--- title: "Selank vs Phenibut: Side-by-Side Comparison (2026)" description: "Compare Selank vs Phenibut — mechanism, half-life, dose range, side effects, and live vendor pricing. Selank from $25.00. Phenibut from $49.99. Side-by-side" lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Selank vs Phenibut" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "Selank vs Phenibut: Side-by-Side Comparison (2026)", "description": "Compare Selank vs Phenibut — mechanism, half-life, dose range, side effects, and live vendor pricing. Selank from $25.00. Phenibut from $49.99. 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Phenibut is a nootropics that phenibut's pharmacology is dominated by activity at the gaba-b receptor, with secondary effects at gaba-a receptors and voltage-gated calcium channels. understanding these three…. The two differ in mechanism, half-life (~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) vs 5-8 hours (plasma); central CNS effect 10-16 hours), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, Selank or Phenibut?", "acceptedAnswer": { "@type": "Answer", "text": "Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Phenibut has a half-life of 5-8 hours (plasma); central CNS effect 10-16 hours. 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Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompare%2Fselank-vs-phenibut) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compare](/compare) 3. Selank vs Phenibut # Selank vs Phenibut Side-by-side comparison of Selank and Phenibut: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land. Selank from $25.00 Phenibut from $49.99 ## Live price snapshot ### Selank Current low $44.99 as of Sep 5, 2026 7-day low $44.99 30-day low $44.99 30-day change — baseline building ### Phenibut Current low $49.99 as of Sep 5, 2026 7-day low $49.99 30-day low $49.99 30-day change — baseline building ## Selank Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin… **Live lowest price:** $25.00 across 7 vendors [Full Selank profile](/compound/selank) ## Phenibut Phenibut is the common Western name for β-phenyl-γ-aminobutyric acid (beta-phenyl-GABA; Russian trade names Phenibut/Фенибут, Noofen, Anvifen), a Soviet-era anxiolytic and nootropic developed in the 1960s at the Herzen… **Live lowest price:** $49.99 across 1 vendor [Full Phenibut profile](/compound/phenibut) ## Side-by-side comparison Attribute Selank Phenibut Category Nootropics Nootropics Research Stage Approved (Russia, as anxiolytic and nootropic medication) Prescription Medicine (Russia/CIS) / Unregulated Elsewhere Mechanism of Action Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… Phenibut's pharmacology is dominated by activity at the GABA-B receptor, with secondary effects at GABA-A receptors and voltage-gated calcium channels. Understanding these three components is essential to understanding both its therapeutic effects and its… Half-Life ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) 5-8 hours (plasma); central CNS effect 10-16 hours Typical Dose Range 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days — Dosing Frequency Intranasal 1–3 times daily — Administration Intranasal Oral Side Effects Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… Phenibut's side effects fall into three categories: acute-dose effects (largely dose-dependent sedation and impairment), withdrawal effects (physiologically similar to benzodiazepine/alcohol withdrawal), and interactions with other CNS depressants (additive… Molecular Weight 751.9 Da 179.22 g/mol (free base); 215.68 g/mol (HCl salt) Common Vial Sizes 5mg, 10mg — ## Price History 8 data points - OF - Unknown - VANDL Labs - Unknown - Ion Peptide - BHG Labs - Disguised Alpha ## Price History 2 data points - Unknown - Disguised Alpha ### Selank — potential benefits - Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096) - Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741) - Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961) - Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804) - Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852) - Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation - Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use ### Phenibut — potential benefits - No structured benefit list published. ## Frequently asked ### What's the difference between Selank and Phenibut? Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. Phenibut is a nootropics that phenibut's pharmacology is dominated by activity at the gaba-b receptor, with secondary effects at gaba-a receptors and voltage-gated calcium channels. understanding these three…. The two differ in mechanism, half-life (~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) vs 5-8 hours (plasma); central CNS effect 10-16 hours), and typical dose range. ### Which has the longer half-life, Selank or Phenibut? Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Phenibut has a half-life of 5-8 hours (plasma); central CNS effect 10-16 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Selank or Phenibut? Current lowest live price on BodyHackGuide: Selank from $25.00, Phenibut from $49.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers. ### Can you stack Selank and Phenibut? Stacking depends on mechanism overlap, safety profile, and goals. Selank and Phenibut should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Live listings from the vendors we track, refreshed continuously. 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