--- title: "Sermorelin vs Ipamorelin: Side-by-Side Comparison (2026)" description: "Compare Sermorelin vs Ipamorelin — mechanism, half-life, dose range, side effects, and live vendor pricing. Sermorelin from $24.99. Ipamorelin from $24.99." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Sermorelin vs Ipamorelin" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "Sermorelin vs Ipamorelin: Side-by-Side Comparison (2026)", "description": "Compare Sermorelin vs Ipamorelin — mechanism, half-life, dose range, side effects, and live vendor pricing. Sermorelin from $24.99. Ipamorelin from $24.99. Side-by-side data from BodyHackGuide — we earn a commission on some vendor links.", "url": "https://www.bodyhackguide.co/compare/sermorelin-vs-ipamorelin", "dateModified": "2026-09-08", "isPartOf": { "@type": "WebSite", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainEntity": { "@type": "ItemList", "itemListElement": [ { "@type": "ListItem", "position": 1, "item": { "@type": "Product", "name": "Sermorelin", "description": "Sermorelin acetate is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of human growth hormone-releasing hormone (GHRH 1-29). It was one of the first GHRH analogs to achieve FDA approval — Geref received pediatric approval in 1997 for evaluating and…", "url": "https://www.bodyhackguide.co/compound/sermorelin", "category": "Growth Hormone / IGF-1 Axis", "offers": { "@type": "AggregateOffer", "lowPrice": "24.99", "priceCurrency": "USD", "offerCount": 8 } } }, { "@type": "ListItem", "position": 2, "item": { "@type": "Product", "name": "Ipamorelin", "description": "Ipamorelin is a selective pentapeptide ghrelin receptor (GHS-R1a) agonist — one of the most studied growth hormone secretagogues (GHS) in the biohacking community and the modern companion to CJC-1295 / MOD-GRF 1-29. Its five-amino-acid sequence (Aib-His-D-2Nal-D-Phe-Lys-NH₂) was discovered by Novo…", "url": "https://www.bodyhackguide.co/compound/ipamorelin", "category": "Growth Hormone / IGF-1 Axis", "offers": { "@type": "AggregateOffer", "lowPrice": "24.99", "priceCurrency": "USD", "offerCount": 5 } } } ] } }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 124+ compound profiles, interactive dosing calculators, real-time vendor pricing, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. BodyHackGuide and BHG Labs share common ownership, and we earn a commission on purchases through our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://x.com/bodyhackguide", "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What's the difference between Sermorelin and Ipamorelin?", "acceptedAnswer": { "@type": "Answer", "text": "Sermorelin is a growth hormone / igf-1 axis that ghrh receptor pharmacology sermorelin is a truncated analog - the first 29 amino acids - of the 44-amino-acid native ghrh produced by the arcuate nucleus of the hypothalamus. the…. Ipamorelin is a growth hormone / igf-1 axis that ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (ghs-r1a), the same receptor activated by endogenous ghrelin - the \"hunger hormone\" secreted…. The two differ in mechanism, half-life (~10-20 minutes (plasma; native GHRH 7 minutes) vs ~2 hours (plasma)), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, Sermorelin or Ipamorelin?", "acceptedAnswer": { "@type": "Answer", "text": "Sermorelin has a half-life of ~10-20 minutes (plasma; native GHRH 7 minutes). Ipamorelin has a half-life of ~2 hours (plasma). Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, Sermorelin or Ipamorelin?", "acceptedAnswer": { "@type": "Answer", "text": "Current lowest live price on BodyHackGuide: Sermorelin from $24.99, Ipamorelin from $24.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack Sermorelin and Ipamorelin?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. Sermorelin and Ipamorelin should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompare%2Fsermorelin-vs-ipamorelin) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compare](/compare) 3. Sermorelin vs Ipamorelin # Sermorelin vs Ipamorelin Side-by-side comparison of Sermorelin and Ipamorelin: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land. Sermorelin from $24.99 Ipamorelin from $24.99 ## Live price snapshot ### Sermorelin Current low $49.99 as of Sep 5, 2026 7-day low $49.99 30-day low $49.99 30-day change — baseline building ### Ipamorelin Current low $59.99 as of Sep 5, 2026 7-day low $59.99 30-day low $59.99 30-day change — baseline building ## Sermorelin Sermorelin acetate is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of human growth hormone-releasing hormone (GHRH 1-29). It was one of the first GHRH analogs to achieve… **Live lowest price:** $24.99 across 8 vendors [Full Sermorelin profile](/compound/sermorelin) ## Ipamorelin Ipamorelin is a selective pentapeptide ghrelin receptor (GHS-R1a) agonist — one of the most studied growth hormone secretagogues (GHS) in the biohacking community and the modern companion to CJC-1295 / MOD-GRF 1-29. Its… **Live lowest price:** $24.99 across 5 vendors [Full Ipamorelin profile](/compound/ipamorelin) ## Side-by-side comparison Attribute Sermorelin Ipamorelin Category Growth Hormone / IGF-1 Axis Growth Hormone / IGF-1 Axis Research Stage FDA-Approved (Geref, discontinued 2008) Phase 2 Mechanism of Action GHRH Receptor Pharmacology Sermorelin is a truncated analog - the first 29 amino acids - of the 44-amino-acid native GHRH produced by the arcuate nucleus of the hypothalamus. The 1-29 fragment retains essentially the full growth-hormone-releasing activity of… Ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (GHS-R1a), the same receptor activated by endogenous ghrelin - the "hunger hormone" secreted primarily by P/D1 cells in the gastric fundus. The distinguishing feature of… Half-Life ~10-20 minutes (plasma; native GHRH 7 minutes) ~2 hours (plasma) Typical Dose Range — 100-300 mcg subcutaneous 1-3x daily (most commonly 200-300 mcg pre-bedtime); often combined with CJC-1295 without DAC at 100-300 mcg Dosing Frequency — 1–3 times daily; most commonly once at bedtime Administration — subcutaneous, intravenous (clinical only) Side Effects Common Effects - Injection site reactions — The most frequently reported issue. Mild erythema, transient itching, or a small wheal at the subcutaneous injection site. Usually self-resolves within 30-60 minutes and rarely requires intervention beyond site… Ipamorelin has the cleanest side-effect profile of any ghrelin-receptor agonist, which is why it dominates modern biohacking protocols. The profile is driven by (a) selective GHS-R1a agonism without cross-receptor activity, and (b) acute GH elevation (the same… Molecular Weight 3357.9 g/mol 711.9 Da Common Vial Sizes — 2mg, 5mg ## Price History 5 data points - BM - Unknown - VANDL Labs - Ion Peptide - Disguised Alpha ## Price History 4 data points - OF - VANDL Labs - Ion Peptide - Disguised Alpha ### Sermorelin — potential benefits - Natural GH pulse stimulation - Improved sleep quality - Enhanced recovery and body composition - Anti-aging effects - Better skin elasticity - Increased lean muscle mass ### Ipamorelin — potential benefits - Increased GH pulse amplitude (selective somatotroph activation) - Elevated IGF-1 (~30-80% over baseline) with consistent dosing - Improved slow-wave sleep architecture - No cortisol / prolactin / ACTH elevation (unique among GHS peptides) - Accelerated connective tissue and wound repair - Modest lean body mass gain + fat loss in hypogonadal adults - Enhanced recovery between training sessions - Synergistic effect with CJC-1295 / MOD-GRF 1-29 ## Frequently asked ### What's the difference between Sermorelin and Ipamorelin? Sermorelin is a growth hormone / igf-1 axis that ghrh receptor pharmacology sermorelin is a truncated analog - the first 29 amino acids - of the 44-amino-acid native ghrh produced by the arcuate nucleus of the hypothalamus. the…. Ipamorelin is a growth hormone / igf-1 axis that ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (ghs-r1a), the same receptor activated by endogenous ghrelin - the "hunger hormone" secreted…. The two differ in mechanism, half-life (~10-20 minutes (plasma; native GHRH 7 minutes) vs ~2 hours (plasma)), and typical dose range. ### Which has the longer half-life, Sermorelin or Ipamorelin? Sermorelin has a half-life of ~10-20 minutes (plasma; native GHRH 7 minutes). Ipamorelin has a half-life of ~2 hours (plasma). Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Sermorelin or Ipamorelin? Current lowest live price on BodyHackGuide: Sermorelin from $24.99, Ipamorelin from $24.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers. ### Can you stack Sermorelin and Ipamorelin? Stacking depends on mechanism overlap, safety profile, and goals. Sermorelin and Ipamorelin should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Live listings from the vendors we track, refreshed continuously. [Sermorelin prices](/compound/sermorelin?tab=prices) [Ipamorelin prices](/compound/ipamorelin?tab=prices) [Compare all compounds](/compare) ### Before you buy Sermorelin or Ipamorelin Check the vendor trust score. Every supplier we track is rated 0–100 on COA verification, payment transparency, shipping, reviews, and listings — one published, reproducible methodology, applied to every vendor including BHG Labs, which shares our ownership. [View Vendor Scorecard](/vendors/scorecard) ## Related comparisons [Ipamorelin vs MK-677](/compare/ipamorelin-vs-mk-677)[CJC-1295 vs Ipamorelin](/compare/cjc-1295-vs-ipamorelin)[Tesamorelin vs Sermorelin](/compare/tesamorelin-vs-sermorelin)[Hexarelin vs Ipamorelin](/compare/hexarelin-vs-ipamorelin)[IGF-1-LR3 vs Ipamorelin](/compare/igf-1-lr3-vs-ipamorelin)[GHRP-2 vs Ipamorelin](/compare/ghrp-2-vs-ipamorelin)[CJC-1295 vs Sermorelin](/compare/cjc-1295-vs-sermorelin)[Tesamorelin vs CJC-1295](/compare/tesamorelin-vs-cjc-1295) **Research use only.** BodyHackGuide is a research and price-comparison reference. BodyHackGuide and BHG Labs share common ownership. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See [editorial standards](/editorial-standards) and [affiliate disclosure](/affiliate-disclosure). ![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp) ### BodyHackGuide Your biohacking research hub — compound pricing, brain health protocols, dosing tools, and vendor reviews. [support@bodyhackguide.co](mailto:support@bodyhackguide.co) [](https://discord.gg/Mhq5UdRYBA)[](https://reddit.com/r/BodyHackGuide)[](https://x.com/bodyhackguide) Explore #### Explore - [Compare prices](/compare) - [Research suppliers](/vendors) - [Deals](/deals) - [Coupons](/coupons) - [Nootropics](/nootropics) - [Brain health](/brain-health) - [Blog](/blog) - [Guides](/guides) Tools #### Tools - [Reconstitution](/tools/reconstitution) - [Dosage calculator](/tools/dosage) - [Half-life visualizer](/tools/halflife) - [COA lookup](/tools/coa) - [Cost calculator](/tools/cost-calculator) - [Stack builder](/stack-builder) - [All tools →](/tools) Trust & vendors #### Trust & vendors - [Vendor directory](/vendors) - [Trust scorecard](/vendors/scorecard) - [Get BHG verified](/vendors/get-vetted) - [Scoring methodology](/vendors/methodology) - [Peptide cheatsheet](/guides/peptide-cheat-sheet-download) Company #### Company - [About](/about) - [Affiliate disclosure](/affiliate-disclosure) - [Editorial standards](/editorial-standards) - [Creators](/creators) - [Coaches](/coaches) - [Privacy](/privacy) - [Terms](/terms) - [Full site directory →](/site-directory) **Ownership & Affiliate Disclosure:** BodyHackGuide and BHG Labs share common ownership. We rank every vendor on the same public, reproducible [methodology](/vendors/methodology), and we earn a commission from purchases made through our links at no extra cost to you. Full details in our [affiliate disclosure](/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell, distribute, or promote any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. · [Terms](/terms) · [Privacy](/privacy) [Shop BHG Labs · 20% off with BHG20](https://bhglabs.co/shop/?utm_source=reddit&utm_medium=paid&utm_campaign=bhg20_bridge&utm_content=sticky_mobile_bar&ref=zmgqyxku&coupon=BHG20) hi 👋