--- title: "Phenylpiracetam vs Semax: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/phenylpiracetam-vs-semax description: "Compare Phenylpiracetam vs Semax side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Phenylpiracetam vs Semax Side-by-side comparison of Phenylpiracetam and Semax: mechanism, half-life, dose range, safety profile, and vendor pricing. Phenylpiracetam from $84.99 Semax from $32.90 ## Price snapshot ### Phenylpiracetam Current low $84.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### Semax Current low $32.90 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Phenylpiracetam Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery.… **Lowest listed price:** $84.99 across 1 listing Full Phenylpiracetam profile (https://www.bodyhackguide.co/compound/phenylpiracetam) ## Semax Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro, MEHFPGP, 813 Da molecular weight) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s. The compound is derived… **Lowest listed price:** $32.90 across 5 listings Full Semax profile (https://www.bodyhackguide.co/compound/semax) ## Side-by-side comparison | Attribute | Phenylpiracetam | Semax | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Preclinical | Approved (Russia, since mid-1990s for stroke and cognitive disorders) | | Mechanism of Action | Phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. It upregulates dopamine, norepinephrine, and serotonin receptor density — rather than triggering release — explaining the… | Primary Mechanism: Multi-Pathway Neurotrophic Activation Semax produces its effects through coordinated activation of multiple neurotrophic, neurotransmitter, and neuroprotective pathways. Unlike conventional nootropics that target a single system (modafinil… | | Half-Life | — | ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes) | | Typical Dose Range | — | 100-900 mcg intranasal daily (0.1% solution: 2-3 drops per nostril 2-3x daily); 1% solution used for acute stroke in Russian clinical protocols | | Dosing Frequency | — | Intranasal 1–3 times daily | | Administration | — | Intranasal | | Side Effects | Insomnia (if taken late), headache, slight anxiety at initiation, overstimulation at high doses. Generally well-tolerated. | Overall Safety Profile Semax has an excellent safety profile across 20+ years of Russian clinical use. In acute stroke trials, cognitive studies, and pediatric applications, Semax has demonstrated consistent tolerability with minimal adverse event burden. This… | | Molecular Weight | 218.25 g/mol | 813.9 Da | | Common Vial Sizes | — | 5mg, 10mg | ## Price tracking Tracking Phenylpiracetam prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price History 5 data points - OF - Half Nattys - Ion Peptide - BHG Labs ### Phenylpiracetam: potential benefits - Cognitive stimulation - Physical performance - Memory enhancement - Cold tolerance - Motivation - Anti-convulsant ### Semax: potential benefits - Rapid BDNF/TrkB upregulation in the hippocampus, supporting synaptic plasticity and learning (PMID: 16996037) - Neuroprotective, immunomodulatory gene-expression changes in focal cerebral ischemia (middle cerebral artery occlusion) models (PMID: 28255762) - Cognitive enhancement including improved attention, working memory, and processing speed - Dopaminergic modulation that may support motivation and executive function (preclinical data) - Stroke recovery facilitation - accelerated functional recovery and improved Barthel Index in ischemic stroke patients; approved in Russia for ischemic stroke (PMID: 29798983) - Anxiolytic and anti-asthenic effects reported in Russian clinical use, attributed to neurotrophic and monoaminergic modulation - Non-addictive cognitive support without tolerance development or withdrawal at standard doses ## Frequently asked ### What's the difference between Phenylpiracetam and Semax? Phenylpiracetam is a nootropics that phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. it upregulates dopamine, norepinephrine, and…. Semax is a nootropics that primary mechanism: multi-pathway neurotrophic activation semax produces its effects through coordinated activation of multiple neurotrophic, neurotransmitter, and neuroprotective…. The two differ in mechanism, half-life (not reported vs ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes)), and typical dose range. ### Which has the longer half-life, Phenylpiracetam or Semax? Phenylpiracetam has a half-life of not reported. Semax has a half-life of ~2-3 minutes plasma half-life (functional neurological effects persist 12-24 hours due to BDNF/NGF gene expression changes). Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Phenylpiracetam or Semax? Lowest listed price on BodyHackGuide: Phenylpiracetam from $84.99, Semax from $32.90. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack Phenylpiracetam and Semax? Stacking depends on mechanism overlap, safety profile, and goals. Phenylpiracetam and Semax should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Phenylpiracetam prices: https://www.bodyhackguide.co/compound/phenylpiracetam?tab=prices Semax prices: https://www.bodyhackguide.co/compound/semax?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Phenylpiracetam or Semax Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Selank vs Semax: https://www.bodyhackguide.co/compare/selank-vs-semax Phenylpiracetam vs Piracetam: https://www.bodyhackguide.co/compare/phenylpiracetam-vs-piracetam Modafinil vs Phenylpiracetam: https://www.bodyhackguide.co/compare/modafinil-vs-phenylpiracetam **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). 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