--- title: "SS-31 vs Caffeine: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/ss-31-vs-caffeine description: "Compare SS-31 vs Caffeine side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices. SS-31 from $72.00." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # SS-31 vs Caffeine Side-by-side comparison of SS-31 and Caffeine: mechanism, half-life, dose range, safety profile, and vendor pricing. SS-31 from $72.00 Caffeine: no price on file ## Price snapshot ### SS-31 Current low $72.00 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### Caffeine Current low — 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## SS-31 Featured SS-31 (elamipretide; MTP-131; formerly Bendavia; chemical sequence D-Arg-Dmt-Lys-Phe-NH2 with dimethyltyrosine at position 2) is a first-in-class aromatic-cationic tetrapeptide designed to selectively target the inner… **Lowest listed price:** $72.00 across 4 listings Full SS-31 profile (https://www.bodyhackguide.co/compound/ss-31) ## Caffeine Caffeine (1,3,7-trimethylxanthine) is a natural methylxanthine alkaloid found in the seeds, fruits, leaves, and bark of over 60 plant species — most notably Coffea (coffee), Camellia sinensis (tea), Theobroma cacao… No vendor price on file. Full Caffeine profile (https://www.bodyhackguide.co/compound/caffeine) ## Side-by-side comparison | Attribute | SS-31 | Caffeine | | --- | --- | --- | | Category | Mitochondrial Peptides | Nootropics | | Research Stage | Clinical/Approved | Approved (prescription) | | Mechanism of Action | SS-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high concentration of cardiolipin, a signature mitochondrial anionic phospholipid - to… | Caffeine's mechanism is anchored in adenosine receptor antagonism but extends to several secondary pharmacological actions that together produce its characteristic profile of alertness, cognitive enhancement, cardiovascular effects, and metabolic activation.… | | Half-Life | ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding | — | | Typical Dose Range | 20-60 mg | — | | Dosing Frequency | Once daily subcutaneous (some protocols use 5-6 days per week) | — | | Administration | — | — | | Side Effects | SS-31 (elamipretide) has been generally well-tolerated across clinical trials spanning over a decade of human exposure, with adverse event profiles dominated by injection site reactions rather than systemic toxicity. This favorable safety profile reflects both… | Caffeine's side effects range from minor acute effects to serious toxicity at extreme doses, with substantial individual variability reflecting genetic (CYP1A2), physiological, and psychological factors. Common acute side effects (dose-related): At typical… | | Molecular Weight | 639.8 g/mol | — | | Common Vial Sizes | — | — | ## Price History 2 data points - Ion Peptide - BHG Labs ## Frequently asked ### What's the difference between SS-31 and Caffeine? SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. Caffeine is a nootropics that caffeine's mechanism is anchored in adenosine receptor antagonism but extends to several secondary pharmacological actions that together produce its characteristic profile of…. The two differ in mechanism, half-life (~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding vs not reported), and typical dose range. ### Which has the longer half-life, SS-31 or Caffeine? SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. Caffeine has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Can you stack SS-31 and Caffeine? Stacking depends on mechanism overlap, safety profile, and goals. SS-31 and Caffeine should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. SS-31 prices: https://www.bodyhackguide.co/compound/ss-31?tab=prices Caffeine prices: https://www.bodyhackguide.co/compound/caffeine?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy SS-31 or Caffeine Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons MOTS C vs SS-31: https://www.bodyhackguide.co/compare/mots-c-vs-ss-31 Theacrine vs Caffeine: https://www.bodyhackguide.co/compare/theacrine-vs-caffeine **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "SS-31 vs Caffeine" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "SS-31 vs Caffeine: Side-by-Side Comparison (2026)", "description": "Compare SS-31 vs Caffeine side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices. 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