--- title: "Uridine Monophosphate vs PE-22-28: Compared (2026)" url: https://www.bodyhackguide.co/compare/uridine-monophosphate-vs-pe-22-28 description: "Compare Uridine Monophosphate vs PE-22-28 side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Uridine Monophosphate (UMP) vs PE-22-28 Side-by-side comparison of Uridine Monophosphate (UMP) and PE-22-28: mechanism, half-life, dose range, safety profile, and vendor pricing. Uridine Monophosphate (UMP): no price on file PE-22-28 from $49.99 ## Price snapshot ### Uridine Monophosphate (UMP) Current low — 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### PE-22-28 Current low $49.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Uridine Monophosphate (UMP) Uridine monophosphate (UMP, also written 5'-UMP or uridine-5'-monophosphate) is the nucleotide form of uridine, consisting of the pyrimidine base uracil linked to a ribose sugar phosphorylated at the 5' position. It is… No vendor price on file. Full Uridine Monophosphate (UMP) profile (https://www.bodyhackguide.co/compound/uridine-monophosphate) ## PE-22-28 PE-22-28 is a synthetic seven-amino-acid peptide (sequence PAGASRLLLLTGEIDLP derivative, commonly truncated to PE-22-28 as shorthand for "position 22-28" within the parent humanin-family sequence) that was designed as an… **Lowest listed price:** $49.99 across 1 listing Full PE-22-28 profile (https://www.bodyhackguide.co/compound/pe-22-28) ## Side-by-side comparison | Attribute | Uridine Monophosphate (UMP) | PE-22-28 | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Clinical (human studies of uridine alone and inside the Souvenaid drink; the prodrug uridine triacetate is FDA-approved) | Preclinical | | Mechanism of Action | Uridine monophosphate's mechanism of action as a nootropic is grounded in its role as a precursor for membrane phospholipid synthesis via the Kennedy pathway, with additional proposed effects on purinergic signalling, dopaminergic function, and synaptic… | PE-22-28 is a synthetic 7-amino-acid peptide (sequence GVSWGLR) and a shortened analog of spadin. Its proposed mechanism is inhibition of the TREK-1 (TWIK-related K+) channel, a two-pore-domain potassium channel (K2P2.1 / KCNK2) implicated in mood regulation.… | | Half-Life | — | Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. | | Typical Dose Range | — | 250-2000 mcg subcutaneous per dose (empirical research-chemical community range; no clinically validated human dose exists; effective preclinical rodent doses were far lower, ~3 mcg/kg). | | Dosing Frequency | — | Once daily or every other day (research-chemical community protocols; no validated clinical dosing schedule). | | Administration | — | — | | Side Effects | Uridine monophosphate has one of the most favourable safety profiles of any supplement in the nootropic space. It is a naturally occurring nutrient, present in human breast milk, liver, fish, and many other foods. Clinical trials with daily doses up to 2 grams… | No human side-effect data exist for PE-22-28 because it has never been tested in people. What can be said comes from rodent studies of PE-22-28, spadin and their analogs, plus general considerations for injected research peptides. In the preclinical work, the… | | Molecular Weight | 324.18 g/mol | 773.9 g/mol | | Common Vial Sizes | — | — | ## Price History 2 data points ### Uridine Monophosphate (UMP): potential benefits - D2/D3 receptor upregulation - Mood stabilization - Memory improvement - Synaptic plasticity - Neuronal membrane support - Long-term cognitive enhancement ### PE-22-28: potential benefits - Antidepressant-like effects in rodent models of depression (preclinical only) - Potent, selective inhibition of the TREK-1 (K2P2.1) potassium channel (IC50 ~0.12 nM) - Rapid-onset (~4-day) antidepressant profile in animals, unlike the multi-week lag of SSRIs - Increased hippocampal neurogenesis in mice - Increased cortical synaptogenesis (PSD-95) and BDNF expression in preclinical studies - No human-validated benefits; not approved for any use (research use only) ## Frequently asked ### What's the difference between Uridine Monophosphate (UMP) and PE-22-28? Uridine Monophosphate (UMP) is a nootropics that uridine monophosphate's mechanism of action as a nootropic is grounded in its role as a precursor for membrane phospholipid synthesis via the kennedy pathway, with additional…. PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range. ### Which has the longer half-life, Uridine Monophosphate (UMP) or PE-22-28? Uridine Monophosphate (UMP) has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Can you stack Uridine Monophosphate (UMP) and PE-22-28? Stacking depends on mechanism overlap, safety profile, and goals. Uridine Monophosphate (UMP) and PE-22-28 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Uridine Monophosphate (UMP) prices: https://www.bodyhackguide.co/compound/uridine-monophosphate?tab=prices PE-22-28 prices: https://www.bodyhackguide.co/compound/pe-22-28?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Uridine Monophosphate (UMP) or PE-22-28 Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. 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PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, Uridine Monophosphate (UMP) or PE-22-28?", "acceptedAnswer": { "@type": "Answer", "text": "Uridine Monophosphate (UMP) has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. 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