--- title: "PE-22-28 vs Noopept: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/pe-22-28-vs-noopept description: "Compare PE-22-28 vs Noopept side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # PE-22-28 vs Noopept Side-by-side comparison of PE-22-28 and Noopept: mechanism, half-life, dose range, safety profile, and vendor pricing. PE-22-28 from $54.99 Noopept from $49.99 ## Price snapshot ### PE-22-28 Current low $54.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### Noopept Current low $49.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## PE-22-28 PE-22-28 is a synthetic seven-amino-acid peptide (sequence PAGASRLLLLTGEIDLP derivative, commonly truncated to PE-22-28 as shorthand for "position 22-28" within the parent humanin-family sequence) that was designed as an… **Lowest listed price:** $54.99 across 1 listing Full PE-22-28 profile (https://www.bodyhackguide.co/compound/pe-22-28) ## Noopept Noopept is the common brand and research name for N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111; INN omberacetam), a small dipeptide nootropic developed in the 1990s at the Russian Academy of Medical Sciences'… **Lowest listed price:** $49.99 across 1 listing Full Noopept profile (https://www.bodyhackguide.co/compound/noopept) ## Side-by-side comparison | Attribute | PE-22-28 | Noopept | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Preclinical | Preclinical | | Mechanism of Action | PE-22-28 is a synthetic 7-amino-acid peptide (sequence GVSWGLR) and a shortened analog of spadin. Its proposed mechanism is inhibition of the TREK-1 (TWIK-related K+) channel, a two-pore-domain potassium channel (K2P2.1 / KCNK2) implicated in mood regulation.… | Noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. Several convergent pathways have been proposed, each supported by preclinical data but none definitively established as the primary driver of its… | | Half-Life | Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. | — | | Typical Dose Range | 250-2000 mcg subcutaneous per dose (empirical research-chemical community range; no clinically validated human dose exists; effective preclinical rodent doses were far lower, ~3 mcg/kg). | — | | Dosing Frequency | Once daily or every other day (research-chemical community protocols; no validated clinical dosing schedule). | — | | Administration | — | — | | Side Effects | No human side-effect data exist for PE-22-28 because it has never been tested in people. What can be said comes from rodent studies of PE-22-28, spadin and their analogs, plus general considerations for injected research peptides. In the preclinical work, the… | Noopept is generally well tolerated in the Russian clinical literature, with side effects that are typically mild and transient. However, "well tolerated in Russian open-label trials" is a weaker safety claim than the rigorous multi-phase trial data underlying… | | Molecular Weight | 773.9 g/mol | 318.37 g/mol | | Common Vial Sizes | — | — | ## Price tracking Tracking PE-22-28 prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price History 2 data points ### PE-22-28: potential benefits - Antidepressant-like effects in rodent models of depression (preclinical only) - Potent, selective inhibition of the TREK-1 (K2P2.1) potassium channel (IC50 ~0.12 nM) - Rapid-onset (~4-day) antidepressant profile in animals, unlike the multi-week lag of SSRIs - Increased hippocampal neurogenesis in mice - Increased cortical synaptogenesis (PSD-95) and BDNF expression in preclinical studies - No human-validated benefits; not approved for any use (research use only) ### Noopept: potential benefits - Memory enhancement - BDNF/NGF upregulation - Neuroprotection - Focus and learning speed - Anxiety reduction (moderate) - Anti-amyloid properties ## Frequently asked ### What's the difference between PE-22-28 and Noopept? PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. Noopept is a nootropics that noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. several convergent pathways have been proposed, each supported by…. The two differ in mechanism, half-life (Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. vs not reported), and typical dose range. ### Which has the longer half-life, PE-22-28 or Noopept? PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Noopept has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, PE-22-28 or Noopept? Lowest listed price on BodyHackGuide: PE-22-28 from $54.99, Noopept from $49.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack PE-22-28 and Noopept? Stacking depends on mechanism overlap, safety profile, and goals. PE-22-28 and Noopept should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. PE-22-28 prices: https://www.bodyhackguide.co/compound/pe-22-28?tab=prices Noopept prices: https://www.bodyhackguide.co/compound/noopept?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy PE-22-28 or Noopept Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Noopept vs Piracetam: https://www.bodyhackguide.co/compare/noopept-vs-piracetam Dihexa vs Noopept: https://www.bodyhackguide.co/compare/dihexa-vs-noopept **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "PE-22-28 vs Noopept" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "PE-22-28 vs Noopept: Side-by-Side Comparison (2026)", "description": "Compare PE-22-28 vs Noopept side by side. We earn a commission on some vendor links. 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Noopept is a nootropics that noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. several convergent pathways have been proposed, each supported by…. The two differ in mechanism, half-life (Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. vs not reported), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, PE-22-28 or Noopept?", "acceptedAnswer": { "@type": "Answer", "text": "PE-22-28 has a half-life of Not characterized in humans. 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