--- title: "Selank vs Dihexa: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/selank-vs-dihexa description: "Compare Selank vs Dihexa side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices. Selank from $25.00." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Selank vs Dihexa Side-by-side comparison of Selank and Dihexa: mechanism, half-life, dose range, safety profile, and vendor pricing. Selank from $25.00 Dihexa from $79.99 ## Price snapshot ### Selank Current low $25.00 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### Dihexa Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Selank Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin… **Lowest listed price:** $25.00 across 6 listings Full Selank profile (https://www.bodyhackguide.co/compound/selank) ## Dihexa Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models… **Lowest listed price:** $79.99 across 3 listings Full Dihexa profile (https://www.bodyhackguide.co/compound/dihexa) ## Side-by-side comparison | Attribute | Selank | Dihexa | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Approved (Russia, as anxiolytic and nootropic medication) | Preclinical | | Mechanism of Action | Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… | Dihexa is a small-molecule analog derived from angiotensin IV (AngIV). It retains the Tyr-Ile core of Nle1-AngIV, with an N-terminal hexanoic acid cap and a C-terminal 6-aminohexanoic amide that give it metabolic stability and blood-brain-barrier penetration.… | | Half-Life | ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) | Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. | | Typical Dose Range | 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days | 5 to 40 mg oral per day (anecdotal range; no established human dose) | | Dosing Frequency | Intranasal 1–3 times daily | Once daily (oral), typically in the morning | | Administration | Intranasal | Oral, Intranasal, Subcutaneous | | Side Effects | Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… | No controlled human safety data. Anecdotal user reports include headache, fatigue, irritability or anxiety, insomnia, and vivid dreams, usually at higher doses. The most serious concern is theoretical rather than reported: because dihexa acts on the HGF/c-Met… | | Molecular Weight | 751.9 Da | 504.7 g/mol | | Common Vial Sizes | 5mg, 10mg | 50mg, 100mg | ## Price History 5 data points - OF - Half Nattys - Ion Peptide - BHG Labs ## Price History 2 data points ### Selank: potential benefits - Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096) - Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741) - Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961) - Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804) - Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852) - Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation - Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use ### Dihexa: potential benefits - Synaptogenesis: formation of new dendritic spines and functional synapses (preclinical) - Memory and spatial-learning support in rodent models - Potential research application in Alzheimer's and other neurodegenerative disease models - HGF/c-Met and PI3K/Akt-linked neuroplasticity (mechanism proposed; key paper retracted) ## Frequently asked ### What's the difference between Selank and Dihexa? Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. Dihexa is a nootropics that dihexa is a small-molecule analog derived from angiotensin iv (angiv). it retains the tyr-ile core of nle1-angiv, with an n-terminal hexanoic acid cap and a c-terminal…. The two differ in mechanism, half-life (~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) vs Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.), and typical dose range. ### Which has the longer half-life, Selank or Dihexa? Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Dihexa has a half-life of Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Selank or Dihexa? Lowest listed price on BodyHackGuide: Selank from $25.00, Dihexa from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack Selank and Dihexa? Stacking depends on mechanism overlap, safety profile, and goals. Selank and Dihexa should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Selank prices: https://www.bodyhackguide.co/compound/selank?tab=prices Dihexa prices: https://www.bodyhackguide.co/compound/dihexa?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Selank or Dihexa Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Selank vs Semax: https://www.bodyhackguide.co/compare/selank-vs-semax Selank vs Phenibut: https://www.bodyhackguide.co/compare/selank-vs-phenibut Dihexa vs Noopept: https://www.bodyhackguide.co/compare/dihexa-vs-noopept **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. 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