--- title: "PT-141 vs N-Acetyl-Selank: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/pt-141-vs-n-acetyl-selank description: "Compare PT-141 vs N-Acetyl-Selank side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # PT-141 (Bremelanotide) vs N-Acetyl-Selank Side-by-side comparison of PT-141 (Bremelanotide) and N-Acetyl-Selank: mechanism, half-life, dose range, safety profile, and vendor pricing. PT-141 (Bremelanotide) from $34.99 N-Acetyl-Selank from $79.99 ## Price snapshot ### PT-141 (Bremelanotide) Current low $34.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### N-Acetyl-Selank Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## PT-141 (Bremelanotide) PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain — not peripherally on genital tissue — to improve sexual desire, arousal, and responsiveness. It is… **Lowest listed price:** $34.99 across 5 listings Full PT-141 (Bremelanotide) profile (https://www.bodyhackguide.co/compound/pt-141) ## N-Acetyl-Selank N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and… **Lowest listed price:** $79.99 across 2 listings Full N-Acetyl-Selank profile (https://www.bodyhackguide.co/compound/n-acetyl-selank) ## Side-by-side comparison | Attribute | PT-141 (Bremelanotide) | N-Acetyl-Selank | | --- | --- | --- | | Category | Skin, Hair & Aesthetics | Cognitive | | Research Stage | FDA Approved | Preclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in Russia | | Mechanism of Action | Melanocortin Receptor Pharmacology PT-141 is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-OH) that binds the melanocortin receptor family with the following selectivity profile: \| Receptor \| Primary Location \| PT-141 Activity \|… | N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown.… | | Half-Life | ~2.7 hours | Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature. | | Typical Dose Range | 500–2,000 mcg (0.5–2 mg) per dose | 100-900 mcg | | Dosing Frequency | As needed, 45 minutes before sexual activity; max once per 24 hours, max 8 doses/month | Once or twice daily (intranasal); some advanced users split into 2-3 doses | | Administration | Subcutaneous | — | | Side Effects | Very Common (10% of users) - Nausea — By far the most common adverse effect, affecting approximately 40% of users in the RECONNECT trials. Usually mild-to-moderate, begins within 30-60 minutes of injection, resolves within 2-4 hours. Can be mitigated with… | In short Russian clinical trials, parent Selank was generally well tolerated with no serious adverse effects reported [PMID:18454096]. Reported or plausible effects (largely extrapolated to the analog): mild nasal irritation or congestion from the spray,… | | Molecular Weight | 1025.2 Da | ~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10. | | Common Vial Sizes | 2mg, 10mg | — | ## Price History 5 data points - BM - Half Nattys - Ion Peptide - BHG Labs ## Price tracking Tracking N-Acetyl-Selank prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ### PT-141 (Bremelanotide): potential benefits - Sexual desire enhancement - HSDD treatment - Erectile dysfunction (central mechanism) - Non-hormonal approach ### N-Acetyl-Selank: potential benefits - Anxiolytic (calming) effects - the most-studied action of parent Selank, including a Russian clinical trial in generalized anxiety disorder [PMID:18454096] - Nootropic / cognitive support - reported attention and memory benefits in rodent models, linked to BDNF changes [PMID:31625062] - Stress resilience reported without the sedation, tolerance, or dependence typically seen with benzodiazepines (preclinical framing) [PMID:30255741] - Possible support during withdrawal states (alcohol, opioid) in animal models [PMID:24913576][PMID:36322304] - Claimed longer duration vs. plain Selank from N-terminal acetylation - a community/vendor claim not verified in published data ## Frequently asked ### What's the difference between PT-141 (Bremelanotide) and N-Acetyl-Selank? PT-141 (Bremelanotide) is a skin, hair & aesthetics that melanocortin receptor pharmacology pt-141 is a synthetic cyclic heptapeptide (ac-nle-cyclo[asp-his-dphe-arg-trp-lys]-oh) that binds the melanocortin receptor family with the…. N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (~2.7 hours vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range. ### Which has the longer half-life, PT-141 (Bremelanotide) or N-Acetyl-Selank? PT-141 (Bremelanotide) has a half-life of ~2.7 hours. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, PT-141 (Bremelanotide) or N-Acetyl-Selank? Lowest listed price on BodyHackGuide: PT-141 (Bremelanotide) from $34.99, N-Acetyl-Selank from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack PT-141 (Bremelanotide) and N-Acetyl-Selank? Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. PT-141 (Bremelanotide) prices: https://www.bodyhackguide.co/compound/pt-141?tab=prices N-Acetyl-Selank prices: https://www.bodyhackguide.co/compound/n-acetyl-selank?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy PT-141 (Bremelanotide) or N-Acetyl-Selank Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons N Acetyl Selank vs N Acetyl Semax: https://www.bodyhackguide.co/compare/n-acetyl-selank-vs-n-acetyl-semax PT-141 vs Melanotan Ii: https://www.bodyhackguide.co/compare/pt-141-vs-melanotan-ii **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "PT-141 (Bremelanotide) vs N-Acetyl-Selank" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "PT-141 vs N-Acetyl-Selank: Side-by-Side Comparison (2026)", "description": "Compare PT-141 vs N-Acetyl-Selank side by side. We earn a commission on some vendor links. 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N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (~2.7 hours vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, PT-141 (Bremelanotide) or N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "PT-141 (Bremelanotide) has a half-life of ~2.7 hours. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, PT-141 (Bremelanotide) or N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Lowest listed price on BodyHackGuide: PT-141 (Bremelanotide) from $34.99, N-Acetyl-Selank from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack PT-141 (Bremelanotide) and N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] ```