--- title: "Acetyl Hexapeptide-8: Dosing & Vendor Prices" description: "Acetyl Hexapeptide-8: dosing protocols, mechanism & side effects. Compare 1 verified vendor prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compounds", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Acetyl Hexapeptide-8" } ] }, { "@context": "https://schema.org", "@type": "Product", "name": "Acetyl Hexapeptide-8", "description": "Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.", "url": "https://www.bodyhackguide.co/compound/acetyl-hexapeptide-8", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "129.00", "highPrice": "129.00", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "129.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/acetyl-hexapeptide-8-raw-1g/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Acetyl Hexapeptide-8 1000mg powder" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Acetyl Hexapeptide-8", "description": "Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.", "lastReviewed": "2026-09-04T09:45:04.637Z", "url": "https://www.bodyhackguide.co/compound/acetyl-hexapeptide-8", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Acetyl Hexapeptide-8", "alternateName": [ "Argireline", "Acetyl Hexapeptide-3", "SNAP-6", "Botox peptide", "Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2" ], "description": "Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.", "activeIngredient": "Acetyl Hexapeptide-8", "administrationRoute": "Topical", "mechanismOfAction": "Acetyl Hexapeptide-8 (Argireline) is patterned after the N-terminal domain of SNAP-25 and behaves as a competitive mimic of that protein during SNARE complex assembly. The SNARE complex (SNAP-25 + Syntaxin-1 + VAMP/synaptobrevin) is required for synaptic-vesicle docking and fusion, which drives acetylcholine release at the neuromuscular junction (and catecholamine release from neurosecretory cells in the original mechanistic work). By interfering with formation of the ternary SNARE complex, the peptide is proposed to reduce neurotransmitter release and dampen contraction of facial expression muscles (e.g., orbicularis oculi, frontalis, corrugator), softening the depth and frequency of dynamic wrinkles. The effect is presented as reversible and dose-dependent - unlike botulinum toxin type A, which proteolytically cleaves SNAP-25 until the protein is resynthesized, this peptide does not enzymatically destroy SNARE proteins. Important caveat: most mechanistic data are in vitro/ex vivo, and topical skin-penetration studies show the peptide remains largely in the stratum corneum, so how much reaches facial muscle in vivo is uncertain.", "dosageForm": "powder", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Acetyl Hexapeptide-8 used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation." } }, { "@type": "Question", "name": "What forms does Acetyl Hexapeptide-8 come in?", "acceptedAnswer": { "@type": "Answer", "text": "Acetyl Hexapeptide-8 is available in powder form." } }, { "@type": "Question", "name": "How much does Acetyl Hexapeptide-8 cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $129.00 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare Acetyl Hexapeptide-8 vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" }, { "@context": "https://schema.org", "@type": "Product", "name": "Acetyl Hexapeptide-8", "description": "Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.", "url": "https://www.bodyhackguide.co/compound/acetyl-hexapeptide-8", "image": "https://www.bodyhackguide.co/og-image.png", "brand": { "@type": "Brand", "name": "Research Compound" }, "offers": { "@type": "AggregateOffer", "lowPrice": "129.00", "highPrice": "129.00", "priceCurrency": "USD", "offerCount": "1", "availability": "https://schema.org/InStock", "offers": [ { "@type": "Offer", "price": "129.00", "priceCurrency": "USD", "availability": "https://schema.org/InStock", "itemCondition": "https://schema.org/NewCondition", "url": "https://ionpeptide.com/product/acetyl-hexapeptide-8-raw-1g/?ref=reddit15", "seller": { "@type": "Organization", "name": "Ion Peptide", "url": "https://ionpeptide.com" }, "name": "Acetyl Hexapeptide-8 1000mg powder" } ] } }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Acetyl Hexapeptide-8", "description": "Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.", "lastReviewed": "2026-09-04T09:45:04.637Z", "url": "https://www.bodyhackguide.co/compound/acetyl-hexapeptide-8", "author": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "reviewedBy": { "@type": "Person", "name": "BioChonch", "url": "https://www.bodyhackguide.co/about", "jobTitle": "Founder & Lead Researcher", "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher" ], "worksFor": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" } }, "publisher": { "@type": "Organization", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainContentOfPage": { "@type": "WebPageElement", "cssSelector": "main" }, "about": { "@type": "Drug", "name": "Acetyl Hexapeptide-8", "alternateName": [ "Argireline", "Acetyl Hexapeptide-3", "SNAP-6", "Botox peptide", "Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2" ], "description": "Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.", "activeIngredient": "Acetyl Hexapeptide-8", "administrationRoute": "Topical", "mechanismOfAction": "Acetyl Hexapeptide-8 (Argireline) is patterned after the N-terminal domain of SNAP-25 and behaves as a competitive mimic of that protein during SNARE complex assembly. The SNARE complex (SNAP-25 + Syntaxin-1 + VAMP/synaptobrevin) is required for synaptic-vesicle docking and fusion, which drives acetylcholine release at the neuromuscular junction (and catecholamine release from neurosecretory cells in the original mechanistic work). By interfering with formation of the ternary SNARE complex, the peptide is proposed to reduce neurotransmitter release and dampen contraction of facial expression muscles (e.g., orbicularis oculi, frontalis, corrugator), softening the depth and frequency of dynamic wrinkles. The effect is presented as reversible and dose-dependent - unlike botulinum toxin type A, which proteolytically cleaves SNAP-25 until the protein is resynthesized, this peptide does not enzymatically destroy SNARE proteins. Important caveat: most mechanistic data are in vitro/ex vivo, and topical skin-penetration studies show the peptide remains largely in the stratum corneum, so how much reaches facial muscle in vivo is uncertain.", "dosageForm": "powder", "legalStatus": "Not approved for human use — research chemical", "warning": "For research purposes only. Not for human consumption." } }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is Acetyl Hexapeptide-8 used for in research?", "acceptedAnswer": { "@type": "Answer", "text": "Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation." } }, { "@type": "Question", "name": "What forms does Acetyl Hexapeptide-8 come in?", "acceptedAnswer": { "@type": "Answer", "text": "Acetyl Hexapeptide-8 is available in powder form." } }, { "@type": "Question", "name": "How much does Acetyl Hexapeptide-8 cost?", "acceptedAnswer": { "@type": "Answer", "text": "Prices start at $129.00 across 1 verified vendor." } }, { "@type": "Question", "name": "How do I compare Acetyl Hexapeptide-8 vendors?", "acceptedAnswer": { "@type": "Answer", "text": "Compare prices, payment methods, shipping, and COA scores across 1 vendor." } } ] }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompound%2Facetyl-hexapeptide-8) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compounds](/compare) 3. Acetyl Hexapeptide-8 ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Best price right now $0.13/mg · $129.00 for 1000mg at Ion Peptide [Buy at Ion Peptide](https://www.bodyhackguide.co/go/ion-peptide?utm_source=compound-sticky-bar&utm_campaign=4e90b168-0ee9-4c8c-846d-ecacb3e10710&utm_medium=best-price-cta) [Where to buy Acetyl Hexapeptide-8](/buy/acetyl-hexapeptide-8) [Acetyl Hexapeptide-8 coupon codes](/coupons/acetyl-hexapeptide-8) [Acetyl Hexapeptide-8 protocol](/protocol/acetyl-hexapeptide-8) [Alternatives to Acetyl Hexapeptide-8](/alternatives-to/acetyl-hexapeptide-8) [Acetyl Hexapeptide-8 side effects](/side-effects/acetyl-hexapeptide-8) 1. [Home](/) 3. [Compounds](/compare) 5. Acetyl Hexapeptide-8 # Acetyl Hexapeptide-8 Skin & Hair Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. Download PDF Also known as: Argireline, Acetyl Hexapeptide-3, SNAP-6, Botox peptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Half-Life: Short (topical application, no systemic absorption at cosmetic doses) Route: Topical MW: 888.99 g/mol (average); molecular formula C34H60N14O12S Last reviewed: Sep 3, 2026 [ Skin & Hair Category ](/wiki#cat-skin-&-hair) Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. Research Stage OverviewChemical InfoDosing & ProtocolsInteractionsResearchCompare Prices1 Related ## Overview ### Best Price Available ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide $129.00 1g · powder [Buy Now](https://ionpeptide.com/product/acetyl-hexapeptide-8-raw-1g/?ref=reddit15) Compare 1 vendor ### At A Glance Mechanism Acetyl Hexapeptide-8 (Argireline) is patterned after the N-terminal domain of SNAP-25 and behaves as a competitive mimic of that protein during SNARE complex assembly. The SNARE complex (SNAP-25 + Syntaxin-1 + VAMP/synaptobrevin) is required for synaptic-vesicle docking and fusio… Half-Life Short (topical application, no systemic absorption at cosmetic doses) Dosing twice daily Dose Range 0mcg Routes Topical Potential Benefits Targets dynamic expression wrinkles - forehead, glabellar, and periorbital (crow's feet) lines Proposed to reduce facial neuromuscular signaling by destabilizing the ternary SNARE complex (acts as a SNAP-25 N-terminal mimic) A randomized, placebo-controlled human study reported ~49% subjective improvement in periorbital wrinkles vs 0% for placebo over 4 weeks (small evidence base) \[PMID: 23417317\] Marketed as a topical 'Botox alternative' - reversible mechanism, not a neurotoxin, with no botulinum-type systemic risk Supplied as a raw cosmetic-compounding powder for research/formulation use (verify purity via HPLC COA) Commonly combined with related peptides (e.g., Acetyl Octapeptide-3 / Snap-8) in anti-wrinkle formulations Safety Notes Common Well tolerated in clinical cosmetic literature Mild transient erythema at high concentrations Serious No systemic adverse events at topical cosmetic doses Not for injection use ### Overview Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation. ## Chemical Information IUPAC Name Not yet available CAS Number Not yet available Molecular Formula Not yet available Molecular Mass 888.99 g/mol Amino Acid Sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 (Ac-EEMQRR-NH2); N-terminally acetylated, C-terminally amidated synthetic hexapeptide patterned after the N-terminal domain of SNAP-25 ## Dosing & Protocols ### Unlock Dosing Protocols Free account gets you: - View beginner, intermediate & advanced protocols - See weight-based dosing calculations - Access cycle length & frequency data [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Research ### Unlock Research Data Free account gets you: - Browse PubMed study summaries - See clinical trial phases & results - Access mechanism of action details [Create free account](/auth)[Sign in](/auth) 2,800+ researchers already in ## Interactions Interaction and contraindication data is being compiled for Acetyl Hexapeptide-8. Check back soon. General Safety Note Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented. Best Price $129.00 Best $/mg $0.1290 Vendors 1 Listings 1 powder [Sign in for alerts ](/auth) Form Allpowder Sort Price $/mg Vendor Vendor Product Form Qty Price $/mg Coupon ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) [Ion Peptide](/vendor/ion-peptide) [70 ](/vendor-trust-scorecard) 🇺🇸 US 🌍 International Acetyl Hexapeptide-8 Raw 1g powder 1g ● In Stock $129.00 BEST $0.129 — [Buy](https://ionpeptide.com/product/acetyl-hexapeptide-8-raw-1g/?ref=reddit15) Get Acetyl Hexapeptide-8 Price Drop Alerts Set a target price and we'll notify you when any vendor drops below it. Current lowest: $129.00 [Sign in to set alerts](/auth) ### Sign in to leave a review Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Acetyl Hexapeptide-8. [Sign in](/auth) Current low $129.00 as of Apr 22, 2026 7-day low — no 7d data yet 30-day low — no 30d data yet 30-day change — baseline building Tracking since Apr 22, 2026 · 1 data point ### Vendors Selling Acetyl Hexapeptide-8 [ ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) #### Ion Peptide 4.5 1 listing · from $129.00 ](/vendor/ion-peptide) How we score these vendors Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. [View Scorecard](/vendors/scorecard) ### Related Compounds [View All](/wiki) [ ### AHK-Cu Skin & Hair Preclinical AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). t½ Unknown (topical half-life, follicular retention not well characterized) 0 Preclinical View Profile ](/compound/ahk-cu)[ ### Melanotan 2 Skin & Hair Discontinued (early clinical) A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression.. t½ ~1–2 hours 100-1,000 mcg per injection Preclinical View Profile ](/compound/melanotan-2)[ ### Minoxidil Skin & Hair FDA-Approved Minoxidil is an FDA-approved treatment for pattern hair loss. t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically. Preclinical View Profile ](/compound/minoxidil)[ ### PDRN Skin & Hair Phase 4 PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. t½ Short (oligonucleotides degraded rapidly; tissue effects persist longer) 0 Preclinical View Profile ](/compound/pdrn)[ ### Snap-8 Skin & Hair Preclinical Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). t½ Not characterized (topical peptide) 0 Preclinical View Profile ](/compound/snap-8) [ View Full Dosage Guide → Protocols, calculator & safety for Acetyl Hexapeptide-8 ](/guides/dosage/acetyl-hexapeptide-8) ### Best Price ![Ion Peptide logo](https://ionpeptide.com/wp-content/uploads/2025/08/ion-peptide-logo-1-300x148.jpg) Ion Peptide $129.00 [Buy Now](https://ionpeptide.com/product/acetyl-hexapeptide-8-raw-1g/?ref=reddit15) 1 vendors · 1 listings ### Research Score 45 0 PubMed studies ### Quality Indicators Data Completeness 63% Description Mechanism of Action Chemical Data Dosing Protocols Safety Profile PubMed Studies Interactions Vendor Listings ### Quick Facts Half-Life Short (topical application, no systemic absorption at cosmetic doses) Molecular Weight 888.99 g/mol Administration Topical Trial Phase Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug. ### Safety Profile Common Side Effects - • Well tolerated in clinical cosmetic literature - • Mild transient erythema at high concentrations [Full Dosage Guide](/guides/dosage/acetyl-hexapeptide-8)[Calculate Your Dose](/tools/reconstitution) Research Disclaimer This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use. ## Frequently Asked Questions What is Acetyl Hexapeptide-8 used for in research? Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation. What forms does Acetyl Hexapeptide-8 come in? Acetyl Hexapeptide-8 is available in powder form. How much does Acetyl Hexapeptide-8 cost? Prices start at $129.00 across 1 verified vendor. How do I compare Acetyl Hexapeptide-8 vendors? Compare prices, payment methods, shipping, and COA scores across 1 vendor. ## Research Tools [ ### Peptide Calculator Reconstitution & syringe units ](/tools/reconstitution)[ ### Reconstitution Guide How to mix, step by step ](/guides/how-to-reconstitute-peptides)[ ### Nasal Spray Calc mL per actuation ](/tools/intranasal)[ ### Half-Life Visualizer Decay curves ](/tools/halflife) ## Related Compounds [View All](/wiki) [ ### AHK-Cu Skin & Hair Preclinical AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper). t½ Unknown (topical half-life, follicular retention not well characterized) 0 Preclinical View Profile ](/compound/ahk-cu)[ ### Melanotan 2 Skin & Hair Discontinued (early clinical) A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression.. t½ ~1–2 hours 100-1,000 mcg per injection Preclinical View Profile ](/compound/melanotan-2)[ ### Minoxidil Skin & Hair FDA-Approved Minoxidil is an FDA-approved treatment for pattern hair loss. t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically. Preclinical View Profile ](/compound/minoxidil)[ ### PDRN Skin & Hair Phase 4 PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. t½ Short (oligonucleotides degraded rapidly; tissue effects persist longer) 0 Preclinical View Profile ](/compound/pdrn)[ ### Snap-8 Skin & Hair Preclinical Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox). t½ Not characterized (topical peptide) 0 Preclinical View Profile ](/compound/snap-8) Free 2026 Peptide Cheat Sheet — 50 pages, PDF Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one. [Download Free](/guides/peptide-cheat-sheet-download?utm_source=compound-acetyl-hexapeptide-8) ### Need bloodwork before starting? Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount. [Order Bloodwork](https://anabolicinsights.ai/?ref=nwm2zjb) ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews. [support@bodyhackguide.co](mailto:support@bodyhackguide.co) [](https://discord.gg/Mhq5UdRYBA)[](https://reddit.com/r/BodyHackGuide)[](https://x.com/bodyhackguide) Explore #### Explore - [Compare prices](/compare) - [Research suppliers](/vendors) - [Deals](/deals) - [Coupons](/coupons) - [Nootropics](/nootropics) - [Brain health](/brain-health) - [Blog](/blog) - [Guides](/guides) Tools #### Tools - [Reconstitution](/tools/reconstitution) - [Dosage calculator](/tools/dosage) - [Half-life visualizer](/tools/halflife) - [COA lookup](/tools/coa) - [Cost calculator](/tools/cost-calculator) - [Stack builder](/stack-builder) - [All tools →](/tools) Trust & vendors #### Trust & vendors - [Vendor directory](/vendors) - [Trust scorecard](/vendors/scorecard) - [Get BHG verified](/vendors/get-vetted) - [Scoring methodology](/vendors/methodology) - [Peptide cheatsheet](/guides/peptide-cheat-sheet-download) Company #### Company - [About](/about) - [Affiliate disclosure](/affiliate-disclosure) - [Editorial standards](/editorial-standards) - [Creators](/creators) - [Coaches](/coaches) - [Privacy](/privacy) - [Terms](/terms) - [Full site directory →](/site-directory) **Ownership & Affiliate Disclosure:** BodyHackGuide and BHG Labs share common ownership. We rank every vendor on the same public, reproducible [methodology](/vendors/methodology), and we earn a commission from purchases made through our links at no extra cost to you. Full details in our [affiliate disclosure](/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell, distribute, or promote any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. · [Terms](/terms) · [Privacy](/privacy) hi 👋