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5.  AHK-Cu 

# AHK-Cu

Skin & Hair Preclinical 

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Also known as: Copper Tripeptide-2, Ala-His-Lys-Cu, AHK Copper Peptide, Copper Tripeptide AHK 

AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). Where GHK-Cu is the most-studied copper peptide and naturally occurs in human plasma, AHK-Cu is a synthetic structural analog with enhanced copper-chelating affinity.

Half-Life:  Unknown (topical half-life, follicular retention not well characterized) Route:  Topical, Subcutaneous, Intradermal MW:  Free peptide (AHK): 354.41 Da (C15H26N6O4). Copper complex (AHK-Cu): 415.9 Da (C15H24CuN6O4, neutral 1:1 Cu(II) complex - Cu(II) displaces two protons from the tripeptide ligand). 

Last reviewed: Sep 3, 2026 

[

Skin & Hair

Category



](/wiki#cat-skin-&-hair)

Preclinical

Research Stage

OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices3 Related

## Overview

### Best Price Available

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$63.00

1 vial · vial

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### At A Glance

Mechanism 

AHK-Cu delivers bioavailable copper ions to follicular and dermal tissues. Copper acts as a cofactor for lysyl oxidase (collagen/elastin crosslinking), superoxide dismutase (antioxidant), and vascular endothelial growth factor (VEGF) signaling. The tripeptide backbone penetrates … 

Half-Life 

Unknown (topical half-life, follicular retention not well characterized)

Dosing 

once daily

Dose Range 

0mcg 

Routes 

Topical Subcutaneous Intradermal 

Common Vials 

50mg 100mg 

Potential Benefits 

Hair follicle stimulation — activates anagen phase via Wnt/β-catenin in dermal papilla cells Reduction of follicle miniaturization in androgenetic alopecia models Enhanced scalp vascularity via VEGF upregulation Wound healing acceleration — copper cofactor for lysyl oxidase and collagen maturation Synergistic with GHK-Cu in multi-peptide scalp formulations 

Safety Notes 

Common 

Mild scalp irritation at high concentrations (>1%) Temporary skin discoloration with copper accumulation 

Serious 

No systemic toxicity documented at topical doses Very low absorption through intact skin 

### Overview

AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). Where GHK-Cu is the most-studied copper peptide and naturally occurs in human plasma, AHK-Cu is a synthetic structural analog with enhanced copper-chelating affinity. Both peptides activate hair follicle stem cells and promote keratinocyte proliferation, but AHK-Cu appears to have stronger follicle-stimulating activity in some preclinical comparisons. Research applications center on androgenetic alopecia, scalp vascularity, and wound healing, typically in topical formulations or via mesotherapy injection. AHK-Cu is used in cosmetic compounding for scalp treatments targeting hair miniaturization.

## Chemical Information

IUPAC Name

Not yet available 

CAS Number

Not yet available 

Molecular Formula

Not yet available 

Molecular Mass

415.94 g/mol

Amino Acid Sequence

Ala-His-Lys (AHK); alanyl-L-histidyl-L-lysine. AHK-Cu is the 1:1 copper(II) chelate of this tripeptide.

## Dosing & Protocols

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## Interactions

Interaction and contraindication data is being compiled for AHK-Cu. Check back soon.

General Safety Note

Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.

Best Price 

$63.00

up to $93.00

Best $/mg 

$0.0650

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$/mg

Coupon

![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg)

[Ion Peptide](/vendor/ion-peptide)

[70 ](/vendor-trust-scorecard)

🇺🇸 US 🌍 International 

AHK-Cu 50mg

vial 

1 vial ● Out of Stock 

$63.00 BEST 

$1.260

— 

[Sign in for stock alert](/auth)

![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg)

[Ion Peptide](/vendor/ion-peptide)

[70 ](/vendor-trust-scorecard)

🇺🇸 US 🌍 International 

AHK-Cu Raw 1g

powder 

1g ● In Stock 

$65.00 VALUE 

$0.065

— 

[Buy](https://ionpeptide.com/product/ahk-cu-raw-1g/?ref=reddit15)

![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg)

[Ion Peptide](/vendor/ion-peptide)

[70 ](/vendor-trust-scorecard)

🇺🇸 US 🌍 International 

AHK-Cu 100mg

vial 

1 vial ● In Stock 

$93.00 

$0.930

— 

[Buy](https://ionpeptide.com/product/ahk-cu-100mg/?ref=reddit15)

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Current low

$65.00

as of Apr 22, 2026

7-day low

—

no 7d data yet

30-day low

—

no 30d data yet

30-day change

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baseline building

Tracking since Apr 22, 2026 · 3 data points

### Vendors Selling AHK-Cu

[

![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg)

#### Ion Peptide

4.5 

3 listings · from $63.00 





](/vendor/ion-peptide)

How we score these vendors

Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.

[View Scorecard](/vendors/scorecard)

### Related Compounds

[View All](/wiki)

[

### Acetyl Hexapeptide-8

Skin & Hair Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. 

Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction.

t½ Short (topical application, no systemic absorption at cosmetic doses)  0 

Preclinical View Profile 

](/compound/acetyl-hexapeptide-8)[

### Melanotan 2

Skin & Hair Discontinued (early clinical) 

A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression..

t½ ~1–2 hours  100-1,000 mcg per injection 

Preclinical View Profile 

](/compound/melanotan-2)[

### Minoxidil

Skin & Hair FDA-Approved 

Minoxidil is an FDA-approved treatment for pattern hair loss.

t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use.  Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically. 

Preclinical View Profile 

](/compound/minoxidil)[

### PDRN

Skin & Hair Phase 4 

PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation.

t½ Short (oligonucleotides degraded rapidly; tissue effects persist longer)  0 

Preclinical View Profile 

](/compound/pdrn)[

### Snap-8

Skin & Hair Preclinical 

Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).

t½ Not characterized (topical peptide)  0 

Preclinical View Profile 

](/compound/snap-8)

### Side-by-Side Comparisons

[All Comparisons](/compare)

[AHK-Cu vs GHK-Cu](/compare/ghk-cu-vs-ahk-cu "GHK CU vs AHK CU")

[

View Full Dosage Guide →

Protocols, calculator & safety for AHK-Cu



](/guides/dosage/ahk-cu)

### Best Price

![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg)

Ion Peptide

$63.00

[Buy Now](https://ionpeptide.com/product/ahk-cu-100mg/?ref=reddit15)

1 vendors · 3 listings

### Research Score

45 

0 PubMed studies

### Quality Indicators

Data Completeness

63% 

Description 

Mechanism of Action 

Chemical Data 

Dosing Protocols 

Safety Profile 

PubMed Studies 

Interactions 

Vendor Listings 

### Quick Facts

Half-Life

Unknown (topical half-life, follicular retention not well characterized)

Molecular Weight

415.94 g/mol

Administration

Topical, Subcutaneous, Intradermal

Trial Phase

Preclinical

### Safety Profile

Common Side Effects

-   •  Mild scalp irritation at high concentrations (>1%)
-   •  Temporary skin discoloration with copper accumulation

[Full Dosage Guide](/guides/dosage/ahk-cu)[Calculate Your Dose](/tools/reconstitution)

Research Disclaimer

This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

## Frequently Asked Questions

What is AHK-Cu used for in research?

AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). Where GHK-Cu is the most-studied copper peptide and naturally occurs in human plasma, AHK-Cu is a synthetic structural analog with enhanced copper-chelating affinity. Both peptides activate hair follicle stem cells and promote keratinocyte proliferation, but AHK-Cu appears to have stronger follicle-stimulating activity in some preclinical comparisons. Research applications center on androgenetic alopecia, scalp vascularity, and wound healing, typically in topical formulations or via mesotherapy injection. AHK-Cu is used in cosmetic compounding for scalp treatments targeting hair miniaturization.

What forms does AHK-Cu come in?

AHK-Cu is available in vial, powder forms.

How much does AHK-Cu cost?

Prices start at $63.00 across 1 verified vendor.

How do I compare AHK-Cu vendors?

Compare prices, payment methods, shipping, and COA scores across 1 vendor.

## Research Tools

[

### Peptide Calculator

Reconstitution & syringe units



](/tools/reconstitution)[

### Reconstitution Guide

How to mix, step by step



](/guides/how-to-reconstitute-peptides)[

### Nasal Spray Calc

mL per actuation



](/tools/intranasal)[

### Half-Life Visualizer

Decay curves



](/tools/halflife)

## Related Compounds

[View All](/wiki)

[

### Acetyl Hexapeptide-8

Skin & Hair Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. 

Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction.

t½ Short (topical application, no systemic absorption at cosmetic doses)  0 

Preclinical View Profile 

](/compound/acetyl-hexapeptide-8)[

### Melanotan 2

Skin & Hair Discontinued (early clinical) 

A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression..

t½ ~1–2 hours  100-1,000 mcg per injection 

Preclinical View Profile 

](/compound/melanotan-2)[

### Minoxidil

Skin & Hair FDA-Approved 

Minoxidil is an FDA-approved treatment for pattern hair loss.

t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use.  Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically. 

Preclinical View Profile 

](/compound/minoxidil)[

### PDRN

Skin & Hair Phase 4 

PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation.

t½ Short (oligonucleotides degraded rapidly; tissue effects persist longer)  0 

Preclinical View Profile 

](/compound/pdrn)[

### Snap-8

Skin & Hair Preclinical 

Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).

t½ Not characterized (topical peptide)  0 

Preclinical View Profile 

](/compound/snap-8)

## Side-by-Side Comparisons

[All Comparisons](/compare)

Compare AHK-Cu head-to-head: mechanism, half-life, dosing, safety, and live pricing.

[AHK-Cu vs GHK-Cu](/compare/ghk-cu-vs-ahk-cu "GHK CU vs AHK CU")

Free 2026 Peptide Cheat Sheet — 50 pages, PDF

Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one.

[Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-ahk-cu)

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Tools

#### Tools

-   [Reconstitution](/tools/reconstitution)
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Trust & vendors

#### Trust & vendors

-   [Vendor directory](/vendors)
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Company

#### Company

-   [About](/about)
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**Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell, distribute, or promote any products. Always consult a qualified healthcare professional and comply with local regulations.

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