--- title: "Astragalus vs MOTS-c: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/astragalus-vs-mots-c description: "Compare Astragalus vs MOTS-c side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # Astragalus (Huang Qi) vs MOTS-c Side-by-side comparison of Astragalus (Huang Qi) and MOTS-c: mechanism, half-life, dose range, safety profile, and vendor pricing. Astragalus (Huang Qi): no price on file MOTS-c from $44.99 ## Price snapshot ### Astragalus (Huang Qi) Current low — 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### MOTS-c Current low $44.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## Astragalus (Huang Qi) Astragalus (scientific name Astragalus membranaceus, also classified as Astragalus mongholicus or Astragalus propinquus; called Huang Qi / Θ╗äΦè¬ in Mandarin Chinese — literally "yellow leader" referring to the yellow… No vendor price on file. Full Astragalus (Huang Qi) profile (https://www.bodyhackguide.co/compound/astragalus) ## MOTS-c MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It… **Lowest listed price:** $44.99 across 9 listings Full MOTS-c profile (https://www.bodyhackguide.co/compound/mots-c) ## Side-by-side comparison | Attribute | Astragalus (Huang Qi) | MOTS-c | | --- | --- | --- | | Category | Adaptogen | Longevity & Cellular Health | | Research Stage | Preclinical | Preclinical | | Mechanism of Action | Astragalus (Astragalus membranaceus) operates through multiple pharmacologic mechanisms reflecting its complex phytochemistry. The major active fractions — astragalus polysaccharides (APS), astragalosides (particularly astragaloside IV), cycloastragenol, and… | A New Class of Signaling Molecule MOTS-c belongs to the mitochondrial-derived peptides (MDPs) - a class of small peptides encoded within mitochondrial DNA open reading frames that were historically thought to encode only ribosomal RNAs. The known MDPs include:… | | Half-Life | — | ~4–6 hours | | Typical Dose Range | — | 5,000–10,000 mcg (5–10 mg) per injection | | Dosing Frequency | — | 2-3 times per week | | Administration | — | Subcutaneous, Intramuscular | | Side Effects | Safety is generally excellent — consistent with astragalus's "superior grade" classical TCM classification and millennia of widespread medicinal and culinary use. Adverse effects at typical doses of quality preparations are uncommon and usually mild. Key… | Reported Effects (limited human data) - Injection site reactions — Mild erythema, transient itching at SC injection site. Site rotation minimizes. Probably the single most reported issue. - Transient fatigue — Some users report mild fatigue in the first week… | | Molecular Weight | — | 2174 Da | | Common Vial Sizes | — | 5mg, 10mg | ## Price History 5 data points - OF - BM - Half Nattys - Ion Peptide - Disguised Alpha - BHG Labs ### Astragalus (Huang Qi): potential benefits - No structured benefit list published. ### MOTS-c: potential benefits - Insulin sensitivity - Exercise mimicry - Metabolic health - Anti-aging - Fat oxidation - Longevity ## Frequently asked ### What's the difference between Astragalus (Huang Qi) and MOTS-c? Astragalus (Huang Qi) is a adaptogen that astragalus (astragalus membranaceus) operates through multiple pharmacologic mechanisms reflecting its complex phytochemistry. the major active fractions — astragalus…. MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. The two differ in mechanism, half-life (not reported vs ~4–6 hours), and typical dose range. ### Which has the longer half-life, Astragalus (Huang Qi) or MOTS-c? Astragalus (Huang Qi) has a half-life of not reported. MOTS-c has a half-life of ~4–6 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Can you stack Astragalus (Huang Qi) and MOTS-c? Stacking depends on mechanism overlap, safety profile, and goals. Astragalus (Huang Qi) and MOTS-c should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. Astragalus (Huang Qi) prices: https://www.bodyhackguide.co/compound/astragalus?tab=prices MOTS-c prices: https://www.bodyhackguide.co/compound/mots-c?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy Astragalus (Huang Qi) or MOTS-c Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons MOTS C vs SS-31: https://www.bodyhackguide.co/compare/mots-c-vs-ss-31 Methylene Blue vs MOTS C: https://www.bodyhackguide.co/compare/methylene-blue-vs-mots-c MOTS C vs NMN: https://www.bodyhackguide.co/compare/mots-c-vs-nmn **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). 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