--- title: "MOTS-c vs SS-31: Side-by-Side Comparison (2026)" description: "Compare MOTS-c vs SS-31 — mechanism, half-life, dose range, side effects, and live vendor pricing. MOTS-c from $38.00. SS-31 from $45.00. Side-by-side data from" lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "MOTS-c vs SS-31" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "MOTS-c vs SS-31: Side-by-Side Comparison (2026)", "description": "Compare MOTS-c vs SS-31 — mechanism, half-life, dose range, side effects, and live vendor pricing. MOTS-c from $38.00. SS-31 from $45.00. 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SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. The two differ in mechanism, half-life (~4–6 hours vs ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, MOTS-c or SS-31?", "acceptedAnswer": { "@type": "Answer", "text": "MOTS-c has a half-life of ~4–6 hours. SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, MOTS-c or SS-31?", "acceptedAnswer": { "@type": "Answer", "text": "Current lowest live price on BodyHackGuide: MOTS-c from $38.00, SS-31 from $45.00. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack MOTS-c and SS-31?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. MOTS-c and SS-31 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompare%2Fmots-c-vs-ss-31) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 2. [Compare](/compare) 3. MOTS-c vs SS-31 # MOTS-c vs SS-31 Side-by-side comparison of MOTS-c and SS-31: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land. MOTS-c from $38.00 SS-31 from $45.00 ## Live price snapshot ### MOTS-c Current low $44.99 as of Sep 5, 2026 7-day low $44.99 30-day low $44.99 30-day change — baseline building ### SS-31 Current low $89.99 as of Sep 5, 2026 7-day low $72.00 30-day low $72.00 30-day change — baseline building ## MOTS-c MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It… **Live lowest price:** $38.00 across 8 vendors [Full MOTS-c profile](/compound/mots-c) ## SS-31 Featured SS-31 (elamipretide; MTP-131; formerly Bendavia; chemical sequence D-Arg-Dmt-Lys-Phe-NH2 with dimethyltyrosine at position 2) is a first-in-class aromatic-cationic tetrapeptide designed to selectively target the inner… **Live lowest price:** $45.00 across 5 vendors [Full SS-31 profile](/compound/ss-31) ## Side-by-side comparison Attribute MOTS-c SS-31 Category Longevity & Cellular Health Mitochondrial Peptides Research Stage Preclinical Clinical/Approved Mechanism of Action A New Class of Signaling Molecule MOTS-c belongs to the mitochondrial-derived peptides (MDPs) - a class of small peptides encoded within mitochondrial DNA open reading frames that were historically thought to encode only ribosomal RNAs. The known MDPs include:… SS-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high concentration of cardiolipin, a signature mitochondrial anionic phospholipid - to… Half-Life ~4–6 hours ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding Typical Dose Range 5,000–10,000 mcg (5–10 mg) per injection 20000-60000 Dosing Frequency 2-3 times per week Once daily subcutaneous (some protocols use 5-6 days per week) Administration Subcutaneous, Intramuscular — Side Effects Reported Effects (limited human data) - Injection site reactions — Mild erythema, transient itching at SC injection site. Site rotation minimizes. Probably the single most reported issue. - Transient fatigue — Some users report mild fatigue in the first week… SS-31 (elamipretide) has been generally well-tolerated across clinical trials spanning over a decade of human exposure, with adverse event profiles dominated by injection site reactions rather than systemic toxicity. This favorable safety profile reflects both… Molecular Weight 2174 Da 639.8 g/mol Common Vial Sizes 5mg, 10mg — ## Price History 6 data points - OF - BM - Unknown - VANDL Labs - Unknown - Ion Peptide - Disguised Alpha ## Price History 3 data points - Ion Peptide - BHG Labs - Disguised Alpha ### MOTS-c — potential benefits - Insulin sensitivity - Exercise mimicry - Metabolic health - Anti-aging - Fat oxidation - Longevity ### SS-31 — potential benefits - No structured benefit list published. ## Frequently asked ### What's the difference between MOTS-c and SS-31? MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. The two differ in mechanism, half-life (~4–6 hours vs ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding), and typical dose range. ### Which has the longer half-life, MOTS-c or SS-31? MOTS-c has a half-life of ~4–6 hours. SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, MOTS-c or SS-31? Current lowest live price on BodyHackGuide: MOTS-c from $38.00, SS-31 from $45.00. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers. ### Can you stack MOTS-c and SS-31? Stacking depends on mechanism overlap, safety profile, and goals. MOTS-c and SS-31 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Live listings from the vendors we track, refreshed continuously. [MOTS-c prices](/compound/mots-c?tab=prices) [SS-31 prices](/compound/ss-31?tab=prices) [Compare all compounds](/compare) ### Before you buy MOTS-c or SS-31 Check the vendor trust score. Every supplier we track is rated 0–100 on COA verification, payment transparency, shipping, reviews, and listings — one published, reproducible methodology, applied to every vendor including BHG Labs, which shares our ownership. [View Vendor Scorecard](/vendors/scorecard) ## Related comparisons [Methylene Blue vs MOTS C](/compare/methylene-blue-vs-mots-c)[MOTS C vs NMN](/compare/mots-c-vs-nmn)[NMN vs NAD](/compare/nmn-vs-nad)[Pinealon vs Epithalon](/compare/pinealon-vs-epithalon)[COQ10 vs NMN](/compare/coq10-vs-nmn)[Urolithin A vs NMN](/compare/urolithin-a-vs-nmn)[Metformin vs Rapamycin](/compare/metformin-vs-rapamycin)[Astaxanthin vs COQ10](/compare/astaxanthin-vs-coq10) **Research use only.** BodyHackGuide is a research and price-comparison reference. BodyHackGuide and BHG Labs share common ownership. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. 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