--- title: "IGF-1 LR3 vs ARA-290: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/igf-1-lr3-vs-ara-290 description: "Compare IGF-1 LR3 vs ARA-290 side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # IGF-1 LR3 vs ARA-290 Side-by-side comparison of IGF-1 LR3 and ARA-290: mechanism, half-life, dose range, safety profile, and vendor pricing. IGF-1 LR3 from $49.99 ARA-290 from $32.00 ## Price snapshot ### IGF-1 LR3 Current low $49.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### ARA-290 Current low $32.00 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## IGF-1 LR3 IGF-1 LR3 (Long R3 IGF-1) is a synthetic analog of human insulin-like growth factor 1 modified at two positions to dramatically extend its serum half-life and amplify its tissue bioactivity compared to native IGF-1. The… **Lowest listed price:** $49.99 across 4 listings Full IGF-1 LR3 profile (https://www.bodyhackguide.co/compound/igf-1-lr3) ## ARA-290 ARA-290, also known as Cibinetide or pHBSP (Helix B Surface Peptide), is an 11-amino-acid peptide — QEQLERALNSS — designed to mimic a specific region of the tissue-protective surface of erythropoietin (EPO) without… **Lowest listed price:** $32.00 across 5 listings Full ARA-290 profile (https://www.bodyhackguide.co/compound/ara-290) ## Side-by-side comparison | Attribute | IGF-1 LR3 | ARA-290 | | --- | --- | --- | | Category | Growth Hormone / IGF-1 Axis | Recovery | | Research Stage | Preclinical | Phase 2 | | Mechanism of Action | IGF-1 Receptor Signaling IGF-1 LR3 binds the IGF-1 receptor (IGF1R) - a transmembrane receptor tyrosine kinase expressed on virtually every cell type in the human body. IGF1R activation triggers two principal intracellular signaling cascades: PI3K / Akt / mTOR… | ARA-290's mechanism of action is one of the more elegantly engineered examples of pharmaceutical design in the peptide space. Understanding it requires appreciation of the dual-receptor biology of erythropoietin and the specific receptor-selective engineering… | | Half-Life | 20-30 hours (community/vendor estimate; no published human PK study of IGF-1 LR3) vs ~12 minutes for native IGF-1 | ~2 minutes (plasma half-life; downstream tissue-protective effects persist hours to days) | | Typical Dose Range | 20-80 mcg per day | 1 mg - 4 mg subcutaneous daily | | Dosing Frequency | Once daily, typically post-workout or in the morning | Once daily | | Administration | Subcutaneous, Intramuscular | — | | Side Effects | Acute and Common - Hypoglycemia — The primary acute safety concern. Post-injection blood glucose drops can produce shakiness, sweating, confusion, palpitations, and in severe cases loss of consciousness. Mitigation: 30-40g of fast-digesting carbohydrate within… | ARA-290 has demonstrated a notably favorable safety profile across clinical trials — one of the cleaner safety records among research peptides. The engineering rationale of separating tissue-protective effects from hematopoietic effects appears to have largely… | | Molecular Weight | 9117 Da | ~1257 Da | | Common Vial Sizes | 100mcg, 1mg | — | ## Price History 3 data points - Half Nattys - Ion Peptide - Disguised Alpha ## Price History 3 data points - Ion Peptide - BHG Labs - LB ### IGF-1 LR3: potential benefits - Muscle hypertrophy - Recovery - Protein synthesis - Fat metabolism - Glucose uptake ### ARA-290: potential benefits - Neuroprotective effects - Anti-inflammatory activity - Tissue repair without erythropoiesis - Potential diabetic neuropathy treatment - Sarcoidosis symptom reduction ## Frequently asked ### What's the difference between IGF-1 LR3 and ARA-290? IGF-1 LR3 is a growth hormone / igf-1 axis that igf-1 receptor signaling igf-1 lr3 binds the igf-1 receptor (igf1r) - a transmembrane receptor tyrosine kinase expressed on virtually every cell type in the human body. igf1r…. ARA-290 is a recovery that ara-290's mechanism of action is one of the more elegantly engineered examples of pharmaceutical design in the peptide space. understanding it requires appreciation of the…. The two differ in mechanism, half-life (20-30 hours (community/vendor estimate; no published human PK study of IGF-1 LR3) vs ~12 minutes for native IGF-1 vs ~2 minutes (plasma half-life; downstream tissue-protective effects persist hours to days)), and typical dose range. ### Which has the longer half-life, IGF-1 LR3 or ARA-290? IGF-1 LR3 has a half-life of 20-30 hours (community/vendor estimate; no published human PK study of IGF-1 LR3) vs ~12 minutes for native IGF-1. ARA-290 has a half-life of ~2 minutes (plasma half-life; downstream tissue-protective effects persist hours to days). Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, IGF-1 LR3 or ARA-290? Lowest listed price on BodyHackGuide: IGF-1 LR3 from $49.99, ARA-290 from $32.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack IGF-1 LR3 and ARA-290? Stacking depends on mechanism overlap, safety profile, and goals. IGF-1 LR3 and ARA-290 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. IGF-1 LR3 prices: https://www.bodyhackguide.co/compound/igf-1-lr3?tab=prices ARA-290 prices: https://www.bodyhackguide.co/compound/ara-290?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy IGF-1 LR3 or ARA-290 Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons IGF-1-LR3 vs Ipamorelin: https://www.bodyhackguide.co/compare/igf-1-lr3-vs-ipamorelin **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "IGF-1 LR3 vs ARA-290" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "IGF-1 LR3 vs ARA-290: Side-by-Side Comparison (2026)", "description": "Compare IGF-1 LR3 vs ARA-290 side by side. We earn a commission on some vendor links. 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