748). Two weeks in moderately overweight men lowered triglycerides by 30 percent and liver fat by 20 percent (PMID: 18024853), and a crossover study in dyslipidemic men with central obesity mapped the lipoprotein kinetics behind those changes (PMID: 21816786). The cancer question is the reason this compound is not on pharmacy shelves. In Apc(min) mice, which are prone to intestinal polyps, GW501516 significantly increased both the number and the size of polyps, with a fivefold rise in polyps larger than 2 mm (PMID: 14758356). A later mouse study found that the same agonist accelerated colorectal tumorigenesis while a PPAR-delta antagonist suppressed it (PMID: 30679176). Reviewing that work, researchers warned in print that PPAR-delta agonists then in development for dyslipidemia and obesity might raise tumor risk in humans (PMID: 15539957). GW1516 was added to the WADA prohibited list in January 2009 and its urinary metabolites were characterized for routine doping control (PMID: 19946680). When 44 internet products sold as SARMs were analyzed, GW501516 was among the unapproved drugs found in products that did not declare it (PMID: 29183075).", "activeIngredient": "Cardarine (GW501516)", "administrationRoute": "Oral", "mechanismOfAction": "GW501516 is a selective agonist of peroxisome proliferator-activated receptor delta (PPAR-delta, also written PPAR-beta/delta), a ligand-activated transcription factor expressed strongly in skeletal muscle, heart, adipose tissue and macrophages. Binding activates transcription of genes controlling fatty acid uptake and oxidation. In cultured human skeletal muscle cells the compound increased fatty acid oxidation and raised carnitine palmitoyltransferase 1, CD36 and ABCA1 expression, the last of which links the drug to HDL particle lipidation and helps explain the HDL rise seen in volunteers (PMID: 17110604). In men with central obesity, the lipid changes were driven by faster catabolism of VLDL particles and lower apolipoprotein C-III production (PMID: 21816786). PPAR-delta activation also promotes cell proliferation in intestinal tissue, which is the basis of the tumor concern (PMID: 14758356).", "dosageForm": "liquid", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Cardarine (GW501516) used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome. It is not a SARM and has nothing to do with androgen receptors, despite being sold alongside them. Company trials reached phase 2 and the program ended there. GW501516 has never been approved by any regulator. PPAR-delta is a transcription factor found in muscle, fat and liver that controls the genes for burning fat. Turning it on shifts cells toward using fatty acids for fuel instead of carbohydrate. In human skeletal muscle cells, GW501516 increased fat oxidation and raised expression of CPT1, CD36 and ABCA1 (PMID: 17110604). The endurance reputation is built on rodent work. In mice, a PPAR-delta agonist combined with exercise training increased oxidative muscle fibers and running endurance beyond training alone, and the same paper coined the phrase exercise mimetic (PMID: 18674809). Mice treated with GW501516 also showed improved muscle function in a muscular dystrophy model (PMID: 22908954). No human trial has ever measured endurance, VO2max or time to exhaustion on this drug. What the human trials did measure was blood lipids. In healthy volunteers dosed for two weeks, HDL cholesterol rose in both treatment groups while it fell on placebo, and clearance of fat after a meal improved (PMID: 17110604). In 268 people with low HDL, twelve weeks of treatment raised HDL by up to 16.9 percent and lowered triglycerides by 16.9 percent, apolipoprotein B by 14.9 percent and LDL cholesterol by 7.3 percent (PMID: 22814748). Two weeks in moderately overweight men lowered triglycerides by 30 percent and liver fat by 20 percent (PMID: 18024853), and a crossover study in dyslipidemic men with central obesity mapped the lipoprotein kinetics behind those changes (PMID: 21816786). The cancer question is the reason this compound is not on pharmacy shelves. In Apc(min) mice, which are prone to intestinal polyps, GW501516 significantly increased both the number and the size of polyps, with a fivefold rise in polyps larger than 2 mm (PMID: 14758356). A later mouse study found that the same agonist accelerated colorectal tumorigenesis while a PPAR-delta antagonist suppressed it (PMID: 30679176). Reviewing that work, researchers warned in print that PPAR-delta agonists then in development for dyslipidemia and obesity might raise tumor risk in humans (PMID: 15539957). GW1516 was added to the WADA prohibited list in January 2009 and its urinary metabolites were characterized for routine doping control (PMID: 19946680). When 44 internet products sold as SARMs were analyzed, GW501516 was among the unapproved drugs found in products that did not declare it (PMID: 29183075)." } }, { "@type": "Question", "name": "What forms does Cardarine (GW501516) come in?", "acceptedAnswer": { "@type": "Answer", "text": "Cardarine (GW501516) is available in liquid form." } }, { "@type": "Question", "name": "How much does Cardarine (GW501516) cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $84.99 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare Cardarine (GW501516) vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. 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Cardarine (GW501516) ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Best price right now $0.17/mg · $84.99 for 500mg at Disguised Alpha [Buy at Disguised Alpha](https://www.bodyhackguide.co/go/disguised-alpha?utm_source=compound-sticky-bar&utm_campaign=3ae8d52b-2bc1-4048-9ce2-73a8e3a20c55&utm_medium=best-price-cta) [Where to buy Cardarine (GW501516)](/buy/cardarine) [Cardarine (GW501516) coupon codes](/coupons/cardarine) [Cardarine (GW501516) protocol](/protocol/cardarine) [Alternatives to Cardarine (GW501516)](/alternatives-to/cardarine) [Cardarine (GW501516) side effects](/side-effects/cardarine) 1. [Home](/) 3. [Compounds](/compare) 5. Cardarine (GW501516) ![Cardarine (GW501516) molecular structure](/assets/peptide-structure-placeholder-DUmZBF_j.png) # Cardarine (GW501516) Metabolic Discontinued Download PDF Also known as: GW501516, GW-501516, GW1516, GSK-516, Endurobol, Cardarin Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome. It is not a SARM and has nothing to do with androgen receptors, despite being sold alongside them. Half-Life: Not reported in the published human trials; the phase 1 and phase 2 studies described lipid outcomes over two to twelve weeks of oral dosing without publishing a terminal half-life (PMID: 17110604; PMID: 22814748) Route: Oral MW: 453.51 g/mol CAS: 317318-70-0 Last reviewed: Sep 7, 2026 [ Metabolic Category ](/wiki#cat-metabolic) Discontinued Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $84.99 10 mL (50 mg/mL) · liquid [Buy Now](https://disguisedalpha.com/product/cardarine/?coupon=reddit) Compare 1 vendor ### At A Glance Mechanism GW501516 is a selective agonist of peroxisome proliferator-activated receptor delta (PPAR-delta, also written PPAR-beta/delta), a ligand-activated transcription factor expressed strongly in skeletal muscle, heart, adipose tissue and macrophages. Binding activates transcription of… Half-Life Not reported in the published human trials; the phase 1 and phase 2 studies described lipid outcomes over two to twelve weeks of oral dosing without publishing a terminal half-life (PMID: 17110604; PMID: 22814748) Routes Oral Potential Benefits Raised HDL cholesterol by up to 16.9 percent and lowered triglycerides by 16.9 percent over twelve weeks in 268 adults with low HDL cholesterol (PMID: 22814748) Lowered fasting triglycerides by 30 percent and liver fat content by 20 percent over two weeks in moderately overweight men (PMID: 18024853) Increased HDL cholesterol and improved post-meal fat clearance over two weeks in healthy sedentary volunteers (PMID: 17110604) Increased oxidative muscle fibers and treadmill running endurance when combined with training in mice (PMID: 18674809) Increased fatty acid oxidation and CPT1, CD36 and ABCA1 expression in cultured human skeletal muscle cells (PMID: 17110604) ### Overview Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome. It is not a SARM and has nothing to do with androgen receptors, despite being sold alongside them. Company trials reached phase 2 and the program ended there. GW501516 has never been approved by any regulator. PPAR-delta is a transcription factor found in muscle, fat and liver that controls the genes for burning fat. Turning it on shifts cells toward using fatty acids for fuel instead of carbohydrate. In human skeletal muscle cells, GW501516 increased fat oxidation and raised expression of CPT1, CD36 and ABCA1 (PMID: 17110604). The endurance reputation is built on rodent work. In mice, a PPAR-delta agonist combined with exercise training increased oxidative muscle fibers and running endurance beyond training alone, and the same paper coined the phrase exercise mimetic (PMID: 18674809). Mice treated with GW501516 also showed improved muscle function in a muscular dystrophy model (PMID: 22908954). No human trial has ever measured endurance, VO2max or time to exhaustion on this drug. What the human trials did measure was blood lipids. In healthy volunteers dosed for two weeks, HDL cholesterol rose in both treatment groups while it fell on placebo, and clearance of fat after a meal improved (PMID: 17110604). In 268 people with low HDL, twelve weeks of treatment raised HDL by up to 16.9 percent and lowered triglycerides by 16.9 percent, apolipoprotein B by 14.9 percent and LDL cholesterol by 7.3 percent (PMID: 22814748). Two weeks in moderately overweight men lowered triglycerides by 30 percent and liver fat by 20 percent (PMID: 18024853), and a crossover study in dyslipidemic men with central obesity mapped the lipoprotein kinetics behind those changes (PMID: 21816786). The cancer question is the reason this compound is not on pharmacy shelves. In Apc(min) mice, which are prone to intestinal polyps, GW501516 significantly increased both the number and the size of polyps, with a fivefold rise in polyps larger than 2 mm (PMID: 14758356). A later mouse study found that the same agonist accelerated colorectal tumorigenesis while a PPAR-delta antagonist suppressed it (PMID: 30679176). Reviewing that work, researchers warned in print that PPAR-delta agonists then in development for dyslipidemia and obesity might raise tumor risk in humans (PMID: 15539957). GW1516 was added to the WADA prohibited list in January 2009 and its urinary metabolites were characterized for routine doping control (PMID: 19946680). When 44 internet products sold as SARMs were analyzed, GW501516 was among the unapproved drugs found in products that did not declare it (PMID: 29183075). ### Potential Research Fields PPAR-delta signaling Lipid metabolism Exercise mimetics Sports drug testing ## Chemical Information IUPAC Name Not yet available CAS Number 317318-70-0 Molecular Formula C21H18F3NO3S2 Molecular Mass 453.51 g/mol ![Cardarine (GW501516) molecular structure](https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/9803963/PNG) [View on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/9803963) ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions ### Contraindications Mechanism-based and animal-data-based: the demonstrated promotion of intestinal tumor growth in mice argues against use by anyone with a personal or family history of colorectal polyps, colorectal cancer or Lynch-type syndromes (PMID: 14758356; PMID: 30679176). No human pregnancy, lactation, pediatric, hepatic or renal impairment data exist. Prohibited at all times in tested sport under WADA section S4.4 (PMID: 19946680). Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $84.99 Best $/mg $0.1700 Vendors 1 Listings 1 liquid [Sign in for alerts ](/auth) Form Allliquid Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) [Disguised Alpha](/vendor/disguised-alpha) [50 ](/vendor-trust-scorecard) 🇺🇸 US 🇪🇺 EU 🇬🇧 UK Cardarine (GW501516) 50 mg/mL, 10 mL liquid 10 mL (50 mg/mL) ● In Stock $84.99 BEST $0.170 — [Buy](https://disguisedalpha.com/product/cardarine/?coupon=reddit) Get Cardarine (GW501516) Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $84.99 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Cardarine (GW501516). [Sign in](/auth) Current low $84.99 as of Sep 7, 2026 7-day low $84.99 30-day low $84.99 30-day change — baseline building Tracking since Sep 7, 2026 · 1 data point ### Vendors Selling Cardarine (GW501516) [ ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) #### Disguised Alpha 1 listing · from $84.99 ](/vendor/disguised-alpha) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### AICAR (acadesine) Metabolic Phase 3 AICAR is a nucleoside analog of adenosine. t½ Intact acadesine was measurable in plasma for only about 2 hours after a short intravenous infusion in four healthy men, with total plasma clearance of 2.2 L/h/kg and negligible protein binding; radiolabeled drug-derived material had an apparent terminal half-life of about one week, reflecting metabolites rather than parent compound (PMID: 8227467) Preclinical View Profile ](/compound/aicar)[ ### Amlexanox Metabolic FDA Approved Amlexanox is an old anti-inflammatory drug with a second life. t½ Not established in published human pharmacokinetic studies for the oral capsule form; a validated plasma assay has been used for preclinical pharmacokinetics in rats (PMID: 34842293) Preclinical View Profile ](/compound/amlexanox)[ ### Berberine Metabolic Preclinical Berberine is an isoquinoline alkaloid — a naturally occurring plant secondary metabolite with a characteristic yellow color — extracted from the roots, rhizomes, stems, and bark of several plant genera including Berberis (barberry, Oregon grape), Coptis (goldthread), Hydrastis (goldenseal), Phellodendron (Amur cork tree), and Tinospora (guduchi). Preclinical View Profile ](/compound/berberine)[ ### Metformin Metabolic Preclinical Metformin is a biguanide-class oral antihyperglycemic medication that has been in continuous clinical use since 1957 (in France under the brand name Glucophage) and is now the most-prescribed diabetes medication worldwide with over 150 million prescriptions annually. Preclinical View Profile ](/compound/metformin)[ ### SLU-PP-915 Metabolic Preclinical SLU-PP-915 is an experimental agonist of the estrogen-related receptors, a family of three orphan nuclear receptors called ERR-alpha, ERR-beta and ERR-gamma that control genes for mitochondrial biogenesis, oxidative phosphorylation, fatty acid oxidation and the Krebs cycle. t½ Not established in humans; in mice it is orally bioavailable and active by both oral and intraperitoneal routes, unlike its predecessor SLU-PP-332 (PMID: 41421047) Preclinical View Profile ](/compound/slu-pp-915)[ ### Sobetirome (GC-1) Metabolic Discontinued Sobetirome, also called GC-1 and later QRX-431, is a synthetic analog of thyroid hormone made in Thomas Scanlan laboratory and first described in 1998 as a high-affinity, subtype-selective agonist for the thyroid hormone receptor (PMID: 9653548). t½ Not established in humans; no peer-reviewed human pharmacokinetic study has been published, and the phase 1 program results were not reported in the peer-reviewed literature (PMID: 19002578) Preclinical View Profile ](/compound/sobetirome) [ View Full Dosage Guide → Protocols, calculator & safety for Cardarine (GW501516) ](/guides/dosage/cardarine) ### Best Price ![Disguised Alpha logo](https://disguisedalpha.com/wp-content/themes/assets/logos/disguised-logo-2x.png) Disguised Alpha $84.99 [Buy Now](https://disguisedalpha.com/product/cardarine/?coupon=reddit) 1 vendors · 1 listings ### Research Score 30 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Not reported in the published human trials; the phase 1 and phase 2 studies described lipid outcomes over two to twelve weeks of oral dosing without publishing a terminal half-life (PMID: 17110604; PMID: 22814748) Molecular Weight 453.51 g/mol Administration Oral CAS Number 317318-70-0 Trial Phase Discontinued 0 [Full Dosage Guide](/guides/dosage/cardarine)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Cardarine (GW501516) used for in research? Cardarine is the market name for GW501516, a synthetic agonist of the nuclear receptor PPAR-delta developed by GlaxoSmithKline as a treatment for low HDL cholesterol and the lipid problems that travel with metabolic syndrome. It is not a SARM and has nothing to do with androgen receptors, despite being sold alongside them. Company trials reached phase 2 and the program ended there. GW501516 has never been approved by any regulator. PPAR-delta is a transcription factor found in muscle, fat and liver that controls the genes for burning fat. Turning it on shifts cells toward using fatty acids for fuel instead of carbohydrate. In human skeletal muscle cells, GW501516 increased fat oxidation and raised expression of CPT1, CD36 and ABCA1 (PMID: 17110604). The endurance reputation is built on rodent work. In mice, a PPAR-delta agonist combined with exercise training increased oxidative muscle fibers and running endurance beyond training alone, and the same paper coined the phrase exercise mimetic (PMID: 18674809). Mice treated with GW501516 also showed improved muscle function in a muscular dystrophy model (PMID: 22908954). No human trial has ever measured endurance, VO2max or time to exhaustion on this drug. What the human trials did measure was blood lipids. In healthy volunteers dosed for two weeks, HDL cholesterol rose in both treatment groups while it fell on placebo, and clearance of fat after a meal improved (PMID: 17110604). In 268 people with low HDL, twelve weeks of treatment raised HDL by up to 16.9 percent and lowered triglycerides by 16.9 percent, apolipoprotein B by 14.9 percent and LDL cholesterol by 7.3 percent (PMID: 22814748). Two weeks in moderately overweight men lowered triglycerides by 30 percent and liver fat by 20 percent (PMID: 18024853), and a crossover study in dyslipidemic men with central obesity mapped the lipoprotein kinetics behind those changes (PMID: 21816786). The cancer question is the reason this compound is not on pharmacy shelves. In Apc(min) mice, which are prone to intestinal polyps, GW501516 significantly increased both the number and the size of polyps, with a fivefold rise in polyps larger than 2 mm (PMID: 14758356). A later mouse study found that the same agonist accelerated colorectal tumorigenesis while a PPAR-delta antagonist suppressed it (PMID: 30679176). Reviewing that work, researchers warned in print that PPAR-delta agonists then in development for dyslipidemia and obesity might raise tumor risk in humans (PMID: 15539957). GW1516 was added to the WADA prohibited list in January 2009 and its urinary metabolites were characterized for routine doping control (PMID: 19946680). When 44 internet products sold as SARMs were analyzed, GW501516 was among the unapproved drugs found in products that did not declare it (PMID: 29183075). What forms does Cardarine (GW501516) come in? Cardarine (GW501516) is available in liquid form. How much does Cardarine (GW501516) cost? Prices start at $84.99 across 1 verified vendor. How do I compare Cardarine (GW501516) vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### AICAR (acadesine) Metabolic Phase 3 AICAR is a nucleoside analog of adenosine. t½ Intact acadesine was measurable in plasma for only about 2 hours after a short intravenous infusion in four healthy men, with total plasma clearance of 2.2 L/h/kg and negligible protein binding; radiolabeled drug-derived material had an apparent terminal half-life of about one week, reflecting metabolites rather than parent compound (PMID: 8227467) Preclinical View Profile ](/compound/aicar)[ ### Amlexanox Metabolic FDA Approved Amlexanox is an old anti-inflammatory drug with a second life. t½ Not established in published human pharmacokinetic studies for the oral capsule form; a validated plasma assay has been used for preclinical pharmacokinetics in rats (PMID: 34842293) Preclinical View Profile ](/compound/amlexanox)[ ### Berberine Metabolic Preclinical Berberine is an isoquinoline alkaloid — a naturally occurring plant secondary metabolite with a characteristic yellow color — extracted from the roots, rhizomes, stems, and bark of several plant genera including Berberis (barberry, Oregon grape), Coptis (goldthread), Hydrastis (goldenseal), Phellodendron (Amur cork tree), and Tinospora (guduchi). Preclinical View Profile ](/compound/berberine)[ ### Metformin Metabolic Preclinical Metformin is a biguanide-class oral antihyperglycemic medication that has been in continuous clinical use since 1957 (in France under the brand name Glucophage) and is now the most-prescribed diabetes medication worldwide with over 150 million prescriptions annually. Preclinical View Profile ](/compound/metformin)[ ### SLU-PP-915 Metabolic Preclinical SLU-PP-915 is an experimental agonist of the estrogen-related receptors, a family of three orphan nuclear receptors called ERR-alpha, ERR-beta and ERR-gamma that control genes for mitochondrial biogenesis, oxidative phosphorylation, fatty acid oxidation and the Krebs cycle. t½ Not established in humans; in mice it is orally bioavailable and active by both oral and intraperitoneal routes, unlike its predecessor SLU-PP-332 (PMID: 41421047) Preclinical View Profile ](/compound/slu-pp-915)[ ### Sobetirome (GC-1) Metabolic Discontinued Sobetirome, also called GC-1 and later QRX-431, is a synthetic analog of thyroid hormone made in Thomas Scanlan laboratory and first described in 1998 as a high-affinity, subtype-selective agonist for the thyroid hormone receptor (PMID: 9653548). t½ Not established in humans; no peer-reviewed human pharmacokinetic study has been published, and the phase 1 program results were not reported in the peer-reviewed literature (PMID: 19002578) Preclinical View Profile ](/compound/sobetirome) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-cardarine) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews. 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