--- title: "Phenibut vs N-Acetyl-Selank: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/phenibut-vs-n-acetyl-selank description: "Compare Phenibut vs N-Acetyl-Selank side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Phenibut vs N-Acetyl-Selank Side-by-side comparison of Phenibut and N-Acetyl-Selank: mechanism, half-life, dose range, safety profile, and vendor pricing. Phenibut from $49.99 N-Acetyl-Selank from $79.99 ## Price snapshot ### Phenibut Current low $49.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### N-Acetyl-Selank Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Phenibut Phenibut is the common Western name for β-phenyl-γ-aminobutyric acid (beta-phenyl-GABA; Russian trade names Phenibut/Фенибут, Noofen, Anvifen), a Soviet-era anxiolytic and nootropic developed in the 1960s at the Herzen… **Lowest listed price:** $49.99 across 1 listing Full Phenibut profile (https://www.bodyhackguide.co/compound/phenibut) ## N-Acetyl-Selank N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and… **Lowest listed price:** $79.99 across 2 listings Full N-Acetyl-Selank profile (https://www.bodyhackguide.co/compound/n-acetyl-selank) ## Side-by-side comparison | Attribute | Phenibut | N-Acetyl-Selank | | --- | --- | --- | | Category | Nootropics | Cognitive | | Research Stage | Prescription Medicine (Russia/CIS) / Unregulated Elsewhere | Preclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in Russia | | Mechanism of Action | Phenibut's pharmacology is dominated by activity at the GABA-B receptor, with secondary effects at GABA-A receptors and voltage-gated calcium channels. Understanding these three components is essential to understanding both its therapeutic effects and its… | N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown.… | | Half-Life | 5-8 hours (plasma); central CNS effect 10-16 hours | Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature. | | Typical Dose Range | — | 100-900 mcg | | Dosing Frequency | — | Once or twice daily (intranasal); some advanced users split into 2-3 doses | | Administration | Oral | — | | Side Effects | Phenibut's side effects fall into three categories: acute-dose effects (largely dose-dependent sedation and impairment), withdrawal effects (physiologically similar to benzodiazepine/alcohol withdrawal), and interactions with other CNS depressants (additive… | In short Russian clinical trials, parent Selank was generally well tolerated with no serious adverse effects reported [PMID:18454096]. Reported or plausible effects (largely extrapolated to the analog): mild nasal irritation or congestion from the spray,… | | Molecular Weight | 179.22 g/mol (free base); 215.68 g/mol (HCl salt) | ~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10. | | Common Vial Sizes | — | — | ## Price tracking Tracking Phenibut prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price tracking Tracking N-Acetyl-Selank prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ### Phenibut: potential benefits - No structured benefit list published. ### N-Acetyl-Selank: potential benefits - Anxiolytic (calming) effects - the most-studied action of parent Selank, including a Russian clinical trial in generalized anxiety disorder [PMID:18454096] - Nootropic / cognitive support - reported attention and memory benefits in rodent models, linked to BDNF changes [PMID:31625062] - Stress resilience reported without the sedation, tolerance, or dependence typically seen with benzodiazepines (preclinical framing) [PMID:30255741] - Possible support during withdrawal states (alcohol, opioid) in animal models [PMID:24913576][PMID:36322304] - Claimed longer duration vs. plain Selank from N-terminal acetylation - a community/vendor claim not verified in published data ## Frequently asked ### What's the difference between Phenibut and N-Acetyl-Selank? Phenibut is a nootropics that phenibut's pharmacology is dominated by activity at the gaba-b receptor, with secondary effects at gaba-a receptors and voltage-gated calcium channels. understanding these three…. N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (5-8 hours (plasma); central CNS effect 10-16 hours vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range. ### Which has the longer half-life, Phenibut or N-Acetyl-Selank? Phenibut has a half-life of 5-8 hours (plasma); central CNS effect 10-16 hours. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Phenibut or N-Acetyl-Selank? Lowest listed price on BodyHackGuide: Phenibut from $49.99, N-Acetyl-Selank from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack Phenibut and N-Acetyl-Selank? Stacking depends on mechanism overlap, safety profile, and goals. Phenibut and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Phenibut prices: https://www.bodyhackguide.co/compound/phenibut?tab=prices N-Acetyl-Selank prices: https://www.bodyhackguide.co/compound/n-acetyl-selank?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Phenibut or N-Acetyl-Selank Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons N Acetyl Selank vs N Acetyl Semax: https://www.bodyhackguide.co/compare/n-acetyl-selank-vs-n-acetyl-semax Selank vs Phenibut: https://www.bodyhackguide.co/compare/selank-vs-phenibut **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). 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All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Phenibut vs N-Acetyl-Selank" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "Phenibut vs N-Acetyl-Selank: Side-by-Side Comparison (2026)", "description": "Compare Phenibut vs N-Acetyl-Selank side by side. We earn a commission on some vendor links. 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N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (5-8 hours (plasma); central CNS effect 10-16 hours vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, Phenibut or N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Phenibut has a half-life of 5-8 hours (plasma); central CNS effect 10-16 hours. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, Phenibut or N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Lowest listed price on BodyHackGuide: Phenibut from $49.99, N-Acetyl-Selank from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack Phenibut and N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. Phenibut and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] ```