--- title: "N-Acetyl-Selank vs Selank: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/n-acetyl-selank-vs-selank description: "Compare N-Acetyl-Selank vs Selank side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # N-Acetyl-Selank vs Selank Side-by-side comparison of N-Acetyl-Selank and Selank: mechanism, half-life, dose range, safety profile, and vendor pricing. N-Acetyl-Selank from $79.99 Selank from $25.00 ## Price snapshot ### N-Acetyl-Selank Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### Selank Current low $25.00 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## N-Acetyl-Selank N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and… **Lowest listed price:** $79.99 across 2 listings Full N-Acetyl-Selank profile (https://www.bodyhackguide.co/compound/n-acetyl-selank) ## Selank Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, 750 Da molecular weight) developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin… **Lowest listed price:** $25.00 across 6 listings Full Selank profile (https://www.bodyhackguide.co/compound/selank) ## Side-by-side comparison | Attribute | N-Acetyl-Selank | Selank | | --- | --- | --- | | Category | Cognitive | Nootropics | | Research Stage | Preclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in Russia | Approved (Russia, as anxiolytic and nootropic medication) | | Mechanism of Action | N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown.… | Primary Mechanism: Multi-System Neurochemical Modulation Selank does not have a single clean receptor-binding mechanism. Unlike benzodiazepines (GABA-A positive allosteric modulators), SSRIs (serotonin reuptake inhibition), or buspirone (5-HT1A partial… | | Half-Life | Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature. | ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation) | | Typical Dose Range | 100-900 mcg | 250-750 mcg intranasal daily (0.15% solution: 2-3 drops per nostril 2-3x daily); typical course is 14-21 days | | Dosing Frequency | Once or twice daily (intranasal); some advanced users split into 2-3 doses | Intranasal 1–3 times daily | | Administration | — | Intranasal | | Side Effects | In short Russian clinical trials, parent Selank was generally well tolerated with no serious adverse effects reported [PMID:18454096]. Reported or plausible effects (largely extrapolated to the analog): mild nasal irritation or congestion from the spray,… | Overall Safety Profile Selank has one of the best safety profiles in the anxiolytic space. Over 15+ years of Russian clinical use and research, the compound has been associated with essentially no serious adverse events at therapeutic doses. This compares… | | Molecular Weight | ~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10. | 751.9 Da | | Common Vial Sizes | — | 5mg, 10mg | ## Price tracking Tracking N-Acetyl-Selank prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price History 5 data points - OF - Half Nattys - Ion Peptide - BHG Labs ### N-Acetyl-Selank: potential benefits - Anxiolytic (calming) effects - the most-studied action of parent Selank, including a Russian clinical trial in generalized anxiety disorder [PMID:18454096] - Nootropic / cognitive support - reported attention and memory benefits in rodent models, linked to BDNF changes [PMID:31625062] - Stress resilience reported without the sedation, tolerance, or dependence typically seen with benzodiazepines (preclinical framing) [PMID:30255741] - Possible support during withdrawal states (alcohol, opioid) in animal models [PMID:24913576][PMID:36322304] - Claimed longer duration vs. plain Selank from N-terminal acetylation - a community/vendor claim not verified in published data ### Selank: potential benefits - Anxiolytic effects comparable to benzodiazepines but without sedation or dependence in Russian clinical trials (PMID: 18454096) - Positive allosteric modulation of brain GABA receptors through a non-benzodiazepine binding site (PMID: 30255741) - Immunomodulation via Th1/Th2 cytokine balance and IL-6 regulation in patients with anxiety-asthenic disorders (PMID: 18577961) - Cognitive and memory support linked to BDNF upregulation in the hippocampus in preclinical models (PMID: 18841804) - Modulation of the endogenous enkephalin-opioid system supporting mood and stress tolerance (PMID: 22550852) - Anti-inflammatory and adaptogenic effects through normalization of stress-induced cytokine dysregulation - Non-addictive anxiolytic profile - no tolerance, withdrawal, or dependence reported across years of Russian clinical use ## Frequently asked ### What's the difference between N-Acetyl-Selank and Selank? N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. The two differ in mechanism, half-life (Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature. vs ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation)), and typical dose range. ### Which has the longer half-life, N-Acetyl-Selank or Selank? N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, N-Acetyl-Selank or Selank? Lowest listed price on BodyHackGuide: N-Acetyl-Selank from $79.99, Selank from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack N-Acetyl-Selank and Selank? Stacking depends on mechanism overlap, safety profile, and goals. N-Acetyl-Selank and Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. N-Acetyl-Selank prices: https://www.bodyhackguide.co/compound/n-acetyl-selank?tab=prices Selank prices: https://www.bodyhackguide.co/compound/selank?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy N-Acetyl-Selank or Selank Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Selank vs Semax: https://www.bodyhackguide.co/compare/selank-vs-semax N Acetyl Selank vs N Acetyl Semax: https://www.bodyhackguide.co/compare/n-acetyl-selank-vs-n-acetyl-semax Selank vs Phenibut: https://www.bodyhackguide.co/compare/selank-vs-phenibut **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). 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All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "N-Acetyl-Selank vs Selank" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "N-Acetyl-Selank vs Selank: Side-by-Side Comparison (2026)", "description": "Compare N-Acetyl-Selank vs Selank side by side. We earn a commission on some vendor links. 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Selank is a nootropics that primary mechanism: multi-system neurochemical modulation selank does not have a single clean receptor-binding mechanism. unlike benzodiazepines (gaba-a positive allosteric…. The two differ in mechanism, half-life (Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. 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Selank has a half-life of ~2-3 minutes plasma half-life (functional anxiolytic and nootropic effects persist 12-24 hours due to gene expression and neurotransmitter modulation). Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, N-Acetyl-Selank or Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Lowest listed price on BodyHackGuide: N-Acetyl-Selank from $79.99, Selank from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack N-Acetyl-Selank and Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. N-Acetyl-Selank and Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. 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