--- title: "NSI-189 vs Noopept: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/nsi-189-vs-noopept description: "Compare NSI-189 vs Noopept side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # NSI-189 vs Noopept Side-by-side comparison of NSI-189 and Noopept: mechanism, half-life, dose range, safety profile, and vendor pricing. NSI-189 from $84.99 Noopept from $49.99 ## Price snapshot ### NSI-189 Current low $84.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### Noopept Current low $49.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## NSI-189 NSI-189 is a novel synthetic compound developed by Neuralstem Inc. that stimulates neurogenesis in the human hippocampus. Phase 2 trials for major depressive disorder showed improvements in subjective cognitive function,… **Lowest listed price:** $84.99 across 1 listing Full NSI-189 profile (https://www.bodyhackguide.co/compound/nsi-189) ## Noopept Noopept is the common brand and research name for N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111; INN omberacetam), a small dipeptide nootropic developed in the 1990s at the Russian Academy of Medical Sciences'… **Lowest listed price:** $49.99 across 1 listing Full Noopept profile (https://www.bodyhackguide.co/compound/noopept) ## Side-by-side comparison | Attribute | NSI-189 | Noopept | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Preclinical | Preclinical | | Mechanism of Action | NSI-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from BDNF or classical antidepressants. Rodent studies show a 20% increase in hippocampal volume after 6 weeks of treatment. It is not a… | Noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. Several convergent pathways have been proposed, each supported by preclinical data but none definitively established as the primary driver of its… | | Half-Life | — | — | | Typical Dose Range | — | — | | Dosing Frequency | — | — | | Administration | — | — | | Side Effects | Mild GI discomfort, injection site reaction (if injected), headache. Very well-tolerated. Rare: anxiety or insomnia at high doses. | Noopept is generally well tolerated in the Russian clinical literature, with side effects that are typically mild and transient. However, "well tolerated in Russian open-label trials" is a weaker safety claim than the rigorous multi-phase trial data underlying… | | Molecular Weight | 313.36 g/mol | 318.37 g/mol | | Common Vial Sizes | — | — | ## Price tracking Tracking NSI-189 prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price History 2 data points ### NSI-189: potential benefits - Increased hippocampal neurogenesis - Antidepressant effects - Enhanced synaptic plasticity - Improved cognitive function - Long-lasting mood improvement - Potential PTSD treatment ### Noopept: potential benefits - Memory enhancement - BDNF/NGF upregulation - Neuroprotection - Focus and learning speed - Anxiety reduction (moderate) - Anti-amyloid properties ## Frequently asked ### What's the difference between NSI-189 and Noopept? NSI-189 is a nootropics that nsi-189 stimulates proliferation and differentiation of human hippocampal neural stem cells through a mechanism distinct from bdnf or classical antidepressants. rodent studies show…. Noopept is a nootropics that noopept's mechanism of action is multifaceted and — despite decades of research — incompletely understood. several convergent pathways have been proposed, each supported by…. The two differ in mechanism, half-life (not reported vs not reported), and typical dose range. ### Which has the longer half-life, NSI-189 or Noopept? NSI-189 has a half-life of not reported. Noopept has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, NSI-189 or Noopept? Lowest listed price on BodyHackGuide: NSI-189 from $84.99, Noopept from $49.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack NSI-189 and Noopept? Stacking depends on mechanism overlap, safety profile, and goals. NSI-189 and Noopept should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. NSI-189 prices: https://www.bodyhackguide.co/compound/nsi-189?tab=prices Noopept prices: https://www.bodyhackguide.co/compound/noopept?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy NSI-189 or Noopept Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Noopept vs Piracetam: https://www.bodyhackguide.co/compare/noopept-vs-piracetam Dihexa vs Noopept: https://www.bodyhackguide.co/compare/dihexa-vs-noopept **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. 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