--- title: "NSI-189 vs Selank: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/nsi-189-vs-selank description: "Compare NSI-189 vs Selank side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # NSI-189 vs Selank Side-by-side comparison of NSI-189 and Selank: mechanism, half-life, dose range, safety profile, and vendor pricing. NSI-189 from $84.99 Selank from $25.00 ## Price snapshot ### NSI-189 Current low $84.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### Selank Current low $25.00 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## NSI-189 NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus. Phase 2 trials for major depressive disorder showed improvements in subjective cognitive function,… **Lowest listed price:** $84.99 across 1 listing Full NSI-189 profile (https://www.bodyhackguide.co/compound/nsi-189) ## Selank Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin… **Lowest listed price:** $25.00 across 6 listings Full Selank profile (https://www.bodyhackguide.co/compound/selank) ## Side-by-side comparison | Attribute | NSI-189 | Selank | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Preclinical | Approved (Russia, as anxiolytic and nootropic medication) | | Mechanism of Action | NSI-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from BDNF or classical antidepressants. Rodent studies show a 20% increase in hippocampal volume after 6 weeks of treatment. It is not a… | Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… | | Half-Life | — | ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) | | Typical Dose Range | — | 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days | | Dosing Frequency | — | Intranasal 1–3 times daily | | Administration | — | Intranasal | | Side Effects | Mild GI discomfort, injection site reaction (if injected), headache. Very well-tolerated. Rare: anxiety or insomnia at high doses. | Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… | | Molecular Weight | 313.36 g/mol | 751.9 Da | | Common Vial Sizes | — | 5mg, 10mg | ## Price tracking Tracking NSI-189 prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price History 5 data points - OF - Half Nattys - Ion Peptide - BHG Labs ### NSI-189: potential benefits - Increased hippocampal neurogenesis - Antidepressant effects - Enhanced synaptic plasticity - Improved cognitive function - Long-lasting mood improvement - Potential PTSD treatment ### Selank: potential benefits - Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096) - Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741) - Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961) - Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804) - Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852) - Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation - Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use ## Frequently asked ### What's the difference between NSI-189 and Selank? NSI-189 is a nootropics that nsi-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from bdnf or classical antidepressants. rodent studies show…. Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. The two differ in mechanism, half-life (not reported vs ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation)), and typical dose range. ### Which has the longer half-life, NSI-189 or Selank? NSI-189 has a half-life of not reported. Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, NSI-189 or Selank? Lowest listed price on BodyHackGuide: NSI-189 from $84.99, Selank from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack NSI-189 and Selank? Stacking depends on mechanism overlap, safety profile, and goals. NSI-189 and Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. NSI-189 prices: https://www.bodyhackguide.co/compound/nsi-189?tab=prices Selank prices: https://www.bodyhackguide.co/compound/selank?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy NSI-189 or Selank Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Selank vs Semax: https://www.bodyhackguide.co/compare/selank-vs-semax Selank vs Phenibut: https://www.bodyhackguide.co/compare/selank-vs-phenibut **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "NSI-189 vs Selank" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "NSI-189 vs Selank: Side-by-Side Comparison (2026)", "description": "Compare NSI-189 vs Selank side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices.", "url": "https://www.bodyhackguide.co/compare/nsi-189-vs-selank", "dateModified": "2026-10-26", "isPartOf": { "@type": "WebSite", "name": "BodyHackGuide", "url": "https://www.bodyhackguide.co" }, "mainEntity": { "@type": "ItemList", "itemListElement": [ { "@type": "ListItem", "position": 1, "item": { "@type": "Product", "name": "NSI-189", "description": "NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus. Phase 2 trials for major depressive disorder showed improvements in subjective cognitive function, depression scores, and positive affect despite not reaching primary endpoints.…", "url": "https://www.bodyhackguide.co/compound/nsi-189", "category": "Nootropics", "offers": { "@type": "AggregateOffer", "lowPrice": "84.99", "priceCurrency": "USD", "offerCount": 1 } } }, { "@type": "ListItem", "position": 2, "item": { "@type": "Product", "name": "Selank", "description": "Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin — an immunomodulatory tetrapeptide (Thr-Lys-Pro-Arg) that is naturally cleaved…", "url": "https://www.bodyhackguide.co/compound/selank", "category": "Nootropics", "offers": { "@type": "AggregateOffer", "lowPrice": "25.00", "priceCurrency": "USD", "offerCount": 6 } } } ] } }, { "@context": "https://schema.org", "@type": "Organization", "@id": "https://www.bodyhackguide.co#organization", "name": "BodyHackGuide", "alternateName": "BHG", "url": "https://www.bodyhackguide.co", "logo": { "@type": "ImageObject", "url": "https://www.bodyhackguide.co/logo.png", "width": 512, "height": 512 }, "description": "Evidence-based research reference for peptides and nootropics. 273 compound profiles, interactive dosing calculators, vendor price comparisons, and trust-scored vendor reviews scored on a public, reproducible methodology applied to every vendor. We earn a commission on purchases through some of our links.", "foundingDate": "2024", "founder": { "@id": "https://www.bodyhackguide.co/about#person" }, "sameAs": [ "https://reddit.com/r/BodyHackGuide", "https://reddit.com/r/BrainHackGuide", "https://reddit.com/r/Biohackingher", "https://discord.gg/Mhq5UdRYBA" ], "knowsAbout": [ "Peptide research", "Nootropic research", "Biohacking", "Compound dosing", "Vendor transparency" ], "publishingPrinciples": "https://www.bodyhackguide.co/editorial-standards", "ethicsPolicy": "https://www.bodyhackguide.co/editorial-standards", "diversityPolicy": "https://www.bodyhackguide.co/editorial-standards" }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What's the difference between NSI-189 and Selank?", "acceptedAnswer": { "@type": "Answer", "text": "NSI-189 is a nootropics that nsi-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from bdnf or classical antidepressants. rodent studies show…. Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. The two differ in mechanism, half-life (not reported vs ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation)), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, NSI-189 or Selank?", "acceptedAnswer": { "@type": "Answer", "text": "NSI-189 has a half-life of not reported. Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, NSI-189 or Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Lowest listed price on BodyHackGuide: NSI-189 from $84.99, Selank from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack NSI-189 and Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. NSI-189 and Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] ```