--- title: "Dihexa vs N-Acetyl-Selank: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/dihexa-vs-n-acetyl-selank description: "Compare Dihexa vs N-Acetyl-Selank side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Dihexa vs N-Acetyl-Selank Side-by-side comparison of Dihexa and N-Acetyl-Selank: mechanism, half-life, dose range, safety profile, and vendor pricing. Dihexa from $79.99 N-Acetyl-Selank from $79.99 ## Price snapshot ### Dihexa Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### N-Acetyl-Selank Current low $79.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Dihexa Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models… **Lowest listed price:** $79.99 across 3 listings Full Dihexa profile (https://www.bodyhackguide.co/compound/dihexa) ## N-Acetyl-Selank N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and… **Lowest listed price:** $79.99 across 2 listings Full N-Acetyl-Selank profile (https://www.bodyhackguide.co/compound/n-acetyl-selank) ## Side-by-side comparison | Attribute | Dihexa | N-Acetyl-Selank | | --- | --- | --- | | Category | Nootropics | Cognitive | | Research Stage | Preclinical | Preclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in Russia | | Mechanism of Action | Dihexa is a small-molecule analog derived from angiotensin IV (AngIV). It retains the Tyr-Ile core of Nle1-AngIV, with an N-terminal hexanoic acid cap and a C-terminal 6-aminohexanoic amide that give it metabolic stability and blood-brain-barrier penetration.… | N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown.… | | Half-Life | Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. | Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature. | | Typical Dose Range | 5 to 40 mg oral per day (anecdotal range; no established human dose) | 100-900 mcg | | Dosing Frequency | Once daily (oral), typically in the morning | Once or twice daily (intranasal); some advanced users split into 2-3 doses | | Administration | Oral, Intranasal, Subcutaneous | — | | Side Effects | No controlled human safety data. Anecdotal user reports include headache, fatigue, irritability or anxiety, insomnia, and vivid dreams, usually at higher doses. The most serious concern is theoretical rather than reported: because dihexa acts on the HGF/c-Met… | In short Russian clinical trials, parent Selank was generally well tolerated with no serious adverse effects reported [PMID:18454096]. Reported or plausible effects (largely extrapolated to the analog): mild nasal irritation or congestion from the spray,… | | Molecular Weight | 504.7 g/mol | ~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10. | | Common Vial Sizes | 50mg, 100mg | — | ## Price History 2 data points ## Price tracking Tracking N-Acetyl-Selank prices since September 5, 2026. Trend chart unlocks once we have price snapshots from more than one day. ### Dihexa: potential benefits - Synaptogenesis: formation of new dendritic spines and functional synapses (preclinical) - Memory and spatial-learning support in rodent models - Potential research application in Alzheimer's and other neurodegenerative disease models - HGF/c-Met and PI3K/Akt-linked neuroplasticity (mechanism proposed; key paper retracted) ### N-Acetyl-Selank: potential benefits - Anxiolytic (calming) effects - the most-studied action of parent Selank, including a Russian clinical trial in generalized anxiety disorder [PMID:18454096] - Nootropic / cognitive support - reported attention and memory benefits in rodent models, linked to BDNF changes [PMID:31625062] - Stress resilience reported without the sedation, tolerance, or dependence typically seen with benzodiazepines (preclinical framing) [PMID:30255741] - Possible support during withdrawal states (alcohol, opioid) in animal models [PMID:24913576][PMID:36322304] - Claimed longer duration vs. plain Selank from N-terminal acetylation - a community/vendor claim not verified in published data ## Frequently asked ### What's the difference between Dihexa and N-Acetyl-Selank? Dihexa is a nootropics that dihexa is a small-molecule analog derived from angiotensin iv (angiv). it retains the tyr-ile core of nle1-angiv, with an n-terminal hexanoic acid cap and a c-terminal…. N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range. ### Which has the longer half-life, Dihexa or N-Acetyl-Selank? Dihexa has a half-life of Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Dihexa or N-Acetyl-Selank? Lowest listed price on BodyHackGuide: Dihexa from $79.99, N-Acetyl-Selank from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack Dihexa and N-Acetyl-Selank? Stacking depends on mechanism overlap, safety profile, and goals. Dihexa and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Dihexa prices: https://www.bodyhackguide.co/compound/dihexa?tab=prices N-Acetyl-Selank prices: https://www.bodyhackguide.co/compound/n-acetyl-selank?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Dihexa or N-Acetyl-Selank Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons N Acetyl Selank vs N Acetyl Semax: https://www.bodyhackguide.co/compare/n-acetyl-selank-vs-n-acetyl-semax Dihexa vs Noopept: https://www.bodyhackguide.co/compare/dihexa-vs-noopept **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. All rights reserved. - Terms: https://www.bodyhackguide.co/terms - Privacy: https://www.bodyhackguide.co/privacy ## Structured data ```json [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Dihexa vs N-Acetyl-Selank" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "Dihexa vs N-Acetyl-Selank: Side-by-Side Comparison (2026)", "description": "Compare Dihexa vs N-Acetyl-Selank side by side. We earn a commission on some vendor links. 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N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence. vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, Dihexa or N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Dihexa has a half-life of Not characterized in humans. Dihexa was engineered for metabolic stability (resistant to plasma and enzymatic degradation) and blood-brain-barrier penetration; in preclinical work its central procognitive effects appear to outlast its plasma presence.. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, Dihexa or N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Lowest listed price on BodyHackGuide: Dihexa from $79.99, N-Acetyl-Selank from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack Dihexa and N-Acetyl-Selank?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. Dihexa and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] ```