--- title: "Sabroxy vs PE-22-28: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/sabroxy-vs-pe-22-28 description: "Compare Sabroxy vs PE-22-28 side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Sabroxy (Oroxylin A) vs PE-22-28 Side-by-side comparison of Sabroxy (Oroxylin A) and PE-22-28: mechanism, half-life, dose range, safety profile, and vendor pricing. Sabroxy (Oroxylin A): no price on file PE-22-28 from $54.99 ## Price snapshot ### Sabroxy (Oroxylin A) Current low — 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### PE-22-28 Current low $54.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Sabroxy (Oroxylin A) Sabroxy is a standardized Oroxylum indicum (Indian trumpet tree) bark extract - typically 10% oroxylin A - sold as a nootropic supplement ingredient. Preclinical work points to dopaminergic (dopamine-reuptake-inhibiting)… No vendor price on file. Full Sabroxy (Oroxylin A) profile (https://www.bodyhackguide.co/compound/sabroxy) ## PE-22-28 PE-22-28 is a synthetic seven-amino-acid peptide (sequence PAGASRLLLLTGEIDLP derivative, commonly truncated to PE-22-28 as shorthand for "position 22-28" within the parent humanin-family sequence) that was designed as an… **Lowest listed price:** $54.99 across 1 listing Full PE-22-28 profile (https://www.bodyhackguide.co/compound/pe-22-28) ## Side-by-side comparison | Attribute | Sabroxy (Oroxylin A) | PE-22-28 | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Preclinical, with one supporting human RCT | Preclinical | | Mechanism of Action | Sabroxy is a standardized whole-plant extract of Oroxylum indicum (Indian trumpet tree) bark, typically standardized to 10% oroxylin A, and also containing related flavones such as baicalein and chrysin. Because it is a multi-constituent botanical rather than… | PE-22-28 is a synthetic 7-amino-acid peptide (sequence GVSWGLR) and a shortened analog of spadin. Its proposed mechanism is inhibition of the TREK-1 (TWIK-related K+) channel, a two-pore-domain potassium channel (K2P2.1 / KCNK2) implicated in mood regulation.… | | Half-Life | — | Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. | | Typical Dose Range | 500-1,000 mg | 250-2000 mcg subcutaneous per dose (empirical research-chemical community range; no clinically validated human dose exists; effective preclinical rodent doses were far lower, ~3 mcg/kg). | | Dosing Frequency | Once to twice daily (500 mg per dose) | Once daily or every other day (research-chemical community protocols; no validated clinical dosing schedule). | | Administration | — | — | | Side Effects | In the 12-week human trial the extract was well tolerated; the only notable adverse effects versus placebo were a slightly higher rate of mild digestive complaints and headaches [PMID:34531736]. Because of its stimulant-like, dopaminergic and wake-promoting… | No human side-effect data exist for PE-22-28 because it has never been tested in people. What can be said comes from rodent studies of PE-22-28, spadin and their analogs, plus general considerations for injected research peptides. In the preclinical work, the… | | Molecular Weight | — | 773.9 g/mol | | Common Vial Sizes | — | — | ## Price tracking Tracking PE-22-28 prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ### Sabroxy (Oroxylin A): potential benefits - Episodic memory: in the one human trial, a standardized Oroxylum indicum extract improved episodic memory and immediate word recall versus placebo [PMID:34531736]. - Working memory and learning speed: the same trial reported gains in numeric working memory and a faster rate of learning on a location-learning task [PMID:34531736]. - Focus and attention (preclinical): dopaminergic, stimulant-like activity reduced inattention and impulsivity in an ADHD rat model [PMID:23371806]. - Neuroprotection and BDNF (preclinical): rodent studies show increased BDNF/CREB signaling, less neuroinflammation, and enhanced hippocampal neurogenesis [PMID:17174385][PMID:41330961]. - Antioxidant and mitochondrial support (preclinical): the extract lowered oxidative stress and restored mitochondrial function in mice [PMID:34081735]. ### PE-22-28: potential benefits - Antidepressant-like effects in rodent models of depression (preclinical only) - Potent, selective inhibition of the TREK-1 (K2P2.1) potassium channel (IC50 ~0.12 nM) - Rapid-onset (~4-day) antidepressant profile in animals, unlike the multi-week lag of SSRIs - Increased hippocampal neurogenesis in mice - Increased cortical synaptogenesis (PSD-95) and BDNF expression in preclinical studies - No human-validated benefits; not approved for any use (research use only) ## Frequently asked ### What's the difference between Sabroxy (Oroxylin A) and PE-22-28? Sabroxy (Oroxylin A) is a nootropics that sabroxy is a standardized whole-plant extract of oroxylum indicum (indian trumpet tree) bark, typically standardized to 10% oroxylin a, and also containing related flavones such as…. PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range. ### Which has the longer half-life, Sabroxy (Oroxylin A) or PE-22-28? Sabroxy (Oroxylin A) has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Can you stack Sabroxy (Oroxylin A) and PE-22-28? Stacking depends on mechanism overlap, safety profile, and goals. Sabroxy (Oroxylin A) and PE-22-28 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Sabroxy (Oroxylin A) prices: https://www.bodyhackguide.co/compound/sabroxy?tab=prices PE-22-28 prices: https://www.bodyhackguide.co/compound/pe-22-28?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Sabroxy (Oroxylin A) or PE-22-28 Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). 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