--- title: "Lion's Mane Mushroom vs PE-22-28: Compared (2026)" url: https://www.bodyhackguide.co/compare/lions-mane-vs-pe-22-28 description: "Compare Lion's Mane Mushroom vs PE-22-28 side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Lion's Mane Mushroom vs PE-22-28 Side-by-side comparison of Lion's Mane Mushroom and PE-22-28: mechanism, half-life, dose range, safety profile, and vendor pricing. Lion's Mane Mushroom: no price on file PE-22-28 from $49.99 ## Price snapshot ### Lion's Mane Mushroom Current low — 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### PE-22-28 Current low $49.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Lion's Mane Mushroom Lion's Mane (scientific name Hericium erinaceus; also known as yamabushitake in Japanese, houtou in Chinese, bearded tooth fungus, monkey head mushroom, and pom pom mushroom) is a white-to-cream coloured edible and… No vendor price on file. Full Lion's Mane Mushroom profile (https://www.bodyhackguide.co/compound/lions-mane) ## PE-22-28 PE-22-28 is a synthetic seven-amino-acid peptide (sequence PAGASRLLLLTGEIDLP derivative, commonly truncated to PE-22-28 as shorthand for "position 22-28" within the parent humanin-family sequence) that was designed as an… **Lowest listed price:** $49.99 across 1 listing Full PE-22-28 profile (https://www.bodyhackguide.co/compound/pe-22-28) ## Side-by-side comparison | Attribute | Lion's Mane Mushroom | PE-22-28 | | --- | --- | --- | | Category | Nootropics | Nootropics | | Research Stage | Preclinical | Preclinical | | Mechanism of Action | Lion's Mane's proposed mechanism of action centres on stimulation of endogenous neurotrophic factor synthesis, particularly nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), with additional proposed effects on anti-inflammatory pathways,… | PE-22-28 is a synthetic 7-amino-acid peptide (sequence GVSWGLR) and a shortened analog of spadin. Its proposed mechanism is inhibition of the TREK-1 (TWIK-related K+) channel, a two-pore-domain potassium channel (K2P2.1 / KCNK2) implicated in mood regulation.… | | Half-Life | — | Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242]. | | Typical Dose Range | — | 250-2000 mcg subcutaneous per dose (empirical research-chemical community range; no clinically validated human dose exists; effective preclinical rodent doses were far lower, ~3 mcg/kg). | | Dosing Frequency | — | Once daily or every other day (research-chemical community protocols; no validated clinical dosing schedule). | | Administration | — | — | | Side Effects | Lion's Mane has one of the best safety profiles in the nootropic and medicinal supplement space. It has been consumed as food for centuries in East Asia, and modern supplemental use at typical doses has been well tolerated in clinical trials of up to 16 weeks… | No human side-effect data exist for PE-22-28 because it has never been tested in people. What can be said comes from rodent studies of PE-22-28, spadin and their analogs, plus general considerations for injected research peptides. In the preclinical work, the… | | Molecular Weight | N/A | 773.9 g/mol | | Common Vial Sizes | — | — | ## Price History 2 data points ### Lion's Mane Mushroom: potential benefits - NGF stimulation - Neurogenesis - Memory improvement - Nerve repair - Anxiety reduction - Depression improvement ### PE-22-28: potential benefits - Antidepressant-like effects in rodent models of depression (preclinical only) - Potent, selective inhibition of the TREK-1 (K2P2.1) potassium channel (IC50 ~0.12 nM) - Rapid-onset (~4-day) antidepressant profile in animals, unlike the multi-week lag of SSRIs - Increased hippocampal neurogenesis in mice - Increased cortical synaptogenesis (PSD-95) and BDNF expression in preclinical studies - No human-validated benefits; not approved for any use (research use only) ## Frequently asked ### What's the difference between Lion's Mane Mushroom and PE-22-28? Lion's Mane Mushroom is a nootropics that lion's mane's proposed mechanism of action centres on stimulation of endogenous neurotrophic factor synthesis, particularly nerve growth factor (ngf) and brain-derived neurotrophic…. PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range. ### Which has the longer half-life, Lion's Mane Mushroom or PE-22-28? Lion's Mane Mushroom has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Can you stack Lion's Mane Mushroom and PE-22-28? Stacking depends on mechanism overlap, safety profile, and goals. Lion's Mane Mushroom and PE-22-28 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Lion's Mane Mushroom prices: https://www.bodyhackguide.co/compound/lions-mane?tab=prices PE-22-28 prices: https://www.bodyhackguide.co/compound/pe-22-28?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Lion's Mane Mushroom or PE-22-28 Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Cordyceps vs Lions Mane: https://www.bodyhackguide.co/compare/cordyceps-vs-lions-mane **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Lion's Mane Mushroom vs PE-22-28" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "Lion's Mane Mushroom vs PE-22-28: Compared (2026)", "description": "Compare Lion's Mane Mushroom vs PE-22-28 side by side. We earn a commission on some vendor links. 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PE-22-28 is a nootropics that pe-22-28 is a synthetic 7-amino-acid peptide (sequence gvswglr) and a shortened analog of spadin. its proposed mechanism is inhibition of the trek-1 (twik-related k+) channel, a…. The two differ in mechanism, half-life (not reported vs Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, Lion's Mane Mushroom or PE-22-28?", "acceptedAnswer": { "@type": "Answer", "text": "Lion's Mane Mushroom has a half-life of not reported. PE-22-28 has a half-life of Not characterized in humans. As a small 7-amino-acid peptide a short plasma half-life is expected; in mice the parent peptide spadin lost antidepressant activity by about 7 hours after a single dose, while modified analogs (e.g., G/A-PE 22-28) extended the behavioral effect to roughly 21-23 hours [PMID:28955242].. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Can you stack Lion's Mane Mushroom and PE-22-28?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. Lion's Mane Mushroom and PE-22-28 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] ```