--- title: "Cortagen vs Pinealon: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/cortagen-vs-pinealon description: "Compare Cortagen vs Pinealon side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Cortagen vs Pinealon Side-by-side comparison of Cortagen and Pinealon: mechanism, half-life, dose range, safety profile, and vendor pricing. Cortagen from $79.00 Pinealon from $45.00 ## Price snapshot ### Cortagen Current low $79.00 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### Pinealon Current low $45.00 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Cortagen Cortagen is a synthetic tetrapeptide, Ala-Glu-Asp-Pro (AEDP), made at Vladimir Khavinson's St. Petersburg Institute of Bioregulation and Gerontology from the amino acid analysis of Cortexin, a peptide preparation from… **Lowest listed price:** $79.00 across 1 listing Full Cortagen profile (https://www.bodyhackguide.co/compound/cortagen) ## Pinealon Pinealon is a synthetic tripeptide — glutamyl-aspartyl-arginine (Glu-Asp-Arg, or EDR) — developed by the St Petersburg Institute of Bioregulation and Gerontology (IBG) under the leadership of Professor Vladimir… **Lowest listed price:** $45.00 across 3 listings Full Pinealon profile (https://www.bodyhackguide.co/compound/pinealon) ## Side-by-side comparison | Attribute | Cortagen | Pinealon | | --- | --- | --- | | Category | Longevity | Nootropics | | Research Stage | Preclinical | Preclinical | | Mechanism of Action | Cortagen is a synthetic tetrapeptide, Ala-Glu-Asp-Pro (AEDP), created by the Khavinson group through directed synthesis based on the amino-acid composition of Cortexin, a polypeptide complex extracted from the cerebral cortex [PMID:15159690]. It is a… | The proposed mechanism of Pinealon is rooted in the Khavinson school's broader theory of short-peptide tissue-specific bioregulation. The full theory is worth understanding because it underlies all twelve Russian bioregulator compounds in this catalog. The… | | Half-Life | Unknown (tetrapeptide; estimated <4 hours) | Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing. | | Typical Dose Range | — | Subcutaneous (primary route): 2-10 mg/day, typically 3-5 mg, in pulsed 10-20 day cycles, 2-4 cycles/year. Intranasal: 150-800 mcg per nostril daily. Research use only; oral dosing is not recommended because the peptide is largely degraded by GI proteases. | | Dosing Frequency | once_daily | Once daily during a cycle (morning preferred); some advanced users split into AM + midday doses. Not dosed continuously year-round - cycles are pulsed. | | Administration | Subcutaneous, Intramuscular | — | | Side Effects | — | The side-effect profile of Pinealon, based on the available Russian clinical literature and user-reported experience, is described as mild and uncommon. Whether this reflects genuinely low toxicity or inadequate reporting in the available studies is a… | | Molecular Weight | 430.4 g/mol (C17H26N4O9, PubChem CID 18439621) | 418.40 g/mol (C15H26N6O8) | | Common Vial Sizes | 20 | — | ## Price tracking Tracking Cortagen prices since April 22, 2026. Trend chart unlocks once we have price snapshots from more than one day. ## Price History 2 data points - Ion Peptide - Disguised Alpha ### Cortagen: potential benefits - Peripheral nerve repair - accelerated axon regeneration and faster nerve-conduction recovery after injury in rat models [PMID:11276314; PMID:12134478] - Neuroprotection and antioxidant activity in the cerebral cortex and in chronic brain-ischemia models (preclinical) [PMID:18239817; PMID:21476278] - CNS/cognitive support as the synthetic short-peptide analog of the cortex-derived Russian drug Cortexin - Anti-aging chromatin remodeling - reactivation of age-silenced ribosomal genes in lymphocytes from elderly donors [PMID:15085253; PMID:37042594] - Mild immune-signaling modulation (IL-2 expression), generally weaker than Vilon or Epithalon [PMID:12447482; PMID:16224591] - Longevity-protocol stacking as one of the Khavinson short-peptide bioregulators (commonly paired with Epitalon or Pinealon) ### Pinealon: potential benefits - Neuroprotection against oxidative and hypoxic stress (preclinical models) - Antioxidant support - reduced oxidative DNA damage in aged neurons (in vitro) - Cognitive and memory support in aging populations (small Russian clinical reports) - Reduced neuronal apoptosis and support of dendritic-tree integrity in cell models - Investigated for neuroprotection in Alzheimer's-model systems (preclinical) ## Frequently asked ### What's the difference between Cortagen and Pinealon? Cortagen is a longevity that cortagen is a synthetic tetrapeptide, ala-glu-asp-pro (aedp), created by the khavinson group through directed synthesis based on the amino-acid composition of cortexin, a…. Pinealon is a nootropics that the proposed mechanism of pinealon is rooted in the khavinson school's broader theory of short-peptide tissue-specific bioregulation. the full theory is worth understanding because…. The two differ in mechanism, half-life (Unknown (tetrapeptide; estimated <4 hours) vs Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.), and typical dose range. ### Which has the longer half-life, Cortagen or Pinealon? Cortagen has a half-life of Unknown (tetrapeptide; estimated <4 hours). Pinealon has a half-life of Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, Cortagen or Pinealon? Lowest listed price on BodyHackGuide: Cortagen from $79.00, Pinealon from $45.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack Cortagen and Pinealon? Stacking depends on mechanism overlap, safety profile, and goals. Cortagen and Pinealon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Cortagen prices: https://www.bodyhackguide.co/compound/cortagen?tab=prices Pinealon prices: https://www.bodyhackguide.co/compound/pinealon?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Cortagen or Pinealon Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons Pinealon vs Epithalon: https://www.bodyhackguide.co/compare/pinealon-vs-epithalon **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). BodyHackGuide (https://www.bodyhackguide.co/) Your biohacking research hub: compound pricing, brain health protocols, dosing tools, and vendor reviews. support@bodyhackguide.co Join our Discord: https://discord.gg/Mhq5UdRYBA r/BodyHackGuide on Reddit: https://reddit.com/r/BodyHackGuide **Affiliate Disclosure:** We rank every vendor on the same public, reproducible methodology (https://www.bodyhackguide.co/vendors/methodology). Full details in our affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). **Research Disclaimer:** All compounds listed are for laboratory and research purposes only. Not for human consumption. This site does not sell or ship any products. Always consult a qualified healthcare professional and comply with local regulations. © 2026 BodyHackGuide. 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