--- title: "5-Amino-1MQ vs MOTS-c: Side-by-Side Comparison (2026)" url: https://www.bodyhackguide.co/compare/5-amino-1mq-vs-mots-c description: "Compare 5-Amino-1MQ vs MOTS-c side by side. We earn a commission on some vendor links. Mechanism, half-life, dose range, side effects and prices." lang: en --- Skip to content Compare notes on r/BodyHackGuide (https://reddit.com/r/bodyhackguide) Compare notes with other researchers. Join r/BodyHackGuide (https://reddit.com/r/bodyhackguide) # 5-Amino-1MQ vs MOTS-c Side-by-side comparison of 5-Amino-1MQ and MOTS-c: mechanism, half-life, dose range, safety profile, and vendor pricing. 5-Amino-1MQ from $29.99 MOTS-c from $44.99 ## Price snapshot ### 5-Amino-1MQ Current low $29.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ### MOTS-c Current low $44.99 current listings 7-day low — not enough history yet 30-day low — not enough history yet 30-day change — not enough history yet ## 5-Amino-1MQ 5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to… **Lowest listed price:** $29.99 across 14 listings Full 5-Amino-1MQ profile (https://www.bodyhackguide.co/compound/5-amino-1mq) ## MOTS-c MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It… **Lowest listed price:** $44.99 across 9 listings Full MOTS-c profile (https://www.bodyhackguide.co/compound/mots-c) ## Side-by-side comparison | Attribute | 5-Amino-1MQ | MOTS-c | | --- | --- | --- | | Category | Weight Loss | Longevity & Cellular Health | | Research Stage | Preclinical | Preclinical | | Mechanism of Action | 5-Amino-1MQ works by inhibiting nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to the nitrogen of nicotinamide (vitamin B3 amide), producing 1-methylnicotinamide (1-MNA) and… | A New Class of Signaling Molecule MOTS-c belongs to the mitochondrial-derived peptides (MDPs) - a class of small peptides encoded within mitochondrial DNA open reading frames that were historically thought to encode only ribosomal RNAs. The known MDPs include:… | | Half-Life | ~6–12 hours (oral) | ~4–6 hours | | Typical Dose Range | 50 mg - 150 mg daily (oral or injection) | 5,000–10,000 mcg (5–10 mg) per injection | | Dosing Frequency | Once daily oral | 2-3 times per week | | Administration | Oral | Subcutaneous, Intramuscular | | Side Effects | The side effect profile of 5-amino-1MQ in humans is not documented because there are no human clinical trials. Rodent studies report generally good tolerability at doses producing metabolic and muscle benefits, without obvious signs of hepatotoxicity,… | Reported Effects (limited human data) - Injection site reactions — Mild erythema, transient itching at SC injection site. Site rotation minimizes. Probably the single most reported issue. - Transient fatigue — Some users report mild fatigue in the first week… | | Molecular Weight | 159.21 g/mol | 2174 Da | | Common Vial Sizes | 50mg capsules, 100mg capsules | 5mg, 10mg | ## Price History 5 data points - OF - BM - Half Nattys - Ion Peptide - Disguised Alpha - RC - LB ## Price History 5 data points - OF - BM - Half Nattys - Ion Peptide - Disguised Alpha - BHG Labs ### 5-Amino-1MQ: potential benefits - Enhanced fat metabolism and weight loss - Increased NAD+ levels in adipose tissue - Improved cellular energy production - Anti-aging properties via sirtuin activation ### MOTS-c: potential benefits - Insulin sensitivity - Exercise mimicry - Metabolic health - Anti-aging - Fat oxidation - Longevity ## Frequently asked ### What's the difference between 5-Amino-1MQ and MOTS-c? 5-Amino-1MQ is a weight loss that 5-amino-1mq works by inhibiting nicotinamide n-methyltransferase (nnmt), an enzyme that catalyzes the transfer of a methyl group from s-adenosyl-l-methionine (sam) to the nitrogen…. MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. The two differ in mechanism, half-life (~6–12 hours (oral) vs ~4–6 hours), and typical dose range. ### Which has the longer half-life, 5-Amino-1MQ or MOTS-c? 5-Amino-1MQ has a half-life of ~6–12 hours (oral). MOTS-c has a half-life of ~4–6 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics. ### Which is cheaper, 5-Amino-1MQ or MOTS-c? Lowest listed price on BodyHackGuide: 5-Amino-1MQ from $29.99, MOTS-c from $44.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers. ### Can you stack 5-Amino-1MQ and MOTS-c? Stacking depends on mechanism overlap, safety profile, and goals. 5-Amino-1MQ and MOTS-c should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds. ## See current vendor prices Listings from the vendors we track. Prices change often, so check the vendor before you buy. 5-Amino-1MQ prices: https://www.bodyhackguide.co/compound/5-amino-1mq?tab=prices MOTS-c prices: https://www.bodyhackguide.co/compound/mots-c?tab=prices Compare all compounds: https://www.bodyhackguide.co/compare ### Before you buy 5-Amino-1MQ or MOTS-c Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor. View Vendor Scorecard (https://www.bodyhackguide.co/vendors/scorecard) ## Related comparisons 5-Amino-1MQ vs Tirzepatide: https://www.bodyhackguide.co/compare/5-amino-1mq-vs-tirzepatide MOTS C vs SS-31: https://www.bodyhackguide.co/compare/mots-c-vs-ss-31 Methylene Blue vs MOTS C: https://www.bodyhackguide.co/compare/methylene-blue-vs-mots-c MOTS C vs NMN: https://www.bodyhackguide.co/compare/mots-c-vs-nmn **Research use only.** BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards (https://www.bodyhackguide.co/editorial-standards) and affiliate disclosure (https://www.bodyhackguide.co/affiliate-disclosure). 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MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. The two differ in mechanism, half-life (~6–12 hours (oral) vs ~4–6 hours), and typical dose range." } }, { "@type": "Question", "name": "Which has the longer half-life, 5-Amino-1MQ or MOTS-c?", "acceptedAnswer": { "@type": "Answer", "text": "5-Amino-1MQ has a half-life of ~6–12 hours (oral). MOTS-c has a half-life of ~4–6 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics." } }, { "@type": "Question", "name": "Which is cheaper, 5-Amino-1MQ or MOTS-c?", "acceptedAnswer": { "@type": "Answer", "text": "Lowest listed price on BodyHackGuide: 5-Amino-1MQ from $29.99, MOTS-c from $44.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. 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