--- title: "Phenylpiracetam vs PE-22-28: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/phenylpiracetam-vs-pe-22-28 description: "Compare Phenylpiracetam vs PE-22-28 side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Phenylpiracetam vs PE-22-28 Side-by-side comparison of Phenylpiracetam and PE-22-28: mechanism, half-life, dose range, safety profile, and vendor pricing. Phenylpiracetam from $84.99 PE-22-28 from $54.99 ## Price snapshot ### Phenylpiracetam Current low $84.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### PE-22-28 Current low $54.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Phenylpiracetam Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery.… **Lowest listed price:** $84.99 across 1 listing Full Phenylpiracetam profile (https://www.bodyhackguide.co/compound/phenylpiracetam) ## PE-22-28 PE-22-28 is a synthetic seven-amino-acid peptide (sequence PAGASRLLLLTGEIDLP derivative, commonly truncated to PE-22-28 as shorthand for "position 22-28" within the parent humanin-family sequence) that was designed as an… **Lowest listed price:** $54.99 across 1 listing Full PE-22-28 profile (https://www.bodyhackguide.co/compound/pe-22-28) ## Side-by-side comparison | Attribute | Phenylpiracetam | PE-22-28 | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Preclinical | Preclinical | | Mechanism of Action | Phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. It upregulates dopamine, norepinephrine, and serotonin receptor density — rather than triggering release — explaining the… | PE-22-28 is a synthetic 7-amino-acid peptide (sequence GVSWGLR) and a shortened analog of spadin. Its proposed mechanism is inhibition of the TREK-1 (TWIK-related K+) channel, a two-pore-domain potassium channel (K2P2.1 / KCNK2) implicated in mood regulation.… | | Half-Life | — | Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. | | Typical Dose Range | — | 250-2000 mcg subcutaneous per dose (empirical research-chemical community range; no clinically validated human dose exists; effective preclinical rodent doses were far lower, ~3 mcg/kg). | | Dosing Frequency | — | Once daily or every other day (research-chemical community protocols; no validated clinical dosing schedule). | | Administration | — | — | | Side Effects | Insomnia (if taken late), headache, slight anxiety at initiation, overstimulation at high doses. Generally well-tolerated. | No human side-effect data exist for PE-22-28 because it has never been tested in people. What can be said comes from rodent studies of PE-22-28, spadin and their analogs, plus general considerations for injected research peptides. In the preclinical work, the… | | Molecular Weight | 218.25 g/mol | 773.9 g/mol | | Common Vial Sizes | — | — | ## Price tracking Tracking Phenylpiracetam prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price tracking Tracking PE-22-28 prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ### Phenylpiracetam: potential benefits - Cognitive stimulation - Physical performance - Memory enhancement - Cold tolerance - Motivation - Anti-convulsant ### PE-22-28: potential benefits - Antidepressant-like effects in rodent models of depression (preclinical only) - Potent, selective inhibition of the TREK-1 (K2P2.1) potassium channel (IC50 ~0.12 nM) - Rapid-onset (~4-day) antidepressant profile in animals, unlike the multi-week lag of SSRIs - Increased hippocampal neurogenesis in mice - Increased cortical synaptogenesis (PSD-95) and BDNF expression in preclinical studies - No human-validated benefits; not approved for any use (research use only) ## Frequently asked ### What's the difference between Phenylpiracetam and PE-22-28? Phenylpiracetam is a nootropics that phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. it upregulates dopamine, norepinephrine, and…. PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range. ### Which has the longer half-life, Phenylpiracetam or PE-22-28? Phenylpiracetam has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Phenylpiracetam or PE-22-28? Lowest listed price on BodyHackGuide: Phenylpiracetam from $84.99, PE-22-28 from $54.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack Phenylpiracetam and PE-22-28? Stacking depends on mechanism overlap, safety profile, and goals. Phenylpiracetam and PE-22-28 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Phenylpiracetam prices: https://www.bodyhackguide.co/compound/phenylpiracetam?tab=prices PE-22-28 prices: https://www.bodyhackguide.co/compound/pe-22-28?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Phenylpiracetam or PE-22-28 Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Phenylpiracetam vs Piracetam: https://www.bodyhackguide.co/compare/phenylpiracetam-vs-piracetam Modafinil vs Phenylpiracetam: https://www.bodyhackguide.co/compare/modafinil-vs-phenylpiracetam **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Phenylpiracetam vs PE-22-28" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "Phenylpiracetam vs PE-22-28: Side-by-Side Comparison (2026)", "description": "Compare Phenylpiracetam vs PE-22-28 side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices.", "url": "https://www.bodyhackguide.co/compare/phenylpiracetam-vs-pe-22-28", "dateModified": "2026-10-26", "isPartOf": { "@type": "WebSite", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainEntity": { "@type": "ItemList", "itemListElement": [ { "@type": "ListItem", "position": 1, "item": { "@type": "Product", "name": "Phenylpiracetam", "description": "Phenylpiracetam is a Russian-developed phenyl derivative of piracetam with a dramatically higher potency and stimulant profile. Approved in Russia as Phenotropil/Carphedon for cognitive impairment and stroke recovery. Banned by WADA as a performance-improving drug due to its stimulant effects,…", "url": "https://www.bodyhackguide.co/compound/phenylpiracetam", "category": "Nootropics", "offers": { "@type": "AggregateOffer", "lowPrice": "84.99", "priceCurrency": "USD", "offerCount": 1 } } }, { "@type": "ListItem", "position": 2, "item": { "@type": "Product", "name": "PE-22-28", "description": "PE-22-28 is a synthetic seven-amino-acid peptide (sequence PAGASRLLLLTGEIDLP derivative, commonly truncated to PE-22-28 as shorthand for \"position 22-28\" within the parent humanin-family sequence) that was designed as an analog of Humanin with specific interest in activity at glutamate transporter…", "url": "https://www.bodyhackguide.co/compound/pe-22-28", "category": "Nootropics", "offers": { "@type": "AggregateOffer", "lowPrice": "54.99", "priceCurrency": "USD", "offerCount": 1 } } } ] } }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 273 compound profiles, interactive dosing calculators, vendor price comparisons, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. We earn a commission on purchases through some of our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What's the difference between Phenylpiracetam and PE-22-28?", "acceptedAnswer": { "@type": "Answer", "text": "Phenylpiracetam is a nootropics that phenylpiracetam's phenyl group addition dramatically increases lipophilicity and blood-brain barrier penetration compared to piracetam. it upregulates dopamine, norepinephrine, and…. PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, Phenylpiracetam or PE-22-28?", "acceptedAnswer": { "@type": "Answer", "text": "Phenylpiracetam has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, Phenylpiracetam or PE-22-28?", "acceptedAnswer": { "@type": "Answer", "text": "Lowest listed price on BodyHackGuide: Phenylpiracetam from $84.99, PE-22-28 from $54.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack Phenylpiracetam and PE-22-28?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. Phenylpiracetam and PE-22-28 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] ```