--- title: "AOD-9604 vs Semaglutide: Side-by-Side Comparison (2026)" description: "Compare AOD-9604 vs Semaglutide side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "AOD-9604 vs Semaglutide" } ] }, { "@context": "https://schema.org", "@type": "WebPage", "name": "AOD-9604 vs Semaglutide: Side-by-Side Comparison (2026)", "description": "Compare AOD-9604 vs Semaglutide side by side. We earn a commission on some vendor links. 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Semaglutide is a metabolic & weight loss that glp-1 receptor agonism and camp signaling semaglutide binds to the glp-1 receptor (glp-1r), a class b g-protein coupled receptor expressed on pancreatic beta cells, hypothalamic…. The two differ in mechanism, half-life (~30–60 minutes vs ~7 days (168 hours), enabled by C18 fatty diacid albumin-binding modification), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, AOD-9604 or Semaglutide?", "acceptedAnswer": { "@type": "Answer", "text": "AOD-9604 has a half-life of ~30–60 minutes. Semaglutide has a half-life of ~7 days (168 hours), enabled by C18 fatty diacid albumin-binding modification. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, AOD-9604 or Semaglutide?", "acceptedAnswer": { "@type": "Answer", "text": "Lowest listed price on BodyHackGuide: AOD-9604 from $34.99, Semaglutide from $39.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers." } }, { "@type": "Question", "name": "Can you stack AOD-9604 and Semaglutide?", "acceptedAnswer": { "@type": "Answer", "text": "Stacking depends on mechanism overlap, safety profile, and goals. AOD-9604 and Semaglutide should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds." } } ] } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+, enter siteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fcompare%2Faod-9604-vs-semaglutide) Compare notes with other researchers. Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 3. [Compare](/compare) 5. AOD-9604 vs Semaglutide # AOD-9604 vs Semaglutide Side-by-side comparison of AOD-9604 and Semaglutide: mechanism, half-life, dose range, safety profile, and vendor pricing. AOD-9604 from $34.99 Semaglutide from $39.00 ## Price snapshot ### AOD-9604 Current low $59.99 as of Sep 5, 2026 7-day low — no 7d data yet 30-day low $59.99 30-day change — baseline building ### Semaglutide Current low $139.99 as of Sep 5, 2026 7-day low — no 7d data yet 30-day low $64.99 30-day change — baseline building ## AOD-9604 AOD-9604 (Anti-Obesity Drug 9604) is a synthetic 16-amino-acid peptide fragment of human growth hormone (hGH) corresponding to residues 177-191 of the hGH molecule plus a tyrosine addition at the N-terminus (sequence:… **Lowest listed price:** $34.99 across 5 listings [Full AOD-9604 profile](/compound/aod-9604) ## Semaglutide Featured Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) with a molecular weight of 4113.58 Da and CAS number 910463-68-2. It is a 31-amino-acid peptide analog of human GLP-1(7-37) with two key structural… **Lowest listed price:** $39.00 across 13 listings [Full Semaglutide profile](/compound/semaglutide) ## Side-by-side comparison Attribute AOD-9604 Semaglutide Category Metabolic & Weight Loss Metabolic & Weight Loss Research Stage Phase 2 (discontinued for obesity); research-use-only FDA Approved Mechanism of Action AOD-9604's claimed mechanism is lipolysis (fat breakdown) via a C-terminal hGH-fragment-specific pathway distinct from classical growth hormone receptor signaling, though the mechanistic details remain incompletely characterized and contested. The "Lipolytic… GLP-1 Receptor Agonism and cAMP Signaling Semaglutide binds to the GLP-1 receptor (GLP-1R), a class B G-protein coupled receptor expressed on pancreatic beta cells, hypothalamic neurons, gastric smooth muscle, cardiac myocytes, and other tissues. Upon binding,… Half-Life ~30–60 minutes ~7 days (168 hours), enabled by C18 fatty diacid albumin-binding modification Typical Dose Range 250–600 mcg per injection Diabetes (Ozempic): 250-1000 mcg weekly; Weight management (Wegovy): 2400 mcg weekly (after 16-week titration); Oral (Rybelsus): 3-14 mg daily Dosing Frequency Once daily, typically morning fasted Once weekly subcutaneous injection Administration Subcutaneous, Oral Subcutaneous (weekly), Oral (daily) Side Effects AOD-9604's side effect profile is largely benign based on available data, reflecting its failure to produce significant physiological effects - a compound that does little tends to cause few side effects. From the developer's human trials (sponsor-reported; no… Nausea (especially at initiation — dose-dependent), vomiting, diarrhea, constipation, abdominal pain, decreased appetite (therapeutic effect), headache, fatigue, dizziness. Rare: pancreatitis, gallbladder issues, thyroid C-cell tumors (rodent studies).… Molecular Weight 1817.1 Da 4113.6 Da Common Vial Sizes 2mg, 5mg 3mg, 5mg, 10mg ## Price History 4 data points - BM - VANDL Labs - Ion Peptide - Disguised Alpha ## Price History 4 data points - OF - VANDL Labs - Ion Peptide - Disguised Alpha ### AOD-9604: potential benefits - Claimed lipolysis / fat loss (demonstrated only in rodent studies; not shown in human trials) - Does not raise IGF-1 or activate the GH receptor (no growth or proliferative signaling) - Does not impair insulin sensitivity or glucose tolerance in studies to date - Benign short-term safety and tolerability profile - Cartilage-protective effect in an animal (rabbit) osteoarthritis model - preclinical only ### Semaglutide: potential benefits - Mean body weight reduction of 14.9% at 68 weeks in STEP 1 trial (PMID: 33567185) - Sustained weight loss of ~15% (-15.2%) maintained through 104 weeks in STEP 5 trial (PMID: 36216945) - 20% relative reduction in major adverse cardiovascular events (HR 0.80) in the SELECT trial (PMID: 37952131) - HbA1c reduction of 1.5-1.8% in type 2 diabetes (SUSTAIN program) - Reduction in systemic inflammation (lower hs-CRP) observed in SELECT - Available in both subcutaneous (weekly) and oral (daily) formulations - Improved cardiometabolic risk factors including blood pressure and lipid profile ## Frequently asked ### What's the difference between AOD-9604 and Semaglutide? AOD-9604 is a metabolic & weight loss that aod-9604's claimed mechanism is lipolysis (fat breakdown) via a c-terminal hgh-fragment-specific pathway distinct from classical growth hormone receptor signaling, though the…. Semaglutide is a metabolic & weight loss that glp-1 receptor agonism and camp signaling semaglutide binds to the glp-1 receptor (glp-1r), a class b g-protein coupled receptor expressed on pancreatic beta cells, hypothalamic…. The two differ in mechanism, half-life (~30–60 minutes vs ~7 days (168 hours), enabled by C18 fatty diacid albumin-binding modification), and typical dose range. ### Which has the longer half-life, AOD-9604 or Semaglutide? AOD-9604 has a half-life of ~30–60 minutes. Semaglutide has a half-life of ~7 days (168 hours), enabled by C18 fatty diacid albumin-binding modification. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, AOD-9604 or Semaglutide? Lowest listed price on BodyHackGuide: AOD-9604 from $34.99, Semaglutide from $39.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack AOD-9604 and Semaglutide? Stacking depends on mechanism overlap, safety profile, and goals. AOD-9604 and Semaglutide should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. [AOD-9604 prices](/compound/aod-9604?tab=prices) [Semaglutide prices](/compound/semaglutide?tab=prices) [Compare all compounds](/compare) ### Before you buy AOD-9604 or Semaglutide Check the vendor trust score. 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