--- title: "Cardiogen vs NAD+: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/cardiogen-vs-nad description: "Compare Cardiogen vs NAD+ side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices. NAD+ from $25.00." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Cardiogen vs NAD+ Side-by-side comparison of Cardiogen and NAD+: mechanism, half-life, dose range, safety profile, and vendor pricing. Cardiogen: no price on file NAD+ from $25.00 ## Price snapshot ### Cardiogen Current low — 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### NAD+ Current low $25.00 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Cardiogen Cardiogen is a short synthetic peptide developed in Russia by Vladimir Khavinson and his collaborators at the St. Petersburg Institute of Bioregulation and Gerontology, positioned as a "myocardial bioregulator" intended… No vendor price on file. Full Cardiogen profile (https://www.bodyhackguide.co/compound/cardiogen) ## NAD+ NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.… **Lowest listed price:** $25.00 across 11 listings Full NAD+ profile (https://www.bodyhackguide.co/compound/nad) ## Side-by-side comparison | Attribute | Cardiogen | NAD+ | | --- | --- | --- | | Category | Recovery | Longevity | | Research Stage | Preclinical | Phase II | | Mechanism of Action | Mechanism of Action Cardiogen's proposed mechanism is the Khavinson short-peptide bioregulator framework applied to cardiac tissue. The three-stage model - absorption and distribution, nuclear import, sequence-selective chromatin modulation - has been detailed… | Redox Cofactor Function NAD+ serves as the primary electron acceptor in catabolic reactions (glycolysis, TCA cycle, fatty acid oxidation), cycling between its oxidized (NAD+) and reduced (NADH) forms. This fundamental energy metabolism role means every cell… | | Half-Life | Not characterized in humans. As a short linear tetrapeptide (Ala-Glu-Asp-Arg), Cardiogen is expected to undergo rapid enzymatic hydrolysis to its constituent amino acids; no validated modern pharmacokinetic half-life has been published. | Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent | | Typical Dose Range | 20 mg oral once daily x10 days, or 2-5 mg SC daily x10 days; 60-90 day washout | Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. | | Dosing Frequency | — | Oral precursors once daily (higher doses split AM/midday); IV NAD+ weekly-to-monthly at clinics. | | Administration | — | Oral (precursors), Intravenous, Intramuscular, Subcutaneous | | Side Effects | Side Effects and Safety Cardiogen has been used in Russian clinical settings and post-Soviet supplement channels for roughly 20 years without a substantial adverse-event literature. That absence is reassuring in direction but must be contextualised against the… | Nicotinamide Riboside (NR) NR has the best-characterized safety profile of the NAD+ precursors. Across published RCTs at 1,000-2,000 mg/day for up to 12 weeks, adverse effects have been mild and uncommon: - Gastrointestinal upset (5-10% of users) - Mild… | | Molecular Weight | 489.5 g/mol (C18H31N7O9, tetrapeptide Ala-Glu-Asp-Arg) | 663.4 g/mol (NAD+); NR 255.3 g/mol; NMN 334.2 g/mol; NAM 122.1 g/mol | | Common Vial Sizes | — | 100mg, 250mg, 500mg | ## Price History 4 data points - OF - BM - Half Nattys - Ion Peptide - BHG Labs ### Cardiogen: potential benefits - Cardiovascular tissue support - Cardiac muscle repair - Improved heart function markers - Anti-aging effects on heart tissue ### NAD+: potential benefits - Restores age-associated NAD+ decline — 50% loss between young and older adulthood - Increases peripheral blood NAD+ by up to 142% at 1,000 mg NR daily (Elhassan 2019) - Supports sirtuin-mediated gene regulation and PARP-mediated DNA repair - Improves muscle insulin sensitivity in prediabetic postmenopausal women (Yoshino 2021) - Increases aerobic performance in amateur runners at 300-600 mg NMN (Liao 2021) - Reduces inflammatory cytokines (IL-6, TNF-alpha) in middle-aged/elderly (Martens, Elhassan) - Brain NAD+ elevation demonstrated in Parkinson trial (Brakedal 2022) - Excellent safety profile at evidence-supported doses (500-2000 mg/day NR) ## Frequently asked ### What's the difference between Cardiogen and NAD+? Cardiogen is a recovery that mechanism of action cardiogen's proposed mechanism is the khavinson short-peptide bioregulator framework applied to cardiac tissue. the three-stage model - absorption and…. NAD+ is a longevity that redox cofactor function nad+ serves as the primary electron acceptor in catabolic reactions (glycolysis, tca cycle, fatty acid oxidation), cycling between its oxidized (nad+) and…. The two differ in mechanism, half-life (Not characterized in humans. As a short linear tetrapeptide (Ala-Glu-Asp-Arg), Cardiogen is expected to undergo rapid enzymatic hydrolysis to its constituent amino acids; no validated modern pharmacokinetic half-life has been published. vs Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent), and typical dose range. ### Which has the longer half-life, Cardiogen or NAD+? Cardiogen has a half-life of Not characterized in humans. As a short linear tetrapeptide (Ala-Glu-Asp-Arg), Cardiogen is expected to undergo rapid enzymatic hydrolysis to its constituent amino acids; no validated modern pharmacokinetic half-life has been published.. NAD+ has a half-life of Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Can you stack Cardiogen and NAD+? Stacking depends on mechanism overlap, safety profile, and goals. Cardiogen and NAD+ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Cardiogen prices: https://www.bodyhackguide.co/compound/cardiogen?tab=prices NAD+ prices: https://www.bodyhackguide.co/compound/nad?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Cardiogen or NAD+ Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons NMN vs NAD: https://www.bodyhackguide.co/compare/nmn-vs-nad **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. 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