--- title: "Acetyl Hexapeptide-8: Dosage, Side Effects & Prices" url: https://www.bodyhackguide.co/compound/acetyl-hexapeptide-8 description: "Acetyl Hexapeptide-8: dosing protocols, mechanism & side effects. Compare 1 current vendor prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Acetyl Hexapeptide-8 Skin & Hair: https://www.bodyhackguide.co/wiki#cat-skin-&-hair Status Cosmetic ingredient Evidence Small human cosmetic trials, graded on the Peptides for Skin bench (https://www.bodyhackguide.co/stack/skin-peptides) Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Reviewed 25 October 2026 01 Overview ## What Acetyl Hexapeptide-8 is Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation. ### How it works Acetyl Hexapeptide-8 (Argireline) is patterned after the N-terminal domain of SNAP-25 and behaves as a competitive mimic of that protein during SNARE complex assembly. The SNARE complex (SNAP-25 + Syntaxin-1 + VAMP/synaptobrevin) is required for synaptic-vesicle docking and fusion, which drives acetylcholine release at the neuromuscular junction (and catecholamine release from neurosecretory cells in the original mechanistic work). By interfering with formation of the ternary SNARE complex, the peptide is proposed to reduce neurotransmitter release and dampen contraction of facial expression muscles (e.g., orbicularis oculi, frontalis, corrugator), softening the depth and frequency of dynamic wrinkles. The effect is presented as reversible and dose-dependent - unlike botulinum toxin type A, which proteolytically cleaves SNAP-25 until the protein is resynthesized, this peptide does not enzymatically destroy SNARE proteins. Important caveat: most mechanistic data are in vitro/ex vivo, and topical skin-penetration studies show the peptide remains largely in the stratum corneum, so how much reaches facial muscle in vivo is uncertain. ### Benefits listed - Targets dynamic expression wrinkles - forehead, glabellar, and periorbital (crow's feet) lines - Proposed to reduce facial neuromuscular signaling by destabilizing the ternary SNARE complex (acts as a SNAP-25 N-terminal mimic) - A randomized, placebo-controlled human study reported ~49% subjective improvement in periorbital wrinkles vs 0% for placebo over 4 weeks (small evidence base) [PMID: 23417317] - Marketed as a topical 'Botox alternative' - reversible mechanism, not a neurotoxin, with no botulinum-type systemic risk Show 2 more Show less - Supplied as a raw cosmetic-compounding powder for research/formulation use (verify purity via HPLC COA) - Commonly combined with related peptides (e.g., Acetyl Octapeptide-3 / Snap-8) in anti-wrinkle formulations 02 Research Free with email ## What the research shows ### Graded on a research bench Reference pages that put Acetyl Hexapeptide-8 next to the compounds people pair it with: roles, evidence, overlap and conflicts. No dosing. Research use only. - Peptides for Skin Small human cosmetic trials human data on 4 of 6 compounds on the bench: https://www.bodyhackguide.co/stack/skin-peptides ### Unlock the research summary Enter your email to keep reading. It is free, and it opens these sections on every compound page in this browser. - A summary of the key research - A link to the PubMed results You also get the free peptide cheat sheet by email. Unsubscribe anytime. Have an account? Sign in (https://www.bodyhackguide.co/auth) 03 Safety ## Acetyl Hexapeptide-8 side effects and interactions ### Side effects #### Common - Well tolerated in clinical cosmetic literature - Mild transient erythema at high concentrations #### Serious events - No systemic adverse events at topical cosmetic doses - Not for injection use ### Interactions Not in our record Our record lists no interactions for Acetyl Hexapeptide-8. That means none are recorded here, not that none exist. This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds. Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. Order Bloodwork (https://anabolicinsights.ai/?ref=nwm2zjb) 04 Dosing Free with email ## Acetyl Hexapeptide-8 dosage and protocols Dosing Twice daily ### Unlock the Dosing section - Route and how often 05 Prices ## Acetyl Hexapeptide-8 prices 1 listing from 1 vendor, opening in the Featured order. Pack prices $129.00 Lowest per mg $0.129/mg Vendors 1 Listings 1 (powder) Prices as the vendors list them, last recorded 22 April 2026. Form Sort | Vendor | Product | Price | Buy | | --- | --- | --- | --- | | Image: Ion Peptide logo (https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide: https://www.bodyhackguide.co/vendors/ion-peptide | Acetyl Hexapeptide-8 Raw 1g powder, 1g In stock | $0.129/mg $129.00 Lowest per mg | Buy Acetyl Hexapeptide-8 Raw 1g at Ion Peptide: https://ionpeptide.com/product/acetyl-hexapeptide-8-raw-1g/?ref=reddit15 | Vendors selling Acetyl Hexapeptide-8(1: trust score, certificates, payment, shipping) - Ion Peptide (https://www.bodyhackguide.co/vendors/ion-peptide)1 listing, from $129.00 Trust Score 70/100 (https://www.bodyhackguide.co/vendor-trust-scorecard), no certificate records on file, pays by card, crypto, ACH, ships to the US, international destinations Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. How we score these vendors (https://www.bodyhackguide.co/vendors/scorecard) Review Acetyl Hexapeptide-8 ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Acetyl Hexapeptide-8. 06 Chemistry ## Chemistry and structure Molecular mass 888.99 g/mol Amino acid sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 (Ac-EEMQRR-NH2); N-terminally acetylated, C-terminally amidated synthetic hexapeptide patterned after the N-terminal domain of SNAP-25 Half-life Short (topical application, no systemic absorption at cosmetic doses) 07 Related ## Related to Acetyl Hexapeptide-8 ### In the same category - AHK-CuPreclinical AHK-Cu is a copper chelating tripeptide related to but distinct from GHK-Cu.: https://www.bodyhackguide.co/compound/ahk-cu - Melanotan 2Discontinued A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression.: https://www.bodyhackguide.co/compound/melanotan-2 - MinoxidilFDA-Approved Minoxidil is an FDA-approved treatment for pattern hair loss. Originally an oral blood-pressure drug, its hair-growth side effect led to the topical products (Rogaine) at 2% and 5%.: https://www.bodyhackguide.co/compound/minoxidil - Palmitoyl Pentapeptide-4Marketed topical cosmetic ingredient with a small set of human cosmetic trials Palmitoyl pentapeptide-4 is the cosmetic ingredient Pal-KTTKS, a five-amino-acid fragment of the type I collagen propeptide with a 16-carbon palmitic acid chain attached, sold to formulators under the trade name Matrixyl (PubChem CID 9897237; PMID: 8486721).: https://www.bodyhackguide.co/compound/palmitoyl-pentapeptide-4 - PDRNPhase 4 PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation.: https://www.bodyhackguide.co/compound/pdrn - PTD-DBMPreclinical PTD-DBM is a synthetic peptide that joins a protein transduction domain, which carries the peptide into cells, to the Dishevelled-binding motif (DBM) of the protein CXXC5, and it was built to block CXXC5 from binding Dishevelled so that Wnt/beta-catenin signalling stays switched on.: https://www.bodyhackguide.co/compound/ptd-dbm All compounds (https://www.bodyhackguide.co/wiki) ### Compare Acetyl Hexapeptide-8 - Alternatives to Acetyl Hexapeptide-8: https://www.bodyhackguide.co/alternatives-to/acetyl-hexapeptide-8 ### Research tools - Peptide Calculator Reconstitution and syringe units: https://www.bodyhackguide.co/tools/reconstitution - Reconstitution Guide How to mix, step by step: https://www.bodyhackguide.co/guides/how-to-reconstitute-peptides - Nasal Spray Calc mL per actuation: https://www.bodyhackguide.co/tools/intranasal - Half-Life Visualizer Decay curves: https://www.bodyhackguide.co/tools/halflife All articles (https://www.bodyhackguide.co/blog) 08 Questions ## Frequently asked questions What is Acetyl Hexapeptide-8 used for in research? Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation. What forms does Acetyl Hexapeptide-8 come in? Acetyl Hexapeptide-8 is available in powder form. How do I compare Acetyl Hexapeptide-8 vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. How many vendors sell Acetyl Hexapeptide-8, and what does it cost per mg? 1 of the vendors BodyHackGuide tracks list Acetyl Hexapeptide-8 (1 listing). Among BodyHackGuide's Acetyl Hexapeptide-8 listings recorded as in stock with a milligram count, the lowest price per milligram is $0.129/mg at Ion Peptide and the median is $0.129/mg. The Acetyl Hexapeptide-8 prices on BodyHackGuide are vendors' listed prices as BodyHackGuide last recorded them, not transactions; the most recent recorded change to a Acetyl Hexapeptide-8 listing is dated 22 April 2026. Which vendors have third-party COAs for Acetyl Hexapeptide-8 on file at BodyHackGuide? BodyHackGuide holds no third-party certificate records for Acetyl Hexapeptide-8. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor. Free 2026 Peptide Cheat Sheet (PDF) 38 compounds and blends: vial sizes, BAC water volumes, dosing ranges and bloodwork markers. Download Free (https://www.bodyhackguide.co/guides/peptide-cheat-sheet-download) BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. 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