--- title: "Pinealon vs Epithalon: Side-by-Side Comparison (2026)" description: "Compare Pinealon vs Epithalon — mechanism, half-life, dose range, side effects, and live vendor pricing. Pinealon from $36.99. Epithalon from $34.99." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Pinealon vs Epithalon" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "Pinealon vs Epithalon: Side-by-Side Comparison (2026)", "description": "Compare Pinealon vs Epithalon — mechanism, half-life, dose range, side effects, and live vendor pricing. Pinealon from $36.99. Epithalon from $34.99. 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Epithalon is a longevity & cellular health that epithalon (aedg; ala-glu-asp-gly) is a synthetic tetrapeptide modeled on the pineal polypeptide preparation epithalamin. its proposed mechanism spans several parallel pathways. the…. The two differ in mechanism, half-life (Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing. vs Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate.), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, Pinealon or Epithalon?", "acceptedAnswer": { "@type": "Answer", "text": "Pinealon has a half-life of Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.. Epithalon has a half-life of Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, Pinealon or Epithalon?", "acceptedAnswer": { "@type": "Answer", "text": "Current lowest live price on BodyHackGuide: Pinealon from $36.99, Epithalon from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack Pinealon and Epithalon?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. Pinealon and Epithalon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompare%2Fpinealon-vs-epithalon) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compare](/compare) 3. Pinealon vs Epithalon # Pinealon vs Epithalon Side-by-side comparison of Pinealon and Epithalon: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land. Pinealon from $36.99 Epithalon from $34.99 ## Live price snapshot ### Pinealon Current low $59.99 as of Sep 5, 2026 7-day low $59.99 30-day low $59.99 30-day change — baseline building ### Epithalon Current low $44.99 as of Sep 5, 2026 7-day low $44.99 30-day low $44.99 30-day change — baseline building ## Pinealon Pinealon is a synthetic tripeptide — glutamyl-aspartyl-arginine (Glu-Asp-Arg, or EDR) — developed by the St Petersburg Institute of Bioregulation and Gerontology (IBG) under the leadership of Professor Vladimir… **Live lowest price:** $36.99 across 4 vendors [Full Pinealon profile](/compound/pinealon) ## Epithalon Epithalon (also spelled Epitalon, sequence Ala-Glu-Asp-Gly / AEDG) is a synthetic tetrapeptide designed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s as a… **Live lowest price:** $34.99 across 4 vendors [Full Epithalon profile](/compound/epithalon) ## Side-by-side comparison Attribute Pinealon Epithalon Category Nootropics Longevity & Cellular Health Research Stage Preclinical Preclinical (Western standards); Used clinically in Russian gerontological medicine Mechanism of Action The proposed mechanism of Pinealon is rooted in the Khavinson school's broader theory of short-peptide tissue-specific bioregulation. The full theory is worth understanding because it underlies all twelve Russian bioregulator compounds in this catalog. The… Epithalon (AEDG; Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled on the pineal polypeptide preparation epithalamin. Its proposed mechanism spans several parallel pathways. The human-relevant evidence is strongest for melatonin/circadian effects; the… Half-Life Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing. Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate. Typical Dose Range Subcutaneous (primary route): 2-10 mg/day, typically 3-5 mg, in pulsed 10-20 day cycles, 2-4 cycles/year. Intranasal: 150-800 mcg per nostril daily. Research use only; oral dosing is not recommended because the peptide is largely degraded by GI proteases. 5000-10000 mcg (5-10 mg) subcutaneous daily for 10-20 day cycles; typically repeated 1-2 times per year in anti-aging protocols Dosing Frequency Once daily during a cycle (morning preferred); some advanced users split into AM + midday doses. Not dosed continuously year-round - cycles are pulsed. Once daily for 10–20 day cycles Administration — Subcutaneous Side Effects The side-effect profile of Pinealon, based on the available Russian clinical literature and user-reported experience, is described as mild and uncommon. Whether this reflects genuinely low toxicity or inadequate reporting in the available studies is a… Expected / benign - Mild injection-site reaction — redness, slight tenderness, occasional small bruise. Resolves within 24-48 hours. - Enhanced, more vivid dreams in the first week of a cycle — consistent with melatonin rise. - Deeper sleep onset and feeling… Molecular Weight 418.40 g/mol (C15H26N6O8) 390.3 Da Common Vial Sizes — 10mg, 50mg ## Price History 4 data points - VANDL Labs - GetMelts - Ion Peptide - Disguised Alpha ## Price History 4 data points - VANDL Labs - Unknown - Ion Peptide - Disguised Alpha ### Pinealon — potential benefits - Neuroprotection against oxidative and hypoxic stress (preclinical models) - Antioxidant support - reduced oxidative DNA damage in aged neurons (in vitro) - Cognitive and memory support in aging populations (small Russian clinical reports) - Reduced neuronal apoptosis and support of dendritic-tree integrity in cell models - Investigated for neuroprotection in Alzheimer's-model systems (preclinical) ### Epithalon — potential benefits - Telomerase activation and telomere elongation (human cell culture) - Normalization of circadian melatonin rhythm (human data from epithalamin, the parent pineal preparation) - Improved sleep consolidation and circadian regularity (subjective) - Modest life-span effects in rodents (mainly maximum / late-survivor lifespan; no change in mean lifespan) - Reduced incidence of specific tumors (e.g. ~6-fold fewer leukemias in SHR mice); no change in total tumor incidence - Reduced chromosomal aberrations in aged rodent tissue - Site-specific DNA / chromatin binding (proposed epigenetic modulation) - Association with lower mortality in an elderly cardiovascular cohort (epithalamin RCT, Korkushko 2011) ## Frequently asked ### What's the difference between Pinealon and Epithalon? Pinealon is a nootropics that the proposed mechanism of pinealon is rooted in the khavinson school's broader theory of short-peptide tissue-specific bioregulation. the full theory is worth understanding because…. Epithalon is a longevity & cellular health that epithalon (aedg; ala-glu-asp-gly) is a synthetic tetrapeptide modeled on the pineal polypeptide preparation epithalamin. its proposed mechanism spans several parallel pathways. the…. The two differ in mechanism, half-life (Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing. vs Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate.), and typical dose range. ### Which has the longer half-life, Pinealon or Epithalon? Pinealon has a half-life of Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.. Epithalon has a half-life of Not well characterized in humans. As a small tetrapeptide, AEDG is expected to have a very short plasma half-life (on the order of minutes), while downstream gene-expression and circadian effects are thought to persist considerably longer. Any specific half-life figure should be treated as an unvalidated estimate.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Pinealon or Epithalon? Current lowest live price on BodyHackGuide: Pinealon from $36.99, Epithalon from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers. ### Can you stack Pinealon and Epithalon? Stacking depends on mechanism overlap, safety profile, and goals. Pinealon and Epithalon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Live listings from the vendors we track, refreshed continuously. 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