--- title: "Best Peptides for Fat Loss — 2026 Buyer's Guide" description: "Top-ranked peptides for fat loss in 2026. Mechanism, dosing, and live vendor pricing for Retatrutide, Tesofensine, Semaglutide and more. Updated weekly." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co/" }, { "@type": "ListItem", "position": 2, "name": "Compare", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Best Peptides for Fat Loss" } ] }, { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bodyhackguide.co" }, { "@type": "ListItem", "position": 2, "name": "Best Of", "item": "https://www.bodyhackguide.co/compare" }, { "@type": "ListItem", "position": 3, "name": "Best Peptides for Fat Loss", "item": "https://www.bodyhackguide.co/best/peptides-for-fat-loss" } ] }, { "@context": "https://schema.org", "@type": "ItemList", "name": "Best Peptides for Fat Loss", "itemListElement": [ { "@type": "ListItem", "position": 1, "item": { "@type": "Drug", "name": "Retatrutide", "url": "https://www.bodyhackguide.co/compound/retatrutide", "description": "Retatrutide (also coded **LY3437943**) is an **investigational once-weekly triple-agonist** at the **GLP-1, GIP, and glucagon receptors** — the third-generation incretin-based therapy developed by Eli" } }, { "@type": "ListItem", "position": 2, "item": { "@type": "Drug", "name": "Tesofensine", "url": "https://www.bodyhackguide.co/compound/tesofensine", "description": "Tesofensine (NS2330) is an orally-administered small-molecule triple monoamine reuptake inhibitor — it blocks the reuptake of noradrenaline, dopamine, and serotonin, placing it in the same broad pharm" } }, { "@type": "ListItem", "position": 3, "item": { "@type": "Drug", "name": "Semaglutide", "url": "https://www.bodyhackguide.co/compound/semaglutide", "description": "Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) with a molecular weight of 4113.58 Da and CAS number 910463-68-2. It is a 31-amino-acid peptide analog of human GLP-1(7-37) with tw" } }, { "@type": "ListItem", "position": 4, "item": { "@type": "Drug", "name": "Tirzepatide", "url": "https://www.bodyhackguide.co/compound/tirzepatide", "description": "Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist with a molecular weight of 4813.45 Da and CAS number 2023788-19-2. It is a" } }, { "@type": "ListItem", "position": 5, "item": { "@type": "Drug", "name": "Mazdutide", "url": "https://www.bodyhackguide.co/compound/mazdutide", "description": "Mazdutide (also known as IBI362, Lilly compound LY3305677) is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist originally discovered by Eli Lilly and exclusively licensed to Innove" } }, { "@type": "ListItem", "position": 6, "item": { "@type": "Drug", "name": "Orforglipron", "url": "https://www.bodyhackguide.co/compound/orforglipron", "description": "Orforglipron (also known as LY3502970) is Eli Lilly's investigational oral, non-peptide, small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist for the treatment of obesity and type 2 diabete" } }, { "@type": "ListItem", "position": 7, "item": { "@type": "Drug", "name": "Cagrilintide", "url": "https://www.bodyhackguide.co/compound/cagrilintide", "description": "Cagrilintide (also known as AM833, development code NN9838) is a long-acting amylin analog developed by Novo Nordisk as a next-generation weight-management therapy, designed to be co-administered with" } }, { "@type": "ListItem", "position": 8, "item": { "@type": "Drug", "name": "Exenatide", "url": "https://www.bodyhackguide.co/compound/exenatide", "description": "Exenatide (Byetta, Bydureon) is a synthetic exendin-4 GLP-1 receptor agonist, FDA-approved for type 2 diabetes, that lowers blood glucose and curbs appetite. Available as a twice-daily immediate-relea" } }, { "@type": "ListItem", "position": 9, "item": { "@type": "Drug", "name": "AOD-9604", "url": "https://www.bodyhackguide.co/compound/aod-9604", "description": "AOD-9604 (Anti-Obesity Drug 9604) is a synthetic 16-amino-acid peptide fragment of human growth hormone (hGH) corresponding to residues 177-191 of the hGH molecule plus a tyrosine addition at the N-te" } }, { "@type": "ListItem", "position": 10, "item": { "@type": "Drug", "name": "HGH Fragment 176-191", "url": "https://www.bodyhackguide.co/compound/hgh-frag-176-191", "description": "**HGH Fragment 176-191** (also written HGH Frag 176-191, hGH Fragment 176-191, and frequently appearing in clinical literature as **AOD-9604** — \"Anti-Obesity Drug 9604\") is a synthetic peptide corres" } }, { "@type": "ListItem", "position": 11, "item": { "@type": "Drug", "name": "Tesamorelin", "url": "https://www.bodyhackguide.co/compound/tesamorelin", "description": "Tesamorelin is a **stabilized synthetic analog of human growth hormone-releasing hormone (GHRH)** — specifically the full 44-amino-acid GHRH sequence with a single N-terminal trans-3-hexenoyl fatty-ac" } }, { "@type": "ListItem", "position": 12, "item": { "@type": "Drug", "name": "SLU-PP-332", "url": "https://www.bodyhackguide.co/compound/slu-pp-332", "description": "SLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a l" } }, { "@type": "ListItem", "position": 13, "item": { "@type": "Drug", "name": "5-Amino-1MQ", "url": "https://www.bodyhackguide.co/compound/5-amino-1mq", "description": "5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to" } }, { "@type": "ListItem", "position": 14, "item": { "@type": "Drug", "name": "MOTS-c", "url": "https://www.bodyhackguide.co/compound/mots-c", "description": "MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a **16-amino-acid mitochondrial-derived peptide** — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rat" } }, { "@type": "ListItem", "position": 15, "item": { "@type": "Drug", "name": "BAM15", "url": "https://www.bodyhackguide.co/compound/bam15", "description": "BAM15 is a small-molecule mitochondrial protonophore uncoupler that was first described in 2014 as a tool compound for dissipating proton motive force selectively across the inner mitochondrial membra" } }, { "@type": "ListItem", "position": 16, "item": { "@type": "Drug", "name": "L-Carnitine", "url": "https://www.bodyhackguide.co/compound/l-carnitine", "description": "L-Carnitine is a naturally occurring quaternary ammonium compound synthesized in the body from the amino acids lysine and methionine, with essential cofactor roles in fatty acid metabolism, energy pro" } }, { "@type": "ListItem", "position": 17, "item": { "@type": "Drug", "name": "Lipo-C", "url": "https://www.bodyhackguide.co/compound/lipo-c", "description": "Lipo-C (also sold as a MIC or \"lipotropic\" injection) is a compounded blend of methionine, inositol, and choline, usually with vitamin B12 and sometimes L-carnitine, marketed by medspas and weight-los" } }, { "@type": "ListItem", "position": 18, "item": { "@type": "Drug", "name": "Berberine", "url": "https://www.bodyhackguide.co/compound/berberine", "description": "Berberine is an isoquinoline alkaloid — a naturally occurring plant secondary metabolite with a characteristic yellow color — extracted from the roots, rhizomes, stems, and bark of several plant gener" } }, { "@type": "ListItem", "position": 19, "item": { "@type": "Drug", "name": "Clenbuterol", "url": "https://www.bodyhackguide.co/compound/clenbuterol", "description": "Clenbuterol is a long-acting, selective beta-2 adrenergic receptor agonist originally developed in the late 1970s by Thomae GmbH (later Boehringer Ingelheim) as a bronchodilator for obstructive airway" } } ] }, { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What are the best peptides for fat loss?", "acceptedAnswer": { "@type": "Answer", "text": "The top-ranked peptides for fat loss based on research evidence and current vendor pricing are: 1) Retatrutide, 2) Tesofensine, 3) Semaglutide, 4) Tirzepatide, 5) Mazdutide. Each is profiled below with mechanism, dosing, and the cheapest current source." } }, { "@type": "Question", "name": "Which peptide works fastest for fat loss?", "acceptedAnswer": { "@type": "Answer", "text": "Onset varies by mechanism. Direct-acting compounds (e.g., metabolic agonists for fat loss, healing peptides for tissue repair) typically show effects within 2-4 weeks of consistent dosing. Adaptogenic and longevity compounds operate on slower 8-12 week timelines. Each compound profile has its own onset notes — see the linked research pages for specifics." } }, { "@type": "Question", "name": "Where to buy peptides for fat loss?", "acceptedAnswer": { "@type": "Answer", "text": "BodyHackGuide tracks live vendor pricing across every compound on this page. Each row links to the buyer-intent /buy/ page where vendors are ranked cheapest-first by price per mg, with active coupon codes surfaced. Trust Score rubric (0-100) filters out low-quality vendors before they're surfaced anywhere." } }, { "@type": "Question", "name": "Are these peptides legal to buy?", "acceptedAnswer": { "@type": "Answer", "text": "All compounds linked here are sold by vendors for research-use-only — no prescription required for research purchases. None of the vendors on BodyHackGuide sell research compounds for human consumption. BodyHackGuide editorial doesn't promote off-label use; we provide research data so qualified researchers can make informed sourcing decisions." } } ] } ] --- [Skip to content](#main-content) ## Research Use Only This site is an **educational resource** for research compounds. We do **not endorse** human consumption of any compound. BodyHackGuide and **BHG Labs share common ownership**; we rank every vendor on the same public methodology, and we earn a commission on purchases through our links. By entering, you confirm you are **21 years of age or older** and agree to our [Terms](/terms) & [Privacy Policy](/privacy). I'm 21+ — Enter SiteLeave site [![BodyHackGuide](/assets/bodyhackguide-logo-DOzZNUyh.webp)BodyHackGuide ](/) [Compare](/compare)[Wiki](/wiki)[Vendors](/vendors)[Deals](/deals)[Stacks](/stack-builder)[Nootropics](/nootropics)[Tools](/tools) Learn Community Search ⌘K [Sign In](/auth?returnTo=%2Fbest%2Fpeptides-for-fat-loss) 100K+ researchers trust BodyHackGuide — Join [r/BodyHackGuide](https://reddit.com/r/bodyhackguide) 1. [Home](/) 3. [Compare](/compare) 5. Best Peptides for Fat Loss 🔥 2026 Buyer's Guide # Best Peptides for Fat Loss — 2026 Top-ranked peptides for fat loss based on research evidence and current vendor availability. Each compound below links to its full research profile, live vendor pricing, and active coupon codes. Compounds researched for metabolic enhancement and body composition. ## Top 19 peptides for fat loss 1 ### Retatrutide Metabolic & Weight Loss Top pick Retatrutide (also coded \*\*LY3437943\*\*) is an \*\*investigational once-weekly triple-agonist\*\* at the \*\*GLP-1, GIP, and glucagon receptors\*\* — the third-generation incretin-based therapy developed by Eli Lilly. Where \[Semaglutide\](/compound/semaglutide) activates GLP-1 alone and \[Ti… Cheapest: **$79.99** at **VANDL Labs** · $16.00/mg · 11 active listings [Where to buy](/buy/retatrutide) [Research profile](/compound/retatrutide)[Coupon codes](/coupons/retatrutide) 2 ### Tesofensine Weight Loss Tesofensine (NS2330) is an orally-administered small-molecule triple monoamine reuptake inhibitor — it blocks the reuptake of noradrenaline, dopamine, and serotonin, placing it in the same broad pharmacologic class as sibutramine (withdrawn 2010 for cardiovascular risk) but with … Cheapest: **$79.99** at **ResearchChemHQ** · $2.67/mg · 3 active listings [Where to buy](/buy/tesofensine) [Research profile](/compound/tesofensine)[Coupon codes](/coupons/tesofensine) 3 ### Semaglutide Metabolic & Weight Loss Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) with a molecular weight of 4113.58 Da and CAS number 910463-68-2. It is a 31-amino-acid peptide analog of human GLP-1(7-37) with two key structural modifications: an alpha-aminoisobutyric acid (Aib) substitution… Cheapest: **$39.00** at **Ion Peptide** · $7.80/mg · 12 active listings [Where to buy](/buy/semaglutide) [Research profile](/compound/semaglutide)[Coupon codes](/coupons/semaglutide) 4 ### Tirzepatide Metabolic & Weight Loss Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist with a molecular weight of 4813.45 Da and CAS number 2023788-19-2. It is a 39-amino-acid synthetic peptide based on the native GIP sequence with modificat… Cheapest: **$49.00** at **Ion Peptide** · $4.90/mg · 14 active listings [Where to buy](/buy/tirzepatide) [Research profile](/compound/tirzepatide)[Coupon codes](/coupons/tirzepatide) 5 ### Mazdutide Weight Loss Mazdutide (also known as IBI362, Lilly compound LY3305677) is a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist originally discovered by Eli Lilly and exclusively licensed to Innovent Biologics in 2019 for development and commercialization in Mainland China, Ho… Cheapest: **$79.99** at **Disguised Alpha** · $16.00/mg · 1 active listing [Where to buy](/buy/mazdutide) [Research profile](/compound/mazdutide)[Coupon codes](/coupons/mazdutide) 6 ### Orforglipron Weight Loss Orforglipron (also known as LY3502970) is Eli Lilly's investigational oral, non-peptide, small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist for the treatment of obesity and type 2 diabetes. Unlike virtually every other GLP-1 receptor agonist on the market — \[Semaglut… Cheapest: **$149.99** at **Disguised Alpha** · 2 active listings [Where to buy](/buy/orforglipron) [Research profile](/compound/orforglipron)[Coupon codes](/coupons/orforglipron) 7 ### Cagrilintide Metabolic & Weight Loss Cagrilintide (also known as AM833, development code NN9838) is a long-acting amylin analog developed by Novo Nordisk as a next-generation weight-management therapy, designed to be co-administered with the GLP-1 receptor agonist semaglutide in a fixed-ratio combination known as Ca… Cheapest: **$49.99** at **ResearchChemHQ** · $10.00/mg · 4 active listings [Where to buy](/buy/cagrilintide) [Research profile](/compound/cagrilintide)[Coupon codes](/coupons/cagrilintide) 8 ### Exenatide Weight Loss Exenatide (Byetta, Bydureon) is a synthetic exendin-4 GLP-1 receptor agonist, FDA-approved for type 2 diabetes, that lowers blood glucose and curbs appetite. Available as a twice-daily immediate-release and a once-weekly extended-release injection. [Where to buy](/buy/exenatide) [Research profile](/compound/exenatide)[Coupon codes](/coupons/exenatide) 9 ### AOD-9604 Metabolic & Weight Loss AOD-9604 (Anti-Obesity Drug 9604) is a synthetic 16-amino-acid peptide fragment of human growth hormone (hGH) corresponding to residues 177-191 of the hGH molecule plus a tyrosine addition at the N-terminus (sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Ph… Cheapest: **$34.99** at **BioMyst Labs** · $7.00/mg · 4 active listings [Where to buy](/buy/aod-9604) [Research profile](/compound/aod-9604)[Coupon codes](/coupons/aod-9604) 10 ### HGH Fragment 176-191 Metabolic & Weight Loss \*\*HGH Fragment 176-191\*\* (also written HGH Frag 176-191, hGH Fragment 176-191, and frequently appearing in clinical literature as \*\*AOD-9604\*\* — "Anti-Obesity Drug 9604") is a synthetic peptide corresponding to the C-terminal 15-amino-acid region of the 191-amino-acid human growt… Cheapest: **$34.99** at **VANDL Labs** · $7.00/mg · 2 active listings [Where to buy](/buy/hgh-frag-176-191) [Research profile](/compound/hgh-frag-176-191)[Coupon codes](/coupons/hgh-frag-176-191) 11 ### Tesamorelin Growth Hormone / IGF-1 Axis Tesamorelin is a \*\*stabilized synthetic analog of human growth hormone-releasing hormone (GHRH)\*\* — specifically the full 44-amino-acid GHRH sequence with a single N-terminal trans-3-hexenoyl fatty-acid modification. That modification protects the peptide from rapid dipeptidyl pe… Cheapest: **$44.99** at **VANDL Labs** · $22.50/mg · 7 active listings [Where to buy](/buy/tesamorelin) [Research profile](/compound/tesamorelin)[Coupon codes](/coupons/tesamorelin) 12 ### SLU-PP-332 Performance SLU-PP-332 is the first-generation synthetic pan-agonist of the estrogen-related receptors (ERRα, ERRβ, ERRγ) developed by the laboratory of Thomas Burris at Saint Louis University and reported in a landmark 2023 publication that established ERR pan-agonism as a pharmacologically… Cheapest: **$69.99** at **VANDL Labs** · $1.40/mg · 7 active listings [Where to buy](/buy/slu-pp-332) [Research profile](/compound/slu-pp-332)[Coupon codes](/coupons/slu-pp-332) 13 ### 5-Amino-1MQ Weight Loss 5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine… Cheapest: **$29.99** at **BioMyst Labs** · $6.00/mg · 11 active listings [Where to buy](/buy/5-amino-1mq) [Research profile](/compound/5-amino-1mq)[Coupon codes](/coupons/5-amino-1mq) 14 ### MOTS-c Longevity & Cellular Health MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a \*\*16-amino-acid mitochondrial-derived peptide\*\* — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It was first characterized and named by \[Lee et al. in 201… Cheapest: **$44.99** at **BioMyst Labs** · $4.50/mg · 7 active listings [Where to buy](/buy/mots-c) [Research profile](/compound/mots-c)[Coupon codes](/coupons/mots-c) 15 ### BAM15 Weight Loss BAM15 is a small-molecule mitochondrial protonophore uncoupler that was first described in 2014 as a tool compound for dissipating proton motive force selectively across the inner mitochondrial membrane without collapsing the plasma membrane electrochemical gradient (\[Kenwood et … Cheapest: **$84.99** at **Disguised Alpha** · 1 active listing [Where to buy](/buy/bam15) [Research profile](/compound/bam15)[Coupon codes](/coupons/bam15) 16 ### L-Carnitine Weight Loss L-Carnitine is a naturally occurring quaternary ammonium compound synthesized in the body from the amino acids lysine and methionine, with essential cofactor roles in fatty acid metabolism, energy production, and cellular health. Chemically classified as a conditionally essential… Cheapest: **$34.99** at **VANDL Labs** · $0.00/mg · 5 active listings [Where to buy](/buy/l-carnitine) [Research profile](/compound/l-carnitine)[Coupon codes](/coupons/l-carnitine) 17 ### Lipo-C Weight Loss Lipo-C (also sold as a MIC or "lipotropic" injection) is a compounded blend of methionine, inositol, and choline, usually with vitamin B12 and sometimes L-carnitine, marketed by medspas and weight-loss clinics to support fat metabolism and energy. The individual nutrients have re… Cheapest: **$42.99** at **ResearchChemHQ** · $4.30/mg · 3 active listings [Where to buy](/buy/lipo-c) [Research profile](/compound/lipo-c)[Coupon codes](/coupons/lipo-c) 18 ### Berberine Metabolic Berberine is an isoquinoline alkaloid — a naturally occurring plant secondary metabolite with a characteristic yellow color — extracted from the roots, rhizomes, stems, and bark of several plant genera including Berberis (barberry, Oregon grape), Coptis (goldthread), Hydrastis (g… [Where to buy](/buy/berberine) [Research profile](/compound/berberine)[Coupon codes](/coupons/berberine) 19 ### Clenbuterol Controlled Substances Clenbuterol is a long-acting, selective beta-2 adrenergic receptor agonist originally developed in the late 1970s by Thomae GmbH (later Boehringer Ingelheim) as a bronchodilator for obstructive airway disease. Structurally it is a sympathomimetic amine — 4-amino-alpha-\[(tert-buty… Cheapest: **$64.99** at **Disguised Alpha** · 2 active listings [Where to buy](/buy/clenbuterol) [Research profile](/compound/clenbuterol)[Coupon codes](/coupons/clenbuterol) [ Fat Loss hub Browse every compound tagged for fat loss, including stack ideas. ](/goal/fat-loss)[ Compare prices Real-time vendor pricing across every tracked research compound. ](/compare)[ Trust Score rubric The 0-100 vendor scoring system used to filter every link on this page. ](/vendors/methodology) ## Best peptides for fat loss — FAQ ### What are the best peptides for fat loss? The top-ranked peptides for fat loss based on research evidence and current vendor pricing are: 1) Retatrutide, 2) Tesofensine, 3) Semaglutide, 4) Tirzepatide, 5) Mazdutide. Each is profiled below with mechanism, dosing, and the cheapest current source. ### Which peptide works fastest for fat loss? Onset varies by mechanism. Direct-acting compounds (e.g., metabolic agonists for fat loss, healing peptides for tissue repair) typically show effects within 2-4 weeks of consistent dosing. Adaptogenic and longevity compounds operate on slower 8-12 week timelines. Each compound profile has its own onset notes — see the linked research pages for specifics. ### Where to buy peptides for fat loss? BodyHackGuide tracks live vendor pricing across every compound on this page. Each row links to the buyer-intent /buy/ page where vendors are ranked cheapest-first by price per mg, with active coupon codes surfaced. Trust Score rubric (0-100) filters out low-quality vendors before they're surfaced anywhere. ### Are these peptides legal to buy? All compounds linked here are sold by vendors for research-use-only — no prescription required for research purchases. None of the vendors on BodyHackGuide sell research compounds for human consumption. 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