--- title: "TUDCA vs MOTS-c: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/tudca-vs-mots-c description: "Compare TUDCA vs MOTS-c side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices. TUDCA from $79.99." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # TUDCA vs MOTS-c Side-by-side comparison of TUDCA and MOTS-c: mechanism, half-life, dose range, safety profile, and vendor pricing. TUDCA from $79.99 MOTS-c from $44.99 ## Price snapshot ### TUDCA Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### MOTS-c Current low $44.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## TUDCA TUDCA (tauroursodeoxycholic acid) is a hydrophilic bile acid formed by taurine conjugation of ursodeoxycholic acid (UDCA, the active ingredient in the widely-prescribed cholestasis medication Ursodiol). TUDCA occurs… **Lowest listed price:** $79.99 across 1 listing Full TUDCA profile (https://www.bodyhackguide.co/compound/tudca) ## MOTS-c MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It… **Lowest listed price:** $44.99 across 9 listings Full MOTS-c profile (https://www.bodyhackguide.co/compound/mots-c) ## Side-by-side comparison | Attribute | TUDCA | MOTS-c | | --- | --- | --- | | Category | Liver Support | Longevity & Cellular Health | | Research Stage | Preclinical | Preclinical | | Mechanism of Action | TUDCA's mechanism of action operates through several distinct but overlapping pathways, making it unusual among bile acid therapeutics in having multiple pharmacologically meaningful modes of activity beyond simple bile-acid replacement. Pathway 1: Bile acid… | A New Class of Signaling Molecule MOTS-c belongs to the mitochondrial-derived peptides (MDPs) - a class of small peptides encoded within mitochondrial DNA open reading frames that were historically thought to encode only ribosomal RNAs. The known MDPs include:… | | Half-Life | — | ~4–6 hours | | Typical Dose Range | — | 5,000–10,000 mcg (5–10 mg) per injection | | Dosing Frequency | — | 2-3 times per week | | Administration | — | Subcutaneous, Intramuscular | | Side Effects | TUDCA has an exceptionally favorable safety profile with decades of clinical use at the traditional cholestasis doses and accumulating safety data at the higher doses used in ALS trials. Common side effects (5-15% at typical doses 250-1,000 mg/day): - Mild… | Reported Effects (limited human data) - Injection site reactions — Mild erythema, transient itching at SC injection site. Site rotation minimizes. Probably the single most reported issue. - Transient fatigue — Some users report mild fatigue in the first week… | | Molecular Weight | — | 2174 Da | | Common Vial Sizes | — | 5mg, 10mg | ## Price tracking Tracking TUDCA prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price History 5 data points - OF - BM - Half Nattys - Ion Peptide - Disguised Alpha - BHG Labs ### TUDCA: potential benefits - No structured benefit list published. ### MOTS-c: potential benefits - Insulin sensitivity - Exercise mimicry - Metabolic health - Anti-aging - Fat oxidation - Longevity ## Frequently asked ### What's the difference between TUDCA and MOTS-c? TUDCA is a liver support that tudca's mechanism of action operates through several distinct but overlapping pathways, making it unusual among bile acid therapeutics in having multiple pharmacologically…. MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. The two differ in mechanism, half-life (not reported vs ~4–6 hours), and typical dose range. ### Which has the longer half-life, TUDCA or MOTS-c? TUDCA has a half-life of not reported. MOTS-c has a half-life of ~4–6 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, TUDCA or MOTS-c? Lowest listed price on BodyHackGuide: TUDCA from $79.99, MOTS-c from $44.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack TUDCA and MOTS-c? Stacking depends on mechanism overlap, safety profile, and goals. TUDCA and MOTS-c should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. TUDCA prices: https://www.bodyhackguide.co/compound/tudca?tab=prices MOTS-c prices: https://www.bodyhackguide.co/compound/mots-c?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy TUDCA or MOTS-c Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons MOTS C vs SS-31: https://www.bodyhackguide.co/compare/mots-c-vs-ss-31 Methylene Blue vs MOTS C: https://www.bodyhackguide.co/compare/methylene-blue-vs-mots-c MOTS C vs NMN: https://www.bodyhackguide.co/compare/mots-c-vs-nmn **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). 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