--- title: "PT-141 (Bremelanotide) vs Melanotan II: Side-by-Side" description: "Compare PT-141 (Bremelanotide) vs Melanotan II — mechanism, half-life, dose range, side effects, and live vendor pricing. PT-141 (Bremelanotide) from $29.99." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "PT-141 (Bremelanotide) vs Melanotan II" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "PT-141 (Bremelanotide) vs Melanotan II: Side-by-Side Comparison (2026)", "description": "Compare PT-141 (Bremelanotide) vs Melanotan II — mechanism, half-life, dose range, side effects, and live vendor pricing. PT-141 (Bremelanotide) from $29.99. Melanotan II from $34.99. 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Melanotan II is a skin, hair & aesthetics that melanotan-ii works by binding to and activating all four g-protein-coupled melanocortin receptors expressed in mammalian tissue (mc1r, mc3r, mc4r, mc5r - mc2r responds only to…. The two differ in mechanism, half-life (~2.7 hours vs Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours.), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, PT-141 (Bremelanotide) or Melanotan II?", "acceptedAnswer": { "@type": "Answer", "text": "PT-141 (Bremelanotide) has a half-life of ~2.7 hours. Melanotan II has a half-life of Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, PT-141 (Bremelanotide) or Melanotan II?", "acceptedAnswer": { "@type": "Answer", "text": "Current lowest live price on BodyHackGuide: PT-141 (Bremelanotide) from $29.99, Melanotan II from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack PT-141 (Bremelanotide) and Melanotan II?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and Melanotan II should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompare%2Fpt-141-vs-melanotan-ii) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compare](/compare) 3. PT-141 (Bremelanotide) vs Melanotan II # PT-141 (Bremelanotide) vs Melanotan II Side-by-side comparison of PT-141 (Bremelanotide) and Melanotan II: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land. PT-141 (Bremelanotide) from $29.99 Melanotan II from $34.99 ## Live price snapshot ### PT-141 (Bremelanotide) Current low $49.99 as of Sep 5, 2026 7-day low $49.99 30-day low $49.99 30-day change — baseline building ### Melanotan II Current low $54.99 as of Sep 5, 2026 7-day low $39.99 30-day low $39.99 30-day change — baseline building ## PT-141 (Bremelanotide) PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain — not peripherally on genital tissue — to improve sexual desire, arousal, and responsiveness. It is… **Live lowest price:** $29.99 across 8 vendors [Full PT-141 (Bremelanotide) profile](/compound/pt-141) ## Melanotan II Melanotan-II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) engineered in the late 1980s by researchers at the University of Arizona, most prominently Mac Hadley and… **Live lowest price:** $34.99 across 5 vendors [Full Melanotan II profile](/compound/melanotan-ii) ## Side-by-side comparison Attribute PT-141 (Bremelanotide) Melanotan II Category Skin, Hair & Aesthetics Skin, Hair & Aesthetics Research Stage FDA Approved Preclinical Mechanism of Action Melanocortin Receptor Pharmacology PT-141 is a synthetic cyclic heptapeptide (Ac-Nle-cyclo\[Asp-His-DPhe-Arg-Trp-Lys\]-OH) that binds the melanocortin receptor family with the following selectivity profile: | Receptor | Primary Location | PT-141 Activity |… Melanotan-II works by binding to and activating all four G-protein-coupled melanocortin receptors expressed in mammalian tissue (MC1R, MC3R, MC4R, MC5R - MC2R responds only to ACTH), with particularly high affinity at MC1R, MC3R, and MC4R. Melanocortin… Half-Life ~2.7 hours Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours. Typical Dose Range 500–2,000 mcg (0.5–2 mg) per dose — Dosing Frequency As needed, 45 minutes before sexual activity; max once per 24 hours, max 8 doses/month — Administration Subcutaneous — Side Effects Very Common (10% of users) - Nausea — By far the most common adverse effect, affecting approximately 40% of users in the RECONNECT trials. Usually mild-to-moderate, begins within 30-60 minutes of injection, resolves within 2-4 hours. Can be mitigated with… The side-effect profile of MT-II is dose-dependent and largely driven by pan-melanocortin receptor activation. Many users experience the acute side effects as more limiting than the tanning benefit. Very Common (50% of users): - Nausea — the single most common… Molecular Weight 1025.2 Da ~1024.2 g/mol (average molecular weight; monoisotopic mass ~1023.5 Da). Molecular formula C50H69N15O9 (PubChem CID 92432). Common Vial Sizes 2mg, 10mg — ## Price History 8 data points - OF - BM - Unknown - VANDL Labs - Unknown - Ion Peptide - BHG Labs - Disguised Alpha ## Price History 4 data points - VANDL Labs - Unknown - Ion Peptide - Disguised Alpha ### PT-141 (Bremelanotide) — potential benefits - Sexual desire enhancement - HSDD treatment - Erectile dysfunction (central mechanism) - Non-hormonal approach ### Melanotan II — potential benefits - Tanning without UV - Appetite suppression - Sexual arousal - Photoprotection - Fat loss ## Frequently asked ### What's the difference between PT-141 (Bremelanotide) and Melanotan II? PT-141 (Bremelanotide) is a skin, hair & aesthetics that melanocortin receptor pharmacology pt-141 is a synthetic cyclic heptapeptide (ac-nle-cyclo\[asp-his-dphe-arg-trp-lys\]-oh) that binds the melanocortin receptor family with the…. Melanotan II is a skin, hair & aesthetics that melanotan-ii works by binding to and activating all four g-protein-coupled melanocortin receptors expressed in mammalian tissue (mc1r, mc3r, mc4r, mc5r - mc2r responds only to…. The two differ in mechanism, half-life (~2.7 hours vs Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours.), and typical dose range. ### Which has the longer half-life, PT-141 (Bremelanotide) or Melanotan II? PT-141 (Bremelanotide) has a half-life of ~2.7 hours. Melanotan II has a half-life of Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, PT-141 (Bremelanotide) or Melanotan II? Current lowest live price on BodyHackGuide: PT-141 (Bremelanotide) from $29.99, Melanotan II from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers. ### Can you stack PT-141 (Bremelanotide) and Melanotan II? Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and Melanotan II should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Live listings from the vendors we track, refreshed continuously. [PT-141 (Bremelanotide) prices](/compound/pt-141?tab=prices) [Melanotan II prices](/compound/melanotan-ii?tab=prices) [Compare all compounds](/compare) ### Before you buy PT-141 (Bremelanotide) or Melanotan II Check the vendor trust score. Every supplier we track is rated 0–100 on COA verification, payment transparency, shipping, reviews, and listings — one published, reproducible methodology, applied to every vendor including BHG Labs, which shares our ownership. [View Vendor Scorecard](/vendors/scorecard) ## Related comparisons [Melanotan I vs Melanotan Ii](/compare/melanotan-i-vs-melanotan-ii)[GHK CU vs AHK CU](/compare/ghk-cu-vs-ahk-cu) **Research use only.** BodyHackGuide is a research and price-comparison reference. BodyHackGuide and BHG Labs share common ownership. 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