--- title: "BPC-157: Dosing & Vendor Prices | BodyHackGuide" url: https://www.bodyhackguide.co/compound/bpc-157 description: "BPC-157: dosing protocols, mechanism & side effects, 214 PubMed results. Compare 7 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Image: BPC-157 molecular structure (https://www.bodyhackguide.co/assets/peptide-structure-placeholder-DUmZBF_j.png) # BPC-157 Injury, Repair & Recovery (https://www.bodyhackguide.co/wiki#cat-injury,-repair-&-recovery)Preclinical Also known as: BPC, BPC-157 Capsules, BPC-157 500mcg Capsules, Pentadecapeptide, Repair Balm, Oral BPC-157, BPC-157 Oral, Body Protection Compound BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a partial sequence of human gastric juice protein BPC. It has a molecular weight of 1419.53 Da and a CAS number of 137525-51-0. R Featured vendor $2.67/mg $79.99 for 30mg at ResearchChemHQ Β· Buy at RC: https://researchchemhq.co/product/bpc-157-caps/?ref=oyxnywoz Half-life: Short plasma half-life Route: Subcutaneous, Oral, Intraperitoneal, Intravenous MW: 1419.5 g/mol (average) CAS: 137525-51-0 214 PubMed results (https://pubmed.ncbi.nlm.nih.gov/?term=BPC-157) Last reviewed: May 4, 2026 Reconstitution Calculator for BPC-157 Pre-filled Β· 5mg vial Β· 250mcg dose https://www.bodyhackguide.co/tools/reconstitution/bpc-157 ## Overview ### At A Glance Mechanism Nitric Oxide (NO) System Modulation… Half-Life Short plasma half-life. The first formal preclinical ADME study reported an elimination half-life under ~30 minutes after IV/IM dosing in rats and dogs, with linear dose-proportional kinetics (PMID: 36588717); a 2026 biopharmaceutical review confirms this sub-30-minute plasma half-life and highlights a pharmacokinetic-pharmacodynamic disconnect, as biological effects persist for hours to days (PMID: 42198317). No full human pharmacokinetic study has been published; twice-daily dosing is empirical/community-standard rather than PK-derived. Dosing Twice daily (AM and PM) for optimal serum levels; once daily acceptable Dose Range 200-500 mcg subcutaneous 1-2x daily (community protocols); 1-10 mcg/kg in animal studies Routes Subcutaneous Oral Intraperitoneal Intravenous Common Vials 5mg 10mg Potential Benefits Accelerated tendon and ligament healing with improved biomechanical strength in preclinical soft-tissue injury models (PMID: 30915550) Gastric and GI mucosal cytoprotection against ethanol-induced lesions, mediated in part by the nitric oxide system (PMID: 30279308) Healing of cysteamine-induced colitis and colon anastomosis in preclinical inflammatory bowel disease models (PMID: 24304574) Neuroprotection with dopaminergic and nitric oxide-system modulation in central nervous system injury models such as stroke and dopamine-receptor blockade (PMID: 34380875) Promotion of angiogenesis via VEGFR2 up-regulation, internalization, and VEGFR2-Akt-eNOS signaling in rat hind-limb ischemia and endothelial assays (PMID: 27847966) Tendon fibroblast outgrowth, cell survival, and migration through FAK-paxillin pathway activation (PMID: 21030672) Growth hormone receptor up-regulation in tendon fibroblasts, potentiating growth hormone's proliferative effect (PMID: 25415472) Nitric oxide-system interaction with endothelium protection, angiogenesis, and EGR-1-mediated growth-factor and collagen expression (PMID: 22300085) Safety Notes Common Injection site redness or mild irritation (subcutaneous) Mild nausea with oral administration (rare) Transient lightheadedness reported anecdotally Serious No serious adverse events reported in IV pilot study (PMID: 40131143) No lethal dose (LD50) established in animal studies indicating very low acute toxicity No organ toxicity observed at supratherapeutic doses in rodent studies ### Overview BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a partial sequence of human gastric juice protein BPC. It has a molecular weight of 1419.53 Da and a CAS number of 137525-51-0. BPC-157 is classified as a stable gastric pentadecapeptide because it resists hydrolysis by gastric acid and digestive enzymes, a property that differentiates it from most bioactive peptides and enables oral bioavailability in preclinical models. As of 2026, BPC-157 has been investigated in more than 90 published preclinical studies spanning models of gastrointestinal injury, tendon and ligament damage, nerve injury, wound healing, and organ protection. A complete review by Sikiric et al. (2011) established BPC-157 as a peptide with broad cytoprotective and regenerative properties across multiple organ systems. Subsequent work by Seiwerth et al. (2022) expanded the evidence base to include vascular protection and modulation of the nitric oxide (NO) system as a central integrative mechanism. BPC-157 is not approved by the United States Food and Drug Administration (FDA) for any therapeutic indication. It is classified under the World Anti-Doping Agency (WADA) Prohibited List category S0 (non-approved substances), making it banned in competitive sport. Despite the lack of regulatory approval, BPC-157 is widely used in the research peptide and biohacking communities, primarily administered via subcutaneous injection or oral capsule for musculoskeletal recovery and gut healing. Preclinical studies have demonstrated that BPC-157 accelerates healing of transected rat Achilles tendons, with treated animals showing superior biomechanical tendon strength at 14 days post-injury compared to controls (PMID: 30915550). In gastrointestinal models, BPC-157 has shown protective effects against NSAID-induced gastric lesions, ethanol-induced mucosal damage, and inflammatory bowel disease (IBD) analogs including experimentally induced colitis. The peptide has also demonstrated neuroprotective activity in dopaminergic and serotonergic systems, counteracting lesions caused by neurotoxins in rodent models. A 2025 pilot safety study by Lee et al. represents the first published human intravenous (IV) administration data for BPC-157. In this small cohort, IV BPC-157 was administered at escalating doses with no serious adverse events reported and no clinically significant changes in laboratory parameters (PMID: 40131143). While this study was not powered to establish efficacy, it provided the first formal human safety signal for the peptide. BPC-157 has also been shown to upregulate growth hormone receptor (GHR) expression in animal models, suggesting a possible synergistic effect when combined with growth hormone secretagogues. The peptide is typically supplied as a lyophilized powder requiring reconstitution with bacteriostatic water. Lyophilized BPC-157 should be stored at -20 degrees Celsius in a desiccated environment; once reconstituted, it should be refrigerated at 2-8 degrees Celsius and used within 28 days to maintain peptide integrity. ### Potential Research Fields Wound healing Gastric ulcers Tendinopathy Neuroprotection IBD ## Chemical Information IUPAC Name L-valyl-L-lysyl-L-alanyl-L-arginyl-L-leucyl-L-histidyl-L-glycyl-L-lysyl-L-prolyl-L-alanyl-L-glycyl-L-glycyl-L-prolyl-L-prolyl-L-proline CAS Number 137525-51-0 Molecular Formula C62H98N16O22 Molecular Mass 1419.56 g/mol Image: BPC-157 molecular structure (https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/9941957/PNG?image_size=300x300) View on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/9941957 Amino Acid Sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV); 15-amino-acid pentadecapeptide, a partial sequence of human gastric juice protein BPC ## Dosing & Protocols ### Unlock the dosing protocols Enter your email to keep reading. It is free, and it opens these tabs on every compound page in this browser. - Dose, route, how often and how long - A titration schedule - Beginner, intermediate and advanced protocols - Reconstitution and handling notes You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) ## Research ### Unlock the research summary - A summary of the key research - Safety and side effects - A link to the PubMed results ## Interactions ### Interaction Matrix ### Contraindications Active cancer or history of cancer (due to angiogenic properties). Pregnancy or breastfeeding. Concurrent use of anticoagulants (may affect platelet function). Caution in patients with active infections where increased blood flow could spread pathogens. Research Disclaimer This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Best Price $34.99 up to $79.99 Best $/mg $2.3330 Vendors 7 Listings 15 vial, capsule Dosage Form Sort | Vendor | Product | Form | Qty | Price | $/mg | Coupon | | | --- | --- | --- | --- | --- | --- | --- | --- | | Image: ResearchChemHQ logo (https://staging.researchchemhq.co/wp/wp-content/uploads/2024/08/cropped-RCHQ-Invert-Logo-e1724477505900.png) ResearchChemHQ (https://www.bodyhackguide.co/vendors/researchchemhq) 100: https://www.bodyhackguide.co/vendor-trust-scorecard πŸ‡ΊπŸ‡Έ US | BPC-157 Capsules | capsule | 60 caps (500mcg each) ● In Stock | $79.99 | $2.67 | REDDIT | Buy: https://researchchemhq.co/product/bpc-157-caps/?ref=oyxnywoz | | Image: BHG Labs logo (https://bhglabs.co/store/wp-content/uploads/2026/06/logo-full.png) BHG Labs (https://www.bodyhackguide.co/vendors/bhg-labs) 70: https://www.bodyhackguide.co/vendor-trust-scorecard πŸ‡ΊπŸ‡Έ US | BPC-157 500mcg, 60 Dry-Fill Units | capsule | 60 dry-fill units ● In Stock | $69.99 VALUE | $2.33 | BHG20 | Buy: https://bhglabs.co/product/bpc-157-500mcg-60-dry-fill-units/?ref=zmgqyxku&coupon=BHG20 | | Image: Optimum Formula logo (https://optimumformula.co/wp-content/uploads/2025/07/LOGO-OPTIMUM-NEW.png) Optimum Formula (https://www.bodyhackguide.co/vendors/optimum-formula) 100: https://www.bodyhackguide.co/vendor-trust-scorecard πŸ‡ΊπŸ‡Έ US | BPC-157 10mg | vial | 5mg ● In Stock | $37.99 | $3.80 | REDDIT | Buy: https://optimumformula.co/product/bpc-157-10mg/?ref=ruyhjwqh | | Image: Optimum Formula logo (https://optimumformula.co/wp-content/uploads/2025/07/LOGO-OPTIMUM-NEW.png) Optimum Formula (https://www.bodyhackguide.co/vendors/optimum-formula) 100: https://www.bodyhackguide.co/vendor-trust-scorecard πŸ‡ΊπŸ‡Έ US | BPC-157 500mcg Capsules (60 ct, oral) | capsule | 60 capsules - 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Sign in (free, no spam) to share your experience with BPC-157. Current low $34.99 current listings 7-day low β€” not enough history yet 30-day low β€” not enough history yet 30-day change β€” not enough history yet Tracking since Mar 13, 2026 Β· 13 data points ## Price History 7 data points ### Vendors Selling BPC-157 #### Ion Peptide 4.5 3 listings Β· from $29.00 https://www.bodyhackguide.co/vendors/ion-peptide #### VANDL Labs 2 listings Β· from $34.99 https://www.bodyhackguide.co/vendors/vandl-labs #### BioMyst Labs 4.5 4 listings Β· from $34.99 https://www.bodyhackguide.co/vendors/biomyst-labs #### Optimum Formula 4.9 2 listings Β· from $37.99 https://www.bodyhackguide.co/vendors/optimum-formula #### Limitless Biochem EU 4.3 2 listings Β· from $53.50 https://www.bodyhackguide.co/vendors/limitless-biochem #### BHG Labs 4.8 1 listing Β· from $69.99 https://www.bodyhackguide.co/vendors/bhg-labs #### ResearchChemHQ 4.7 1 listing Β· from $79.99 https://www.bodyhackguide.co/vendors/researchchemhq How we score these vendors Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. View Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ### Related Compounds View All (https://www.bodyhackguide.co/wiki) ### TB-500 Injury, Repair & Recovery Phase 2 TB-500 is the name the market and the FDA use for a short synthetic fragment of thymosin beta-4: the seven-amino-acid, N-acetylated actin-binding sequence Ac-LKKTETQ (residues 17 to 23). tΒ½ Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure. 2000-5000 mcg (2-5 mg) subcutaneous 2x weekly loading; 2000 mcg (2 mg) weekly maintenance 1,039 PubMed View Profile https://www.bodyhackguide.co/compound/tb-500 ### Side-by-Side Comparisons All Comparisons (https://www.bodyhackguide.co/compare) BPC-157 vs TB-500: https://www.bodyhackguide.co/compare/bpc-157-vs-tb-500 BPC-157 vs Thymosin Alpha-1 (TA1): https://www.bodyhackguide.co/compare/thymosin-alpha-1-vs-bpc-157 BPC-157 vs LL-37: https://www.bodyhackguide.co/compare/ll-37-vs-bpc-157 BPC-157 vs KPV: https://www.bodyhackguide.co/compare/kpv-vs-bpc-157 View Full Dosage Guide β†’ Protocols, calculator & safety for BPC-157 https://www.bodyhackguide.co/guides/dosage/bpc-157 ### Related Articles All Posts (https://www.bodyhackguide.co/blog) #### The 8 Best Peptide Companies for Research: 2026 Purity & Price Comparison A data-driven comparison of every active peptide vendor we track: COA audit results, price-per-mg tables for 19 compounds, and a step-by-step purchase guide. 9/16/2026 https://www.bodyhackguide.co/blog/best-peptide-companies-2026 #### How to Reconstitute Peptides (Step-by-Step) How to reconstitute research peptides step by step: supplies, how much bacteriostatic water to use, mixing technique, and the mg/mL math with a worked example. For laboratory research use only. 7/7/2026 https://www.bodyhackguide.co/blog/how-to-reconstitute-peptides #### Gut Healing Supplements & Peptides: What the Research Actually Supports (2026) Most "gut healing" supplements and peptides are sold on animal studies and mechanism, not human results. The interventions with real human trial data are unglamorous and cheap: zinc-L-carnosine for the stomach lining, L-glutamine for a measured leaky gut, strain-specific probiotics, enteric-coated peppermint oil and the low-FODMAP diet for IBS, and soluble fiber done right. The hyped peptides (BPC-157, KPV) are almost entirely rat-and-petri-dish so far. And if your "stomach problem" is unexplained low iron or B12, the real issue might be too little stomach acid, which no supplement aisle fixes. 7/7/2026 https://www.bodyhackguide.co/blog/gut-healing-supplements-research-guide ### Featured Price βš—οΈ ResearchChemHQ $79.99($2.67/mg) 7 vendors Β· 15 listings ### Research Score 81 214 PubMed results ### Quality Indicators Data Completeness 100% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Results Interactions Vendor Listings COA Verification 10 Verified COAs 2 Vendors w/ COA High verification rate (83%) Latest test: 3/1/2026 Research Volume 214 PubMed results Well-researched compound ### Quick Facts Half-Life Molecular Weight 1419.56 g/mol Administration Subcutaneous, Oral, Intraperitoneal, Intravenous CAS Number 137525-51-0 Trial Phase Preclinical ### Safety Profile Common Side Effects - β€’ Injection site redness or mild irritation (subcutaneous) - β€’ Mild nausea with oral administration (rare) - β€’ Transient lightheadedness reported anecdotally Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. The Wolverine Stack: BPC-157 + TB-500 Protocol Guide Complete synergistic recovery protocol: dosing tables, cycling, reconstitution, and 9 PubMed citations. https://www.bodyhackguide.co/blog/wolverine-stack-bpc-157-tb-500-protocol-guide ## Frequently Asked Questions What is BPC-157 used for in research? BPC-157 is a synthetic peptide based on a sequence found in stomach protein. Most of the research looks at tissue repair, tendon and ligament healing, and gut protection. It is one of the most-studied recovery peptides. How is BPC-157 dosed in research protocols? Common research protocols use roughly 250 to 500 mcg per day subcutaneously, often near the area of interest. This site has a free reconstitution calculator that turns your vial size and target dose into exact syringe units. BPC-157 vs TB-500: should you stack them? They are frequently run together because they work through different mechanisms, BPC-157 more local and angiogenic, TB-500 more systemic. There is a full comparison and the popular 'Wolverine stack' protocol on the blog. ## Research Tools ### Peptide Calculator Reconstitution & syringe units https://www.bodyhackguide.co/tools/reconstitution ### Reconstitution Guide How to mix, step by step https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides ### Nasal Spray Calc mL per actuation https://www.bodyhackguide.co/tools/intranasal ### Half-Life Visualizer Decay curves https://www.bodyhackguide.co/tools/halflife ## Related Compounds ### TB-500 Injury, Repair & Recovery Phase 2 ## Side-by-Side Comparisons Compare BPC-157 head-to-head: mechanism, half-life, dosing, safety, and vendor prices. ## Research Benches Reference pages that put BPC-157 next to the compounds people pair it with: roles, evidence, overlap and conflicts. No dosing. Research use only. Tissue Repair Bench KLOW, GHK-Cu, BPC-157, TB-500, KPV and ARA-290, one name at a time research bench Β· no dosing https://www.bodyhackguide.co/stack/tissue-repair-bench Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Image: BodyHackGuide (https://www.bodyhackguide.co/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide #### Explore - Compare prices: https://www.bodyhackguide.co/compare - Vendors: https://www.bodyhackguide.co/vendors - Deals: https://www.bodyhackguide.co/deals - Coupons: https://www.bodyhackguide.co/coupons - Nootropics: https://www.bodyhackguide.co/nootropics - Brain health: https://www.bodyhackguide.co/brain-health - Blog: https://www.bodyhackguide.co/blog - Guides: https://www.bodyhackguide.co/guides #### Tools - Reconstitution: https://www.bodyhackguide.co/tools/reconstitution - Half-life visualizer: https://www.bodyhackguide.co/tools/halflife - COA reader: https://www.bodyhackguide.co/tools/coa - Cost calculator: https://www.bodyhackguide.co/tools/cost-calculator - Stack builder: https://www.bodyhackguide.co/stack-builder - All tools: https://www.bodyhackguide.co/tools #### Trust & vendors - Vendor directory: https://www.bodyhackguide.co/vendors - Trust scorecard: https://www.bodyhackguide.co/vendors/scorecard - Vendor trust badge: https://www.bodyhackguide.co/vendors/get-vetted - Scoring methodology: https://www.bodyhackguide.co/vendors/methodology - Peptide cheat sheet: https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download #### Company - About: https://www.bodyhackguide.co/about - Affiliate disclosure: https://www.bodyhackguide.co/affiliate-disclosure - Editorial standards: https://www.bodyhackguide.co/editorial-standards - Creators: https://www.bodyhackguide.co/creators - Coaches: https://www.bodyhackguide.co/coaches - 1-on-1 coaching: https://www.bodyhackguide.co/coaching - Privacy: https://www.bodyhackguide.co/privacy - Terms: https://www.bodyhackguide.co/terms - Full site directory: https://www.bodyhackguide.co/site-directory **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology), and we earn a commission from purchases made through some of our links at no extra cost to you. 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Β· Terms (https://www.bodyhackguide.co/terms) Β· Privacy (https://www.bodyhackguide.co/privacy) ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "BPC-157" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "BPC-157", "description": "BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a partial sequence of human gastric juice protein BPC. It has a molecular weight of 1419.53 Da and a CAS number of 137525-51-0. BPC-157 is classified as a stable gastric pentadecapeptide because it resists hydrolysis by gastric acid and digestive enzymes, a property that differentiates it from most bioactive peptides and enables oral bioavailability in preclinical models. As of 2026, BPC-157 has been investigated in more than 90 published preclinical studies spanning models of gastrointestinal injury, tendon and ligament damage, nerve injury, wound healing, and organ protection. A complete review by Sikiric et al. (2011) established BPC-157 as a peptide with broad cytoprotective and regenerative properties across multiple organ systems. Subsequent work by Seiwerth et al. (2022) expanded the evidence base to include vascular protection and modulation of the nitric oxide (NO) system as a central integrative mechanism. BPC-157 is not approved by the United States Food and Drug Administration (FDA) for any therapeutic indication. It is classified under the World Anti-Doping Agency (WADA) Prohibited List category S0 (non-approved substances), making it banned in competitive sport. Despite the lack of regulatory approval, BPC-157 is widely used in the research peptide and biohacking communities, primarily administered via subcutaneous injection or oral capsule for musculoskeletal recovery and gut healing. Preclinical studies have demonstrated that BPC-157 accelerates healing of transected rat Achilles tendons, with treated animals showing superior biomechanical tendon strength at 14 days post-injury compared to controls (PMID: 30915550). In gastrointestinal models, BPC-157 has shown protective effects against NSAID-induced gastric lesions, ethanol-induced mucosal damage, and inflammatory bowel disease (IBD) analogs including experimentally induced colitis. The peptide has also demonstrated neuroprotective activity in dopaminergic and serotonergic systems, counteracting lesions caused by neurotoxins in rodent models. A 2025 pilot safety study by Lee et al. represents the first published human intravenous (IV) administration data for BPC-157. In this small cohort, IV BPC-157 was administered at escalating doses with no serious adverse events reported and no clinically significant changes in laboratory parameters (PMID: 40131143). While this study was not powered to establish efficacy, it provided the first formal human safety signal for the peptide. BPC-157 has also been shown to upregulate growth hormone receptor (GHR) expression in animal models, suggesting a possible synergistic effect when combined with growth hormone secretagogues. The peptide is typically supplied as a lyophilized powder requiring reconstitution with bacteriostatic water. 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It has a molecular weight of 1419.53 Da and a CAS number of 137525-51-0. BPC-157 is classified as a stable gastric pentadecapeptide because it resists hydrolysis by gastric acid and digestive enzymes, a property that differentiates it from most bioactive peptides and enables oral bioavailability in preclinical models. As of 2026, BPC-157 has been investigated in more than 90 published preclinical studies spanning models of gastrointestinal injury, tendon and ligament damage, nerve injury, wound healing, and organ protection. A complete review by Sikiric et al. (2011) established BPC-157 as a peptide with broad cytoprotective and regenerative properties across multiple organ systems. Subsequent work by Seiwerth et al. (2022) expanded the evidence base to include vascular protection and modulation of the nitric oxide (NO) system as a central integrative mechanism. BPC-157 is not approved by the United States Food and Drug Administration (FDA) for any therapeutic indication. It is classified under the World Anti-Doping Agency (WADA) Prohibited List category S0 (non-approved substances), making it banned in competitive sport. Despite the lack of regulatory approval, BPC-157 is widely used in the research peptide and biohacking communities, primarily administered via subcutaneous injection or oral capsule for musculoskeletal recovery and gut healing. Preclinical studies have demonstrated that BPC-157 accelerates healing of transected rat Achilles tendons, with treated animals showing superior biomechanical tendon strength at 14 days post-injury compared to controls (PMID: 30915550). In gastrointestinal models, BPC-157 has shown protective effects against NSAID-induced gastric lesions, ethanol-induced mucosal damage, and inflammatory bowel disease (IBD) analogs including experimentally induced colitis. The peptide has also demonstrated neuroprotective activity in dopaminergic and serotonergic systems, counteracting lesions caused by neurotoxins in rodent models. A 2025 pilot safety study by Lee et al. represents the first published human intravenous (IV) administration data for BPC-157. In this small cohort, IV BPC-157 was administered at escalating doses with no serious adverse events reported and no clinically significant changes in laboratory parameters (PMID: 40131143). While this study was not powered to establish efficacy, it provided the first formal human safety signal for the peptide. BPC-157 has also been shown to upregulate growth hormone receptor (GHR) expression in animal models, suggesting a possible synergistic effect when combined with growth hormone secretagogues. The peptide is typically supplied as a lyophilized powder requiring reconstitution with bacteriostatic water. Lyophilized BPC-157 should be stored at -20 degrees Celsius in a desiccated environment; once reconstituted, it should be refrigerated at 2-8 degrees Celsius and used within 28 days to maintain peptide integrity.", "lastReviewed": "2026-05-04T11:34:22.098+00:00", "url": "https://www.bodyhackguide.co/compound/bpc-157", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "BPC-157", "alternateName": [ "BPC", "BPC-157 Capsules", "BPC-157 500mcg Capsules", "Pentadecapeptide", "Repair Balm", "Oral BPC-157", "BPC-157 Oral", "Body Protection Compound" ], "description": "BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a partial sequence of human gastric juice protein BPC. It has a molecular weight of 1419.53 Da and a CAS number of 137525-51-0. BPC-157 is classified as a stable gastric pentadecapeptide because it resists hydrolysis by gastric acid and digestive enzymes, a property that differentiates it from most bioactive peptides and enables oral bioavailability in preclinical models. As of 2026, BPC-157 has been investigated in more than 90 published preclinical studies spanning models of gastrointestinal injury, tendon and ligament damage, nerve injury, wound healing, and organ protection. A complete review by Sikiric et al. (2011) established BPC-157 as a peptide with broad cytoprotective and regenerative properties across multiple organ systems. Subsequent work by Seiwerth et al. (2022) expanded the evidence base to include vascular protection and modulation of the nitric oxide (NO) system as a central integrative mechanism. BPC-157 is not approved by the United States Food and Drug Administration (FDA) for any therapeutic indication. It is classified under the World Anti-Doping Agency (WADA) Prohibited List category S0 (non-approved substances), making it banned in competitive sport. Despite the lack of regulatory approval, BPC-157 is widely used in the research peptide and biohacking communities, primarily administered via subcutaneous injection or oral capsule for musculoskeletal recovery and gut healing. Preclinical studies have demonstrated that BPC-157 accelerates healing of transected rat Achilles tendons, with treated animals showing superior biomechanical tendon strength at 14 days post-injury compared to controls (PMID: 30915550). In gastrointestinal models, BPC-157 has shown protective effects against NSAID-induced gastric lesions, ethanol-induced mucosal damage, and inflammatory bowel disease (IBD) analogs including experimentally induced colitis. The peptide has also demonstrated neuroprotective activity in dopaminergic and serotonergic systems, counteracting lesions caused by neurotoxins in rodent models. A 2025 pilot safety study by Lee et al. represents the first published human intravenous (IV) administration data for BPC-157. In this small cohort, IV BPC-157 was administered at escalating doses with no serious adverse events reported and no clinically significant changes in laboratory parameters (PMID: 40131143). While this study was not powered to establish efficacy, it provided the first formal human safety signal for the peptide. BPC-157 has also been shown to upregulate growth hormone receptor (GHR) expression in animal models, suggesting a possible synergistic effect when combined with growth hormone secretagogues. The peptide is typically supplied as a lyophilized powder requiring reconstitution with bacteriostatic water. Lyophilized BPC-157 should be stored at -20 degrees Celsius in a desiccated environment; once reconstituted, it should be refrigerated at 2-8 degrees Celsius and used within 28 days to maintain peptide integrity.", "activeIngredient": "BPC-157", "administrationRoute": "Subcutaneous, Oral, Intraperitoneal, Intravenous", "mechanismOfAction": "Nitric Oxide (NO) System Modulation BPC-157 exerts a central integrative effect through modulation of the nitric oxide system. Studies by Seiwerth et al. (2022) demonstrated that BPC-157 counteracts both NO-excess and NO-deficiency states, functioning as a stabilizer of the NO system rather than a simple agonist or antagonist. This bidirectional NO modulation is proposed as the mechanism underlying BPC-157's ability to protect against diverse insults including ischemia-reperfusion injury, endothelial dysfunction, and vasospasm. BPC-157 interacts with the eNOS pathway, maintaining vascular homeostasis and supporting angiogenesis in damaged tissues. VEGFR2 and Angiogenesis Pathway BPC-157 significantly upregulates vascular endothelial growth factor receptor 2 (VEGFR2) expression in injured tissues. This leads to enhanced angiogenesis β€” the formation of new blood vessels β€” which is critical for tissue repair in tendons, ligaments, muscle, and gastrointestinal mucosa. In rat tendon transection models, BPC-157-treated animals exhibited greater capillary density at the repair site at 14 days post-injury. The pro-angiogenic effect operates through VEGF-VEGFR2-mediated endothelial cell proliferation and tube formation. EGR-1 Transcription Factor and FAK-Paxillin Signaling BPC-157 stimulates early growth response gene 1 (EGR-1), a transcription factor involved in wound healing, cell proliferation, and differentiation. EGR-1 activation leads to downstream upregulation of cytokines and growth factors critical for tissue remodeling. Additionally, BPC-157 activates the focal adhesion kinase (FAK)-paxillin pathway, which governs cell adhesion, migration, and extracellular matrix reorganization. This signaling cascade is particularly important in tendon healing, where collagen fiber realignment depends on mechanotransduction signaling through focal adhesions. Growth Hormone Receptor Upregulation BPC-157 has been demonstrated to upregulate growth hormone receptor (GHR) expression in animal tissues. This finding suggests that BPC-157 may potentiate the local effects of circulating growth hormone and IGF-1, improving tissue repair capacity beyond what the peptide achieves through its direct signaling pathways. This GHR upregulation may also explain the anecdotal synergy reported when BPC-157 is co-administered with growth hormone secretagogues such as ipamorelin or CJC-1295. Neuroprotective Mechanisms BPC-157 interacts with the dopaminergic and serotonergic neurotransmitter systems. In rodent models of neurotoxin-induced dopaminergic lesions (analogous to Parkinson's disease), BPC-157 provided significant neuroprotection, maintaining dopaminergic neuron viability and motor function. The peptide also modulates serotonin turnover, exerting antidepressant-like and anxiolytic-like effects in behavioral testing paradigms. These central nervous system effects are thought to be mediated through GABAergic modulation and direct interaction with dopamine transporter and receptor expression.", "dosageForm": "vial, capsule", "legalStatus": "Not approved for human use (research chemical)", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is BPC-157 used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "BPC-157 is a synthetic peptide based on a sequence found in stomach protein. Most of the research looks at tissue repair, tendon and ligament healing, and gut protection. It is one of the most-studied recovery peptides." } }, { "@type": "Question", "name": "How is BPC-157 dosed in research protocols?", "acceptedAnswer": { "@type": "Answer", "text": "Common research protocols use roughly 250 to 500 mcg per day subcutaneously, often near the area of interest. This site has a free reconstitution calculator that turns your vial size and target dose into exact syringe units." } }, { "@type": "Question", "name": "BPC-157 vs TB-500: should you stack them?", "acceptedAnswer": { "@type": "Answer", "text": "They are frequently run together because they work through different mechanisms, BPC-157 more local and angiogenic, TB-500 more systemic. 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